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Edward Stone (natural Philosopher)
Edward Stone (1702–1768) was a Church of England cleric who discovered the active ingredient of aspirin. Life Edward Stone was born in Princes Risborough, Buckinghamshire, England, in 1702. His parents were Edward Stone, a gentleman farmer, and his first wife Elizabeth Reynolds. His mother having died, his father took a second wife, Elizabeth Grubb, in 1707; the Grubb family was to play a major role in Stone's life. Stone went to Wadham College, Oxford, in 1720, where in 1730 he became a Fellow. In 1728 or 1729 he was ordained deacon and priest, and served as curate at Charlton-on-Otmoor. From 1738 Stone held a living at Horsenden, Buckinghamshire, to which he was presented by John Grubb, brother to his stepmother. He married Elizabeth Grubb(e) at Mercers' Hall Chapel, Cheapside (a non-parochial church), London, on 7 July 1741: she was John Grubb's daughter. As was required at that period, Stone resigned as Fellow of Wadham on marrying. In 1745, Stone became chaplain to Sir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Church Of England
The Church of England (C of E) is the established Christian church in England and the mother church of the international Anglican Communion. It traces its history to the Christian church recorded as existing in the Roman province of Britain by the 3rd century and to the 6th-century Gregorian mission to Kent led by Augustine of Canterbury. The English church renounced papal authority in 1534 when Henry VIII failed to secure a papal annulment of his marriage to Catherine of Aragon. The English Reformation accelerated under Edward VI's regents, before a brief restoration of papal authority under Queen Mary I and King Philip. The Act of Supremacy 1558 renewed the breach, and the Elizabethan Settlement charted a course enabling the English church to describe itself as both Reformed and Catholic. In the earlier phase of the English Reformation there were both Roman Catholic martyrs and radical Protestant martyrs. The later phases saw the Penal Laws punish Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blue Plaque
A blue plaque is a permanent sign installed in a public place in the United Kingdom and elsewhere to commemorate a link between that location and a famous person, event, or former building on the site, serving as a historical marker. The term is used in the United Kingdom in two different senses. It may be used narrowly and specifically to refer to the "official" scheme administered by English Heritage, and currently restricted to sites within Greater London; or it may be used less formally to encompass a number of similar schemes administered by organisations throughout the UK. The plaques erected are made in a variety of designs, shapes, materials and colours: some are blue, others are not. However, the term "blue plaque" is often used informally to encompass all such schemes. The "official" scheme traces its origins to that launched in 1866 in London, on the initiative of the politician William Ewart, to mark the homes and workplaces of famous people. It has been administe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aspirin
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. For pain or fever, effects typically begin within 30 minutes. Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. One common adverse effect is an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections because of the risk of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bayer
Bayer AG (, commonly pronounced ; ) is a German multinational corporation, multinational pharmaceutical and biotechnology company and one of the largest pharmaceutical companies in the world. Headquartered in Leverkusen, Bayer's areas of business include pharmaceuticals; consumer healthcare products, agricultural chemicals, seeds and biotechnology products. The company is a component of the Euro Stoxx 50 stock market index. Bayer was founded in 1863 in Barmen as a partnership between dye salesman Friedrich Bayer and dyer Friedrich Weskott. As was common in this era, the company was established as a dyestuffs producer. The versatility of aniline chemistry led Bayer to expand their business into other areas, and in 1899 Bayer launched the compound acetylsalicylic acid under the trademarked name Aspirin. In 1904 Bayer received a trademark for the "Bayer Cross" logo, which was subsequently stamped onto each aspirin tablet, creating an iconic product that is still sold by Bayer. Ot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arthur Eichengrün
Arthur Eichengrün (13 August 1867 – 23 December 1949) was a German Jewish chemist, materials scientist, and inventor. He is known for developing the highly successful anti-gonorrhea drug Protargol, the standard treatment for 50 years until the adoption of antibiotics, and for his pioneering contributions in plastics: co-developing (with Theodore Becker) the first soluble cellulose acetate materials in 1903, called "Cellit", and creating processes for the manufacture of these materials which were influential in the development of injection moulding. During World War I his relatively non-flammable synthetic cellulose acetate lacquers, marketed under the name "Cellon", were important in the aircraft industry. He contributed to photochemistry by inventing the first process for the production and development of cellulose acetate film, which he patented with Becker. Eichengrün claimed to have directed the initial synthesis of aspirin in 1897, but his claim has been disputed. For m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Felix Hoffmann
Felix Hoffmann (21 January 1868 – 8 February 1946) was a German chemist notable for re-synthesising diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin". He is also credited with synthesizing aspirin, though whether he did this under his own initiative or under the instruction of Arthur Eichengrün is contested. Career Felix Hoffmann was born on 21 January 1868 in Ludwigsburg, Germany, the son of an industrialist. In 1889, he started studying chemistry at the Ludwig Maximilian University of Munich to study pharmacy and ended it in 1890 with the pharmaceutical state exam. In 1891 he graduated magna cum laude from the University of Munich. Two years later he earned his doctorate, also magna cum laude, after completing his thesis entitled "On certain derivatives of dihydroanthracene". In 1894, he joined Bayer as a research chemist. On 10 August 1897 Hoffmann synthesized acetylsa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetyl Chloride
Acetyl chloride (CH3COCl) is an acyl chloride derived from acetic acid. It belongs to the class of organic compounds called acid halides. It is a colorless, corrosive, volatile liquid. Its formula is commonly abbreviated to AcCl. Synthesis On an industrial scale, the reaction of acetic anhydride with hydrogen chloride produces a mixture of acetyl chloride and acetic acid: :(CH3CO)2O + HCl → CH3COCl + CH3CO2H Laboratory routes Acetyl chloride was first prepared in 1852 by French chemist Charles Gerhardt by treating potassium acetate with phosphoryl chloride. Acetyl chloride is produced in the laboratory by the reaction of acetic acid with chlorodehydrating agents such as PCl3, PCl5, SO2Cl2, phosgene, or SOCl2. However, these methods usually give acetyl chloride contaminated by phosphorus or sulfur impurities, which may interfere with the organic reactions. Other methods When heated, a mixture of dichloroacetyl chloride and acetic acid gives acetyl chloride. It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium Salicylate
Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by refluxing methyl salicylate (wintergreen oil) with an excess of sodium hydroxide. Properties Sodium salicylate is of the salicylate family. Uses It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It is also a potential replacement for aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ... for people sensitive to it. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons. References External links Chem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS (Fellow of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Parker, 2nd Earl Of Macclesfield
George Parker, 2nd Earl of Macclesfield, PRS (c. 1695 or 1697 – 17 March 1764) was an English peer and astronomer. Styled Viscount Parker from 1721 to 1732, he was Member of Parliament (MP) for Wallingford from 1722 to 1727, but his interests were not in politics. In 1722, he became a fellow of the Royal Society, and he spent most of his time in astronomical observations at his Oxfordshire seat, Shirburn Castle, which had been bought by his father in 1716; here he built an observatory and a chemical laboratory. He was very prominent in making the case in Parliament for the Calendar (New Style) Act 1750, with which the Kingdom of Great Britain and the British Empire changed from the Julian calendar to the Gregorian calendar in 1752. When his son ran for parliament as a Whig in 1754, his role in the calendar reform was one of many issues raised by the son's Tory opponents; one of Hogarth's satirical series of paintings about these elections (1755) is the only sour ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolite
In biochemistry, a metabolite is an intermediate or end product of metabolism. The term is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene exemplifies a primary metabolite produced large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin, which is created from the primary metabolite tryptophan. Some sugars are metabolites, such as fructose or glucose, which are both p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salicylic Acid
Salicylic acid is an organic compound with the formula HOC6H4CO2H. A colorless, bitter-tasting solid, it is a precursor to and a metabolite of aspirin (acetylsalicylic acid). It is a plant hormone, and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental teratogen. The name is from Latin ''salix'' for willow tree. It is an ingredient in some anti-acne products. Salts and esters of salicylic acid are known as salicylates. Uses Medicine Salicylic acid as a medication is commonly used to remove the outer layer of the skin. As such, it is used to treat warts, psoriasis, acne vulgaris, ringworm, dandruff, and ichthyosis. Similar to other hydroxy acids, salicylic acid is an ingredient in many skincare products for the treatment of seborrhoeic dermatitis, acne, psoriasis, calluses, corns, keratosis pilaris, acanthosis nigricans, ichthyosis, and warts. Uses in manufacturing Salicylic acid is used as a food preservative ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
