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Elisa Izaurralde
Elisa Izaurralde (20 September 1959 in Montevideo, Uruguay – 30 April 2018 in Tübingen, Germany) was an Uruguayan biochemist and molecular biologist. She served as Director and Scientific Member of the Department of Biochemistry at the Max Planck Institute for Developmental Biology in Tübingen from 2005 until her death in 2018. In 2008, she was awarded the Gottfried Wilhelm Leibniz Prize, shared with Elena Conti, for "fundamental new insights into intracellular RNA transport and RNA metabolism". Together with Conti, she helped characterize proteins important for exporting mRNA out of the nucleus and later in her career she helped elucidate mechanisms of mRNA silencing, translational repression, and mRNA decay. Early life and education Elisa Izaurralde was born in Montevideo, Uruguay on 20 September 1959. At the age of 17 she left Uruguay to pursue an education at Geneva University in Switzerland. After undergraduate training in biochemistry, she went on to receive a PhD in mol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Montevideo
Montevideo () is the Capital city, capital and List of cities in Uruguay, largest city of Uruguay. According to the 2011 census, the city proper has a population of 1,319,108 (about one-third of the country's total population) in an area of . Montevideo is situated on the southern coast of the country, on the northeastern bank of the Río de la Plata. The city was established in 1724 by a Spanish soldier, Bruno Mauricio de Zabala, as a strategic move amidst the Spanish people, Spanish-Portuguese people, Portuguese dispute over the La Plata Basin, platine region. It was also under brief British invasions of the Río de la Plata, British rule in 1807, but eventually the city was retaken by Spanish criollos who defeated the British invasions of the River Plate. Montevideo is the seat of the administrative headquarters of Mercosur and ALADI, Latin America's leading trade blocs, a position that entailed comparisons to the role of Brussels in Europe. The 2019 Mercer's report on qual ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iain Mattaj
Iain William Mattaj (born 5 October 1952 in St Andrews, Scotland) Fellow of the Royal Society, FRS FRSE is a British scientist and Honorary title (academic), Honorary Professor at Heidelberg University in Germany. From 2005 to 2018 he was Director General of the European Molecular Biology Laboratory (EMBL). He stepped down from the position at the end of 2018 following his appointment to Human Technopole. In January 2019 he took office as the first Director of Human Technopole, the new Italian institute for life sciences in Milan, Italy. Education Prof. Mattaj has a degree in Biochemistry from the University of Edinburgh (BSc) and he obtained a PhD from the University of Leeds in 1980 for research on cloned Glutamate dehydrogenase (GDH) genes supervised by John Wooton. He carried out his postdoctoral research at the Friedrich Miescher Institute (CH) and then at the Biocentre, University of Basel. There he worked in the laboratory of Eddy De Robertis and established the research ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TNRC6A
Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the ''TNRC6A'' gene. This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute The Argonaute protein family, first discovered for its evolutionarily conserved stem cell function, plays a central role in RNA silencing processes as essential components of the RNA-induced silencing complex (RISC). RISC is responsible for the g ... proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. References Further reading * * * * * * * * * * * * * * * * * * * {{gene-16-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA-induced Silencing Complex
The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which functions in gene silencing via a variety of pathways at the transcriptional and translational levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as a key tool in gene regulation. The single strand of RNA acts as a template for RISC to recognize complementary messenger RNA (mRNA) transcript. Once found, one of the proteins in RISC, Argonaute, activates and cleaves the mRNA. This process is called RNA interference (RNAi) and it is found in many eukaryotes; it is a key process in defense against viral infections, as it is triggered by the presence of double-stranded RNA (dsRNA). Discovery The biochemical identification of RISC was conducted by Gregory Hannon and his colleagues at the Cold Spring Harbor Laboratory. This was only a couple of years after the discovery of RNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MicroRNA
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in mRNA molecules, then gene silence said mRNA molecules by one or more of the following processes: (1) cleavage of mRNA strand into two pieces, (2) destabilization of mRNA by shortening its poly(A) tail, or (3) translation of mRNA into proteins. This last method of gene silencing is the least efficient of the three, and requires the aid of ribosomes. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1900 miRNAs, although more recent analysis suggests that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Translation (biology)
In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or endoplasmic reticulum synthesize proteins after the process of transcription (biology), transcription of DNA to RNA in the cell's nucleus (cell), nucleus. The entire process is called gene expression. In translation, mRNA, messenger RNA (mRNA) is decoded in a ribosome, outside the nucleus, to produce a specific amino acid chain, or polypeptide. The polypeptide later protein folding, folds into an Activation energy, active protein and performs its functions in the Cell (biology), cell. The ribosome facilitates decoding by inducing the binding of Base pair, complementary tRNA anticodon sequences to mRNA codons. The tRNAs carry specific amino acids that are chained together into a polypeptide as the mRNA passes through and is "read" by the ribosome. Translation proceeds in three phases: # Initiation: The ribosome assembles around the target mRNA. The first tRNA is attached a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytoplasm
In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. The main components of the cytoplasm are cytosol (a gel-like substance), the organelles (the cell's internal sub-structures), and various cytoplasmic inclusions. The cytoplasm is about 80% water and is usually colorless. The submicroscopic ground cell substance or cytoplasmic matrix which remains after exclusion of the cell organelles and particles is groundplasm. It is the hyaloplasm of light microscopy, a highly complex, polyphasic system in which all resolvable cytoplasmic elements are suspended, including the larger organelles such as the ribosomes, mitochondria, the plant plastids, lipid droplets, and vacuoles. Most cellular activities take place within the cytoplasm, such as many metabolic pathways including glycolysis, and proces ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Messenger RNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the process of transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and, utilising amino acids carried by transfer RNA (tRNA), the ribosome creates the protein. This process is known as translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genetic information in a biological system. As in DNA, genetic inf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription (biology)
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA ( Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA. Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Transcription proceeds in the following general steps: # RNA polymerase, together with one or more general transcription factors, binds to promoter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lori Passmore
Lori Anne Passmore is a Canadian/British cryo electron microscopist and structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge. She is known for her work on multiprotein complexes involved in gene expression and development of new supports for cryo-EM. Education Lori Passmore graduated from the University of British Columbia, Canada in 1999. She obtained a PhD in 2003 from University of London for research supervised by David Barford at the Institute of Cancer Research. She performed ''in vitro'' biochemical characterisation of the activity of the anaphase-promoting complex (APC) and used cryo-EM to study the APC structure. Career and research Passmore worked as a postdoctoral researcher at the MRC-LMB. She worked with Venki Ramakrishnan and Richard Henderson, using cryo-EM to determine the structure of the eukaryotic ribosome bound to initiation factors. Passmore became a group leade ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA Society
The RNA Society is a non-profit, international scientific society that serves to facilitate the dissemination of scientific results and concepts in ribonucleic acid (RNA) research. The society was founded in 1993 and currently consists of over 1800 members. History The RNA Society was founded in 1993. By Olke Uhlenbeck's account, the society spawned from a group of scientists studying RNA processing which first grew from a meeting at Brookhaven National Laboratory in 1974 and held annual meetings at Cold Spring Harbor starting in 1982. The society was formed for tax reasons following a surplus of money from a 1992 RNA processing meeting in Boulder, Colorado. The first president was Tom Cech, Joan Steitz was the first vice-president and president-"elect", Chris Greer was the first CEO, and Uhlenbeck was the first secretary/treasurer. In 2005, after more than 20 years of the society's existence, John Abelson deemed it a big success through its unique journal and annual meeting s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLOS Biology
''PLOS Biology'' is a monthly peer-reviewed scientific journal covering all aspects of biology. Publication began on October 13, 2003. It is the first journal published by the Public Library of Science. The editor-in-chief is Nonia Pariente. In addition to research articles, the journal publishes magazine content aimed to be accessible to a broad audience. Article types in this section are essays, "unsolved mysteries", editorials, and synopses. Abstracting and indexing The journal is abstracted and indexed in: *Biological Abstracts *BIOSIS Previews *''Current Contents''/Agriculture, Biology & Environmental Sciences *''Current Contents''/Life Sciences *Chemical Abstracts Service * Embase *''Index Medicus''/MEDLINE/PubMed *Science Citation Index *Scopus *''The Zoological Record'' According to ''Journal Citation Reports'', the journal had a 2019 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clariv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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