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Enoyl-acyl Carrier Protein Reductase
Enoyl-acyl carrier protein reductase (or ENR) (), is a key enzyme of the type II fatty acid synthesis (FAS) system. ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes. : At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria ''Streptococcus pneumoniae''. See also * Enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific) * Enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific) * Cis-2-enoyl-CoA reductase (NADPH) In enzymology, a cis-2-enoyl-CoA reductase (NADPH) () is an enzyme that catalyzes the chemical reaction :acyl-CoA + NADP+ \rightleftharpoons ci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Acid Metabolism
Fatty acid metabolism consists of various metabolic processes involving or closely related to fatty acids, a family of molecules classified within the lipid macronutrient category. These processes can mainly be divided into (1) catabolic processes that generate energy and (2) anabolic processes where they serve as building blocks for other compounds. In catabolism, fatty acids are metabolized to produce energy, mainly in the form of adenosine triphosphate (ATP). When compared to other macronutrient classes (carbohydrates and protein), fatty acids yield the most ATP on an energy per gram basis, when they are completely oxidized to CO2 and water by beta oxidation and the citric acid cycle. Fatty acids (mainly in the form of triglycerides) are therefore the foremost storage form of fuel in most animals, and to a lesser extent in plants. In anabolism, intact fatty acids are important precursors to triglycerides, phospholipids, second messengers, hormones and ketone bodies. For exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triclosan
Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including toothpaste, soaps, detergents, toys, and surgical cleaning treatments. It is similar in its uses and mechanism of action to triclocarban. Its efficacy as an antimicrobial agent, the risk of antimicrobial resistance, and its possible role in disrupted hormonal development remains controversial. Additional research seeks to understand its potential effects on organisms and environmental health. Triclosan was developed in 1966. A 2006 study recommended showering with 2% triclosan as a regimen in surgical units to rid patients' skin of methicillin-resistant ''Staphylococcus aureus'' (MRSA). While finding benefit for consumers and no proven risk to human health, but assumed risk of antibiotic resistance, in December 2017, the FDA announced that "consumer antiseptic washes" containing triclosan or 23 other ingredients marketed as antimicrobials were pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triclocarban
Triclocarban (sometimes abbreviated as TCC) is an antibacterial chemical once common in, but now phased out of, personal care products like soaps and lotions. It was originally developed for the medical field. Although the mode of action is unknown, TCC can be effective in fighting infections by targeting the growth of bacteria such as '' Staphylococcus aureus''. Additional research seeks to understand its potential for causing antibacterial resistance and its effects on organismal and environmental health. Usage Triclocarban has been used as an antimicrobial and antifungal compound since the 1960s. It was commonly found in personal care products as an antimicrobial in soaps, lotions, deodorants, toothpaste, and plastic. about 80% of all antimicrobial bar soap sold in the United States contained triclocarban. In 2011 United States consumers were spending nearly 1 billion dollars annually on products containing triclocarban and triclosan. In December 2013, the Food and Drug Adm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteriostatic
A bacteriostatic agent or bacteriostat, abbreviated Bstatic, is a biological or chemical agent that stops bacteria from reproducing, while not necessarily killing them otherwise. Depending on their application, bacteriostatic antibiotics, disinfectants, antiseptics and preservatives can be distinguished. When bacteriostatic antimicrobials are used, the duration of therapy must be sufficient to allow host defense mechanisms to eradicate the bacteria. Upon removal of the bacteriostat, the bacteria usually start to grow rapidly. This is in contrast to bactericides, which kill bacteria. Bacteriostats are often used in plastics to prevent growth of bacteria on surfaces. Bacteriostats commonly used in laboratory work include sodium azide (which is acutely toxic) and thiomersal. __TOC__ Bacteriostatic antibiotics Bacteriostatic antibiotics limit the growth of bacteria by interfering with bacterial protein production, DNA replication, or other aspects of bacterial cellular metabolism. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atromentin
Atromentin is a natural chemical compound found in Agaricomycetes fungi in the orders Agaricales and Thelephorales. It can also be prepared by laboratory synthesis. Chemically, it is a polyphenol and a benzoquinone. Occurrences Atromentin has been found in cultures of ''Clitocybe subilludens'' and in extracts of ''Hydnellum peckii''. The first enzymes in its biosynthesis have been characterized in ''Tapinella panuoides''. One of those is called atromentin synthetase. Biological activities A number of potential biological activities of atromentin have been studied ''in vitro''. Atromentin possesses ''in vitro'' antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase (essential for the biosynthesis of fatty acids) in the bacteria ''Streptococcus pneumoniae''. Atromentin has been shown to be a smooth muscle stimulant. It also induces apoptosis in isolated human leukemia U937 cells. It is also an anticoagulant. Genetic and enzymatic basis of atro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Streptococcus Pneumoniae
''Streptococcus pneumoniae'', or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic (under aerobic conditions) or beta-hemolytic (under anaerobic conditions), aerotolerant anaerobic member of the genus Streptococcus. They are usually found in pairs (diplococci) and do not form spores and are non motile. As a significant human pathogenic bacterium ''S. pneumoniae'' was recognized as a major cause of pneumonia in the late 19th century, and is the subject of many humoral immunity studies. ''Streptococcus pneumoniae'' resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal cavity. However, in susceptible individuals with weaker immune systems, such as the elderly and young children, the bacterium may become pathogenic and spread to other locations to cause disease. It spreads by direct person-to-person contact via respiratory droplets and by auto inoculation in persons carrying the bacteria in their upper r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enoyl-(acyl-carrier-protein) Reductase (NADPH, A-specific)
In enzymology, an enoyl- cyl-carrier-proteinreductase (NADPH, A-specific) () is an enzyme that catalyzes the chemical reaction :acyl- cyl-carrier-protein+ NADP+ \rightleftharpoons trans-2,3-dehydroacyl- cyl-carrier-protein+ NADPH + H+ Thus, the two substrates of this enzyme are cyl-carrier-protein.html"_;"title="acyl-[acyl-carrier-protein">acyl-[acyl-carrier-proteinand_nicotinamide_adenine_dinucleotide_phosphate.html" ;"title="cyl-carrier-protein.html" ;"title="cyl-carrier-protein.html" ;"title="acyl-acyl-[acyl-carrier-protein">cyl-carrier-protein.html"_;"title="acyl-[acyl-carrier-protein">acyl-[acyl-carrier-proteinand_nicotinamide_adenine_dinucleotide_phosphate">NADP+,_whereas_its_3_product_(chemistry).html" "title="cyl-carrier-protein">acyl-[acyl-carrier-protein">cyl-carrier-protein.html" ;"title="acyl-[acyl-carrier-protein">acyl-[acyl-carrier-proteinand nicotinamide adenine dinucleotide phosphate">NADP+, whereas its 3 product (chemistry)">products are trans-2,3-dehydroacyl- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enoyl-(acyl-carrier-protein) Reductase (NADPH, B-specific)
In enzymology, an enoyl- cyl-carrier-proteinreductase (NADPH, B-specific) () is an enzyme that catalyzes the chemical reaction :acyl- cyl-carrier-protein+ NADP+ \rightleftharpoons trans-2,3-dehydroacyl- cyl-carrier-protein+ NADPH + H+ Thus, the two substrates of this enzyme are cyl-carrier-protein.html"_;"title="acyl-[acyl-carrier-protein">acyl-[acyl-carrier-proteinand_nicotinamide_adenine_dinucleotide_phosphate.html" ;"title="cyl-carrier-protein.html" ;"title="cyl-carrier-protein.html" ;"title="acyl-acyl-[acyl-carrier-protein">cyl-carrier-protein.html"_;"title="acyl-[acyl-carrier-protein">acyl-[acyl-carrier-proteinand_nicotinamide_adenine_dinucleotide_phosphate">NADP+,_whereas_its_3_product_(chemistry).html" "title="cyl-carrier-protein">acyl-[acyl-carrier-protein">cyl-carrier-protein.html" ;"title="acyl-[acyl-carrier-protein">acyl-[acyl-carrier-proteinand nicotinamide adenine dinucleotide phosphate">NADP+, whereas its 3 product (chemistry)">products are trans-2,3-dehydroacyl- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cis-2-enoyl-CoA Reductase (NADPH)
In enzymology, a cis-2-enoyl-CoA reductase (NADPH) () is an enzyme that catalyzes the chemical reaction :acyl-CoA + NADP+ \rightleftharpoons cis-2,3-dehydroacyl-CoA + NADPH + H+ Thus, the two substrates of this enzyme are acyl-CoA and NADP+, whereas its 3 products are cis-2,3-dehydroacyl-CoA, NADPH, and H+. Nomenclature This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ... of this enzyme class is acyl-CoA:NADP+ cis-2-oxidoreductase. Other names in common use include NADPH-dependent cis-enoyl-CoA reductase, reductase, cis-2-enoyl coenzyme A, cis-2-enoyl-coenzyme A reductase, and cis-2-enoyl-CoA reductase (NADPH). R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
