Edward Albert Schafer
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Edward Albert Schafer
Sir Edward Albert Sharpey-Schafer FRS FRSE FRCP LLD (2 June 1850 – 29 March 1935) was an English physiologist. He is regarded as a founder of endocrinology: in 1894 he discovered and demonstrated the existence of adrenaline together with George Oliver, and he also coined the term "endocrine" for the secretions of the ductless glands. Schafer's method of artificial respiration is named after him. Schafer coined the word "insulin" after theorising the absence of a single substance produced by the pancreas was responsible for diabetes mellitus. Biography He was born Edward Albert Schäfer, in Hornsey in London, the third son of Jessie Brown and James William Henry Schäfer, a merchant born in Hamburg, who had come to England as a young man, and was a naturalised citizen. His mother was English. The family lived in Highgate in north-west London. Edward was educated at Clewer House School. From 1868 he studied medicine at University College London, where he was tau ...
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Hornsey
Hornsey is a district of north London, England in the London Borough of Haringey The London Borough of Haringey (pronounced , same as Harringay) is a London borough in North London, classified by some definitions as part of Inner London, and by others as part of Outer London. It was created in 1965 by the amalgamation o .... It is an inner-suburban, for the most part residential, area centred north of Charing Cross. It adjoins green spaces Queen's Wood and Alexandra Park, London, Alexandra Park to the north. Known locally as Hornsey Village (to avoid confusion with the original borough of Hornsey) it is London's oldest recorded village, first recorded in 1202, according to the Place Names of Middlesex. Locale Hornsey is relatively old, being originally a village that grew up along Hornsey High Street, at the eastern end of which is the churchyard and tower of the formeSt Mary's parish church which was first mentioned i1291 At the western end is Priory Park, Haringe ...
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Royal College Of Physicians
The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1518, the RCP is the oldest medical college in England. It set the first international standard in the classification of diseases, and its library contains medical texts of great historical interest. The college is sometimes referred to as the Royal College of Physicians of London to differentiate it from other similarly named bodies. The RCP drives improvements in health and healthcare through advocacy, education and research. Its 40,000 members work in hospitals and communities across over 30 medical specialties with around a fifth based in over 80 countries worldwide. The college hosts six training faculties: the Faculty of Forensic and Legal Medicine, the Faculty for Pharmaceutical Medicine, the Faculty of Occupational Medicine the Fac ...
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Highgate
Highgate ( ) is a suburban area of north London at the northeastern corner of Hampstead Heath, north-northwest of Charing Cross. Highgate is one of the most expensive London suburbs in which to live. It has two active conservation organisations, the ''Highgate Society'' and the ''Highgate Neighbourhood Forum'' to protect and enhance its character and amenities. Until late Victorian times it was a distinct village outside London, sitting astride the main road to the north. The area retains many green expanses including the eastern part of Hampstead Heath, three ancient woods, Waterlow Park and the eastern-facing slopes known as Highgate bowl. At its centre is Highgate village, largely a collection of Georgian shops, pubs, restaurants, residential streets, and the Sacred Spirits Distillery interspersed with diverse landmarks such as St Michael's Church and steeple, St. Joseph's Church and its green copper dome, Highgate School (1565), Jacksons Lane arts centre housed in a Gra ...
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Hamburg
(male), (female) en, Hamburger(s), Hamburgian(s) , timezone1 = Central (CET) , utc_offset1 = +1 , timezone1_DST = Central (CEST) , utc_offset1_DST = +2 , postal_code_type = Postal code(s) , postal_code = 20001–21149, 22001–22769 , area_code_type = Area code(s) , area_code = 040 , registration_plate = , blank_name_sec1 = GRP (nominal) , blank_info_sec1 = €123 billion (2019) , blank1_name_sec1 = GRP per capita , blank1_info_sec1 = €67,000 (2019) , blank1_name_sec2 = HDI (2018) , blank1_info_sec2 = 0.976 · 1st of 16 , iso_code = DE-HH , blank_name_sec2 = NUTS Region , blank_info_sec2 = DE6 , website = , footnotes ...
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Edward Albert Sharpey-Schafer
Sir Edward Albert Sharpey-Schafer FRS FRSE FRCP LLD (2 June 1850 – 29 March 1935) was an English physiologist. He is regarded as a founder of endocrinology: in 1894 he discovered and demonstrated the existence of adrenaline together with George Oliver, and he also coined the term "endocrine" for the secretions of the ductless glands. Schafer's method of artificial respiration is named after him. Schafer coined the word "insulin" after theorising the absence of a single substance produced by the pancreas was responsible for diabetes mellitus. Biography He was born Edward Albert Schäfer, in Hornsey in London, the third son of Jessie Brown and James William Henry Schäfer, a merchant born in Hamburg, who had come to England as a young man, and was a naturalised citizen. His mother was English. The family lived in Highgate in north-west London. Edward was educated at Clewer House School. From 1868 he studied medicine at University College London, where he was taught by th ...
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Diabetes Mellitus
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ...
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Pancreas
The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e. it has both an endocrine and a digestive exocrine function. 99% of the pancreas is exocrine and 1% is endocrine. As an endocrine gland, it functions mostly to regulate blood sugar levels, secreting the hormones insulin, glucagon, somatostatin, and pancreatic polypeptide. As a part of the digestive system, it functions as an exocrine gland secreting pancreatic juice into the duodenum through the pancreatic duct. This juice contains bicarbonate, which neutralizes acid entering the duodenum from the stomach; and digestive enzymes, which break down carbohydrates, proteins, and fats in food entering the duodenum from the stomach. Inflammation of the pancreas is known as pancreatitis, with common causes including chronic alcohol use and gallstones. Becaus ...
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Insulin
Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially o ...
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Artificial Respiration
Artificial ventilation (also called artificial respiration) is a means of assisting or stimulating respiration, a metabolic process referring to the overall exchange of gases in the body by pulmonary ventilation, external respiration, and internal respiration. It may take the form of manually providing air for a person who is not breathing or is not making sufficient respiratory effort, or it may be mechanical ventilation involving the use of a mechanical ventilator to move air in and out of the lungs when an individual is unable to breathe on their own, for example during surgery with general anesthesia or when an individual is in a coma or trauma. Types Manual methods Pulmonary ventilation (and hence external parts of respiration) is achieved through manual insufflation of the lungs either by the rescuer blowing into the patient's lungs (mouth-to-mouth resuscitation), or by using a mechanical device to do so. This method of insufflation has been proved more effective than meth ...
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George Oliver (physician)
George Oliver (13 April 1841 – 27 December 1915) was an English physician. He was born in Middleton-in-Teesdale, County Durham, the second son of W. Oliver, a surgeon. He attended the boarding school in Gainford, Yorkshire and was then medically educated at University College, London and University College Hospital, where he qualified MB in 1865 and MD in 1873. He moved to Harrogate, Yorkshire and ran an extensive practice there from 1876 until his retirement in 1908. In 1887 he was elected a fellow of the Royal College of Physicians and in 1896 delivered their Croonian Lecture on the subject of the circulation of the blood. In 1904 he founded the Oliver-Sharpey lectureship ''to promote physiological research by observation and experiment, and to encourage the application of physiological knowledge to the prevention and cure of disease and the prolongation of life'' (The lectureship was founded in honor of William Sharpey William Sharpey FRS FRSE LLD (1 April 1802 – 11 ...
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Adrenaline
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands and by a small number of neurons in the medulla oblongata. It plays an essential role in the fight-or-flight response by increasing blood flow to muscles, heart output by acting on the SA node, pupil dilation response, and blood sugar level. It does this by binding to alpha and beta receptors. It is found in many animals, including humans, and some single-celled organisms. It has also been isolated from the plant ''Scoparia dulcis'' found in Northern Vietnam. Medical uses As a medication, it is used to treat several conditions, including allergic reaction anaphylaxis, cardiac arrest, and superficial bleeding. Inhaled adrenaline may be used to improve the symptoms of croup. It may also be used for asthma when other treatments are not eff ...
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Endocrinology
Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Specializations include behavioral endocrinology and comparative endocrinology. The endocrine system consists of several glands, all in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. Therefore, endocrine glands are regarded as ductless glands. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target orga ...
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