E3A Expressway (Japan)
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E3A Expressway (Japan)
E3A may refer to: * Haplogroup E3a (Y-DNA), Y-DNA haplogroup E3a * UBE3A, Ubiquitin protein ligase E3A * Boeing E-3 Sentry, an American military aircraft * Minamikyushu Expressway, route E3A in Japan. {{Letter-NumberCombDisambig ...
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Haplogroup E3a (Y-DNA)
Haplogroup E-M2 (or E1b1a) is a human Y-chromosome DNA haplogroup. It is primarily distributed in sub-Saharan Africa. E-M2 is the predominant subclade in West-Central Africa, Southern Africa and the African Great Lakes, and occurs at moderate frequencies in North Africa and Middle East. E-M2 has several subclades, but many of these subhaplogroups are included in either E-L485 or E-U175. E-M2 is especially common in native Africans speaking Niger-Congo languages and was spread to Southern and Eastern Africa through the Bantu expansion. Origins The discovery of two SNPs (V38 and V100) by Trombetta et al. (2011) significantly redefined the E-V38 phylogenetic tree. This led the authors to suggest that E-V38 may have originated in East Africa. E-V38 joins the West African-affiliated E-M2 and the northern East African-affiliated E-M329 with an earlier common ancestor who, like E-P2, may have also originated in East Africa. The downstreams SNP E-M180 possibly originated on the moist s ...
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UBE3A
Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the ''UBE3A'' gene. This enzyme is involved in targeting proteins for degradation within cells. Protein degradation is a normal process that removes damaged or unnecessary proteins and helps maintain the normal functions of cells. Ubiquitin protein ligase E3A attaches a small marker protein called ubiquitin to proteins that should be degraded. Cellular structures called proteasomes recognize and digest proteins tagged with ubiquitin. Both copies of the UBE3A gene are active in most of the body's tissues. In most neurons, however, only the copy inherited from a person's mother (the maternal copy) is normally active; this is known as paternal imprinting. Recent evidence shows that at least some glial cells and neurons may exhibit biallelic expression of UBE3A. Further work is thus needed to delineate a complete map of UBE3A imprinting in humans and mod ...
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Boeing E-3 Sentry
The Boeing E-3 Sentry is an American airborne early warning and control (AEW&C) aircraft developed by Boeing. E-3s are commonly known as AWACS (Airborne Warning and Control System). Derived from the Boeing 707 airliner, it provides all-weather surveillance, command, control, and communications, and is used by the United States Air Force, NATO, French Air and Space Force, Royal Saudi Air Force and Chilean Air Force. The E-3 is distinguished by the distinctive rotating radar dome (rotodome) above the fuselage. Production ended in 1992 after 68 aircraft had been built. In the mid-1960s, the U.S. Air Force (USAF) was seeking an aircraft to replace its piston-engined Lockheed EC-121 Warning Star, which had been in service for over a decade. After issuing preliminary development contracts to three companies, the USAF picked Boeing to construct two airframes to test Westinghouse Electric and Hughes's competing radars. Both radars used pulse-Doppler technology, with Westinghouse's ...
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