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ERAP2
Endoplasmic reticulum aminopeptidase 2 is an aminopeptidase in humans involved in antigen presentation. It is encoded by the ERAP2 gene. Function ERAP1 and ERAP2 are Aminopeptidases, able to trim precursors to antigenic peptides in the endoplasmic reticulum. They hydrolyze N-terminal amino acids of proteins or peptide substrates so the Major histocompatibility complex (MHC) class I can present them to CD8+ T cells. ERAP2 plays a central role in antigen presentation and impacts the response of at least 4 cytokines: It is positively correlated with CCL3, which is involved in the recruitment of neutrophils upon infection, whereas it is inversely correlated with granulocyte colony-stimulating factor , interleukin-1β and IL-10. Genetics Mutations in the ERAP2 gene were found in DNA extracts derived from the skeletons of people who died shortly before, during or soon after the Black Death 1348 in three London cemeteries, including East Smithfield plague cemetery and from Den ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ERAP1
Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, also known as endoplasmic reticulum aminopeptidase 1 (ARTS-1), is a protein which in humans is encoded by the ''ARTS-1'' gene. Endoplasmic reticulum amino peptidase 1 is active in the endoplasmic reticulum, which is involved in protein processing and transport. This protein is an aminopeptidase, which is an enzyme that cleaves peptides at the N-terminal into smaller fragments called amino acids. Nomenclature ARTS1 is also known as: * ER aminopeptidase 1 (ERAP1) the name accepted by the Hugo Gene Nomenclature Committee * ER aminopeptidase associated with antigen processing (ERAAP) in mice * Adipocyte-derived leucine aminopeptidase (ALAP) * Puromycin-insensitive leucine aminopeptidase (PILS-AP) Function ERAP1 has two major functions in the immune system: *First, ERAP1 cleaves several proteins called cytokine receptors on the surface of cells. Cleaving these receptors reduces their ability to transmit c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminopeptidase
Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides (exopeptidases). They are widely distributed throughout the animal and plant kingdoms and are found in many subcellular organelles, in cytosol, and as membrane components. Aminopeptidases are used in essential cellular functions. Many, but not all, of these peptidases are zinc metalloenzymes. Some aminopeptidases are monomeric, and others are assemblies of relatively high mass (50 kDa) subunits. cDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here. Amino acid sequences determined directly or deduced from cDNAs indicate some amino acid sequence homologies in organisms as diverse as ''Escherichia coli'' and mammals, particularly in catalytically important residues or in residues involved in metal ion binding. One important aminopeptidas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interleukin-1β
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the ''IL1B'' gene."Catabolin" is the name given by Jeremy Saklatvala for IL-1 alpha. There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β. Function The fever-producing property of human leukocytic pyrogen (interleukin 1) was purified by Dinarello in 1977 with a specific activity of 10–20 nanograms/kg. In 1979, Dinarello reported that purified human leukocytic pyrogen was the same molecule that was described by Igal Gery in 1972. He named it lymphocyte-activating factor (LAF) because it was a lymphocyte mitogen. It was not until 1984 that interleukin 1 was discovered to consist of two distinct proteins, now called interleukin-1 a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Major Histocompatibility Complex
The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules. This locus got its name because it was discovered via the study of transplanted tissue compatibility. Later studies revealed that tissue rejection due to incompatibility is only a facet of the full function of MHC molecules: binding an antigen derived from self-proteins, or from pathogens, and bringing the antigen presentation to the cell surface for recognition by the appropriate T-cells. MHC molecules mediate the interactions of leukocytes, also called white blood cells (WBCs), with other leukocytes or with body cells. The MHC determines donor compatibility for organ transplant, as well as one's susceptibility to autoimmune diseases. In a cell, protein molecules of the host's own phenotype or of other biologic entities ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crohn’s Disease
Crohn's disease is a type of inflammatory bowel disease (IBD) that may affect any segment of the gastrointestinal tract. Symptoms often include abdominal pain, diarrhea (which may be bloody if inflammation is severe), fever, abdominal distension, and weight loss. Complications outside of the gastrointestinal tract may include anemia, skin rashes, arthritis, inflammation of the eye, and fatigue. The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum. Bowel obstruction may occur as a complication of chronic inflammation, and those with the disease are at greater risk of colon cancer and small bowel cancer. While the precise causes of Crohn's disease (CD) are unknown, it is believed to be caused by a combination of environmental, immune, and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system defends the gastrointestinal tract, possibly targeting microbial a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yersinia Pestis
''Yersinia pestis'' (''Y. pestis''; formerly '' Pasteurella pestis'') is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both ''Yersinia pseudotuberculosis'' and ''Yersinia enterocolitica''. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea (''Xenopsylla cheopis''). It causes the disease plague, which caused the first plague pandemic and the Black Death, the deadliest pandemic in recorded history. Plague takes three main forms: pneumonic, septicemic, and bubonic. ''Yersinia pestis'' is a parasite of its host, the rat flea, which is also a parasite of rats, hence ''Y. pestis'' is a hyperparasite. ''Y. pestis'' was discovered in 1894 by Alexandre Yersin, a Swiss/French physician and bacteriologist from the Pasteur Institute, during an epidemic of the plague in Hong Kong. Yersin was a member of the Pasteur school of thought. Kitasato Shibasaburō, a Japanese bacteriologist who practised Koch's me ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
East Smithfield
East Smithfield is a small locality in the London Borough of Tower Hamlets, east London, and also a short street, a part of the A1203 road. Once broader in scope, the name came to apply to the part of the ancient parish of St Botolph without Aldgate that was outside of the City of London. The old Royal Mint and the eastern part of St Katherine's Docks are located in the district. The street The street runs eastward from Tower Hill, with the name changing to The Highway after quarter of a mile. The street is on the route of both the London Marathon and the London Triathlon. At one time the street was known as ''Upper East Smithfield'' with the eastern part of St Katharine's Way (the part within East Smithfield) known as ''Lower East Smithfield''. History of the district Civil and ecclesiastical administration Portsoken Ward John Stow recounts the origin of the area from the ''Liber Trinitae'', where the Saxon King Edgar was petitioned by 13 knights to grant them the wastela ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Black Death
The Black Death (also known as the Pestilence, the Great Mortality or the Plague) was a bubonic plague pandemic occurring in Western Eurasia and North Africa from 1346 to 1353. It is the most fatal pandemic recorded in human history, causing the deaths of people, peaking in Europe from 1347 to 1351. Bubonic plague is caused by the bacterium ''Yersinia pestis'' spread by fleas, but it can also take a secondary form where it is spread by person-to-person contact via aerosols causing septicaemic or pneumonic plagues. The Black Death was the beginning of the second plague pandemic. The plague created religious, social and economic upheavals, with profound effects on the course of European history. The origin of the Black Death is disputed. The pandemic originated either in Central Asia or East Asia before spreading to Crimea with the Golden Horde army of Jani Beg as he was besieging the Genoese trading port of Kaffa in Crimea (1347). From Crimea, it was most likely carried ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
IL-10 Family
The IL10 family is a family of interleukins. In addition to IL-10, it includes IL-19, IL-20, IL-22, IL-24 and IL-26. Some sources also include the interferons IL-28 and IL-29. The IL-10 family are helical cytokines categorized based on their specific similarities and can be classified as class 2 cytokines. IL-10 Family Biological activity IL-10 family - is one of the important types of cytokines, that can stop the inflammation. In general. these cytokines have a helical structure of homodimers. The difference that the members of IL-10 family have between each other is that they have various receptor-binding residues, which help with interaction with specific cytokine receptors. The features of the IL-10 family consists of their genomic structure being similar, their primary and secondary protein structures being similar, their a clustering of encoding genes, and their utilization the similar receptor complexes. IL-10 Interleukin 10 is produced by regulatory T ly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CCL3
Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the ''CCL3'' gene. Function CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5. Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4). CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Granulocyte Colony-stimulating Factor
Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim. G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. Biological function G-CSF is produced by endothelium, macrophages, and a number of other immune cells. The natural human glycoprotein exists in two forms, a 174- and 177-amino-acid-long protein of molecular weight 19,600 grams per mole. The more-abundant and more-active 174-amino acid form has been used in the development of pharmaceutical products by recombinant DNA (rDNA) technology. ;Whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
