Electrical Stimulation Of The Brain
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Electrical Stimulation Of The Brain
Electrical brain stimulation (EBS), also referred to as focal brain stimulation (FBS), is a form of electrotherapy used as a technique in research and clinical neurobiology to stimulate a neuron or neural network in the brain through the direct or indirect excitation of its cell membrane by using an electric current. EBS is used for research or for therapeutic purposes. History Electrical brain stimulation was first used in the first half of the 19th century by pioneering researchers such as Luigi Rolando (1773–1831) and Pierre Flourens (1794–1867), to study the brain localization of function, following the discovery by Italian physician Luigi Galvani (1737–1798) that nerves and muscles were electrically excitable. The stimulation of the surface of the cerebral cortex by using brain stimulation was used to investigate the motor cortex in animals by researchers such as Eduard Hitzig (1838–1907), Gustav Fritsch (1838–1927), David Ferrier (1842–1928) and Friedrich G ...
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Nerve
A nerve is an enclosed, cable-like bundle of nerve fibers (called axons) in the peripheral nervous system. A nerve transmits electrical impulses. It is the basic unit of the peripheral nervous system. A nerve provides a common pathway for the electrochemical nerve impulses called action potentials that are transmitted along each of the axons to peripheral organs or, in the case of sensory nerves, from the periphery back to the central nervous system. Each axon, within the nerve, is an extension of an individual neuron, along with other supportive cells such as some Schwann cells that coat the axons in myelin. Within a nerve, each axon is surrounded by a layer of connective tissue called the endoneurium. The axons are bundled together into groups called fascicles, and each fascicle is wrapped in a layer of connective tissue called the perineurium. Finally, the entire nerve is wrapped in a layer of connective tissue called the epineurium. Nerve cells (often called neurons) are f ...
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Victor Horsley
Sir Victor Alexander Haden Horsley (14 April 1857 – 16 July 1916) was a British scientist and professor. He was born in Kensington, London. Educated at Cranbrook School, Kent, he studied medicine at University College London and in Berlin, Germany (1881) and, in the same year, started his career as a house surgeon and registrar at the University College Hospital. From 1884 to 1890, Horsley was Professor-Superintendent of the Brown Institute. In 1886, he was appointed as Assistant Professor of Surgery at the National Hospital for Paralysis and Epilepsy, and as a Professor of Pathology (1887–1896) and Professor of Clinical Surgery (1899–1902) at University College London. He was a supporter of women's suffrage and was an opponent of tobacco and alcohol. Personal life Victor Horsley was born in Kensington, London, the son of Rosamund Haden and John Callcott Horsley, R.A. His given names, Victor Alexander, were given to him by Queen Victoria. In 1883, he became engaged to ...
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Stereotactic Method
Stereotactic surgery is a minimally invasive form of surgical intervention that makes use of a three-dimensional coordinate system to locate small targets inside the body and to perform on them some action such as ablation, biopsy, lesion, injection, stimulation, implantation, radiosurgery (SRS), etc. In theory, any organ system inside the body can be subjected to stereotactic surgery. However, difficulties in setting up a reliable frame of reference (such as bone landmarks, which bear a constant spatial relation to soft tissues) mean that its applications have been, traditionally and until recently, limited to brain surgery. Besides the brain, biopsy and surgery of the breast are done routinely to locate, sample (biopsy), and remove tissue. Plain X-ray images (radiographic mammography), computed tomography, and magnetic resonance imaging can be used to guide the procedure. Another accepted form of "stereotactic" is "stereotaxic". The word roots are '' stereo-'', a prefix deriv ...
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Fedor Krause
Fedor Krause (10 March 1857 – in Friedland in Niederschlesien; 20 September 1937 in Bad Gastein) was a German neurosurgeon who was native of Friedland (Lower Silesia). Biography He originally studied music at the Conservatoire in Berlin, and later switched to medicine, earning his doctorate at Humboldt University in Berlin. In 1883 he became a medical assistant to Richard von Volkmann (1830-1889) at the surgical university clinic at Halle. Afterwards, he was a pathologist at the Senckenberg Institute in Frankfurt am Main (1890–92), a surgeon at the city hospital at Hamburg-Altona (1892-1900), and later head of the surgical department at Augusta Hospital in Berlin. In 1901 he became an associate professor at the University of Berlin. While in Berlin, he worked closely with neurologist Hermann Oppenheim (1858-1919) and he lived on island Schwanenwerder. During World War I he served as a surgical consultant, and following the war embarked on scientific journeys to La ...
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Robert Bartholow
Roberts Bartholow or Robert Bartholow (November 28, 1831 – May 10, 1904) was an American physician and a professor at several American medical colleges. He is best known for his experiments involving a 30-year-old patient named Mary Rafferty. Rafferty was admitted to Good Samaritan Hospital in Cincinnati, Ohio in 1874 with a 2-inch-diameter (51 mm) hole in her skull caused by a cancerous ulcer. Bartholow experimented with applying current to Rafferty's exposed dura using needle electrodes. His report detailed the first observations of how electrical stimulation of the brain affects motor functions of the body, but many ethical concerns were raised about the way in which he carried out his experiments. Rafferty went into a coma for three days and then died the day after coming out of the coma from a massive seizure. Education and career Roberts Bartholow was born in New Windsor, Maryland. He attended Calvert College in his hometown, and graduated in 1848 with a Bachelor ...
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Neurologist
Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal cord and the peripheral nerves. Neurological practice relies heavily on the field of neuroscience, the scientific study of the nervous system. A neurologist is a physician specializing in neurology and trained to investigate, diagnose and treat neurological disorders. Neurologists treat a myriad of neurologic conditions, including stroke, seizures, movement disorders such as Parkinson's disease, autoimmune neurologic disorders such as multiple sclerosis, headache disorders like migraine and dementias such as Alzheimer's disease. Neurologists may also be involved in clinical research, clinical trials, and basic or translational research. While neurology is a nonsurgical specialty, its corresponding surgical specialty is neurosurgery. Histor ...
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Neurosurgeon
Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty concerned with the surgical treatment of disorders which affect any portion of the nervous system including the brain, spinal cord and peripheral nervous system. Education and context In different countries, there are different requirements for an individual to legally practice neurosurgery, and there are varying methods through which they must be educated. In most countries, neurosurgeon training requires a minimum period of seven years after graduating from medical school. United States In the United States, a neurosurgeon must generally complete four years of undergraduate education, four years of medical school, and seven years of residency (PGY-1-7). Most, but not all, residency programs have some component of basic science or clinical research. Neurosurgeons may pursue additional training in the form of a fellowship after residency, or, in some cases, as a senior resid ...
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Friedrich Goltz
Friedrich Leopold Goltz (14 August 1834 – 5 May 1902) was a German physiologist and nephew of the writer Bogumil Goltz. Born in Posen (Poznań), Grand Duchy of Posen, he studied medicine at the University of Königsberg, and following two years of surgical training, served as a prosector of anatomy in Königsberg. In 1870 he succeeded A.W. Volkmann as professor of physiology at the University of Halle, followed by a professorship at the University of Straßburg (from 1872).Virtual Laboratory
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David Ferrier
Sir David Ferrier FRS (13 January 1843 – 19 March 1928) was a pioneering Scottish neurologist and psychologist. Ferrier conducted experiments on the brains of animals such as monkeys and in 1881 became the first scientist to be prosecuted under the Cruelty to Animals Act, 1876 which had been enacted following a major public debate over vivisection. Life Ferrier was born in Woodside near Aberdeen, and educated at Aberdeen Grammar School before studying for an MA at Aberdeen University (graduated 1863). As a medical student, he began to work as a scientific assistant to the influential free-thinking philosopher and psychologist Alexander Bain (1818–1903), one of the founders of associative psychology. Around 1860, psychology was finding its scientific foundation mainly in Germany, with the rigorous research of Hermann von Helmholtz (1821–1894), who had trained as a physicist, and of Wilhelm Wundt (1832–1920). They focused their work mainly in the area of sensory psych ...
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Gustav Fritsch
Gustav Theodor Fritsch (5 March 1838 – 12 June 1927) was a German anatomist, anthropologist, traveller and physiologist from Cottbus. Fritsch studied natural science and medicine in Berlin, Breslau and Heidelberg. In 1874 he became an associate professor of physiology at the University of Berlin, where he was later appointed head of the histological department at the physiological institute. He is known for his work with neuropsychiatrist Eduard Hitzig (1839–1907) involving the localization of the motor areas of the brain. In 1870, the two scientists probed the cerebral cortex of a dog to discover that electrical stimulation of different areas of the cerebrum caused involuntary muscular contractions of specific parts of the dog's body. Along with his medical studies, Fritsch was also known for his ethnographical research in southern Africa (1863–66), during which time he traveled from Cape Town through the Orange Free State, Basutoland, Natal and Bechuanaland. In 1 ...
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Eduard Hitzig
Eduard Hitzig (6 February 1838 – 20 August 1907) was a German neurologist and neuropsychiatrist of Jewish ancestryAndrew P. Wickens, ''A History of the Brain: From Stone Age Surgery to Modern Neuroscience'', Psychology Press (2014), p. 226 born in Berlin. He studied medicine at the Universities of Berlin and Würzburg under the instruction of famous men such as Emil Du Bois-Reymond (1818–1896), Rudolf Virchow (1821–1902), Moritz Heinrich Romberg (1795–1873), and Karl Friedrich Otto Westphal (1833–1890). He received his doctorate in 1862 and subsequently worked in Berlin and Würzburg. In 1875, he became director of the Burghölzli asylum, as well as professor of psychiatry at the University of Zurich. In 1885, Hitzig became a professor at the University of Halle where he remained until his retirement in 1903. Hitzig is remembered for his work concerning the interaction between electric current and the brain. In 1870, Hitzig, assisted by anatomist Gustav Fritsch (18 ...
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