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EDAR
Ectodysplasin A receptor (EDAR) is a protein that in humans is encoded by the EDAR gene. EDAR is a cell surface receptor for ectodysplasin A which plays an important role in the development of ectodermal tissues such as the skin. It is structurally related to members of the TNF receptor superfamily. Function ''EDAR'' and other genes provide instructions for making proteins that work together during embryonic development. These proteins form part of a signaling pathway that is critical for the interaction between two cell layers, the ectoderm and the mesoderm. In the early embryo, these cell layers form the basis for many of the body's organs and tissues. Ectoderm-mesoderm interactions are essential for the proper formation of several structures that arise from the ectoderm, including the skin, hair, nails, teeth, and sweat glands. Clinical significance Mutation in this gene have been associated with hypohidrotic ectodermal dysplasia, a disorder characterized by a lower de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypohidrotic Ectodermal Dysplasia
Hypohidrotic ectodermal dysplasia is one of about 150 types of ectodermal dysplasia in humans. Before birth, these disorders result in the abnormal development of structures including the skin, hair, nails, teeth, and sweat glands.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . Presentation Most people with hypohidrotic ectodermal dysplasia have a reduced ability to sweat (hypohidrosis) because they have fewer sweat glands than normal or their sweat glands do not function properly. Sweating is a major way that the body controls its temperature; as sweat evaporates from the skin, it cools the body. An inability to sweat can lead to a dangerously high body temperature (hyperthermia) particularly in hot weather. In some cases, hyperthermia can cause life-threatening medical problems. Affected individuals tend to have sparse scalp and body hair (hypotrichosis). The hair is often light-coloured, brittle, and slow-growing. This c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sinodonty And Sundadonty
In anthropology, Sinodonty and Sundadonty are two patterns of features widely found in the dentitions of different populations in East Asia and Southeast Asia. These two patterns were identified by anthropologist Christy G. Turner II as being within the greater "Mongoloid dental complex". The combining forms ''Sino-'' and ''Sunda-'' refer to China and Sundaland, respectively, while refers to teeth. Proto-sundadonty hypothesis Tsunehiko Hanihara (1993) believed that the dental features of Aboriginal Australians have the characteristic of high frequencies of "''evolutionarily conservative characteristics,''" which he called the "proto-sundadont" pattern, as he believed that the dental pattern of Aboriginal Australians was ancestral to that of Southeast Asians.Hanihara, Tsunehiko. (1993). Craniofacial Features of Southeast Asians and Jomonese: A Reconsideration of Their Microevolution Since the Late Pleistocene. ''Anthropological Science, 101''(1). Page 26. Retrieved March 8, 20 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lapa Do Santo
Lapa do Santo is an archaeological site located in the northern part of the Lagoa Santa karst, in the state of Minas Gerais in east-central Brazil. It documents human presence since ca. 12000 years ago presenting three discrete occupation phases that correspond to the early, middle and late Holocene. Llithic technology, zooarchaeology, and multi- isotopic analyses indicate groups of hunter gathers with low mobility and a subsistence strategy focused on gathering plant foods and hunting small and mid-sized mammals. The use of Lapa do Santo as an interment ground started between 10.3-10.6 cal kyBP with primary burials. Between 9.4-9.6 cal kyBP central elements in the treatment of the dead were tooth removal, mutilation, defleshing, exposure to fire and possibly cannibalism, all to reduce the body ahead of reburial of the remains while adhering to strict rules. In the absence of monumental architecture or grave goods, these groups were using parts of fresh corpses to elaborate th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ectodysplasin A
Ectodysplasin A (EDA) is a protein that in humans is encoded by the EDA gene. Ectodysplasin A is a transmembrane protein of the TNF family which plays an important role in the development of ectodermal tissues such as skin in humans. It is recognized by the ectodysplasin A receptor. Function The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Along with c-Met, it has been shown to be involved in the differentiation of anatomical placodes, precursors of scales, feathers and hair follicles in vertebrates. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms A protein isoform, or "protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TNF Receptor
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. In their active form, the majority of TNF receptors form trimeric complexes in the plasma membrane. Accordingly, most TNF receptors contain transmembrane domains (TMDs), although some can be cleaved into soluble forms (e.g. TNFR1), and some lack a TMD entirely (e.g. DcR3). In addition, most TNF receptors require specific Signal transducing adaptor protein, adaptor protein such as TRADD, TRAF, RIP kinase, RIP and FADD for downstream signalling. TNF receptors are primarily involved in apoptosis and inflammation, but they can also take part in other signal transduction pathways, such as Cell proliferation, proliferation, survival, and Cellular differentiation, differentiation. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Upward Sun River Site
The Upward Sun River site, or Xaasaa Na’, is a Late Pleistocene archaeological site associated with the Paleo-Arctic tradition, located in the Tanana River Valley, Alaska. Dated to around 11,500 BP, Upward Sun River is the site of the oldest human remains discovered on the American side of Beringia. The site was first discovered in 2006. The layer with the human remains at Upward Sun River is most similar to the level 6 layer from Ushki Lake, Kamchatka. Both sites are the only Beringian burials found so far from that period. Etymology The name of the site, Upward Sun River, is a direct translation of the Middle Tanana name for the site, ''Xaasaa Na’''. The Middle Tanana name was recorded from the mother of a mother-daughter pair, two of the last remaining speakers of Middle Tanana, during an interview in the 1960s. Human remains The first excavation at Upward Sun River in 2010 yielded the cremated remains of a 3-year-old individual. The individual had been cremated insid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell-surface Receptors
The cell membrane (also known as the plasma membrane (PM) or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of all cells from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures. The membrane also contains membrane proteins, including integral proteins that span the membrane and serve as membrane transporters, and peripheral proteins that loosely attach to the outer (peripheral) side of the cell membrane, acting as enzymes to facilitate interaction with the cell's environment. Glycolipids embedded in the outer lipid layer serve a similar purpose. The cell membrane controls the movement of substances in and out of cells and organelles, being selectively permeable to ions a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteins
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residues ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ectodysplasin A2 Receptor
Tumor necrosis factor receptor superfamily member 27 is a protein that in humans is encoded by the ''EDA2R'' gene. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine Cysteine (symbol Cys or C; ) is a semiessential proteinogenic amino acid with the formula . The thiol side chain in cysteine often participates in enzymatic reactions as a nucleophile. When present as a deprotonated catalytic residue, sometime ...-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack suffici ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anzick-1
Anzick-1 is a Paleo-Indian male infant whose remains were found in south central Montana, United States, in 1968, and date to 13,000–12,850 years BP. The child was found with more than 115 tools made of stone and antlers and dusted with red ocher, suggesting an honorary burial. Anzick-1 is the only human who has been discovered from the Clovis Complex, and is the first ancient Native American genome to be fully sequenced. Paleogenomic analysis of the remains revealed Siberian ancestry and a close genetic relationship to modern Native Americans, including those of Central and South America. These findings support the hypothesis that modern Native Americans are descended from Asian populations who crossed Beringia between 23,000 and 14,000 years ago. Anzick-1's discovery and subsequent analysis has been controversial. The remains were found on private land, so compliance with the Native American Graves Protection and Repatriation Act (NAGPRA) was not required in their study. S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scythian
The Scythians or Scyths, and sometimes also referred to as the Classical Scythians and the Pontic Scythians, were an ancient Eastern * : "In modern scholarship the name 'Sakas' is reserved for the ancient tribes of northern and eastern Central Asia and Eastern Turkestan to distinguish them from the related Massagetae of the Aral region and the Scythians of the Pontic steppes. These tribes spoke Iranian languages, and their chief occupation was nomadic pastoralism." * : "Near the end of the 19th century V.F. Miller (1886, 1887) theorized that the Scythians and their kindred, the Sauromatians, were Iranian-speaking peoples. This has been a popular point of view and continues to be accepted in linguistics and historical science .. * : "From the end of the 7th century B.C. to the 4th century B.C. the Central- Eurasian steppes were inhabited by two large groups of kin Iranian-speaking tribes – the Scythians and Sarmatians .. * : "All contemporary historians, archeologists and li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
