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Dynamic Causal Modelling
Dynamic causal modeling (DCM) is a framework for specifying models, fitting them to data and comparing their evidence using Bayes factor, Bayesian model comparison. It uses nonlinear State space, state-space models in continuous time, specified using Stochastic differential equation, stochastic or ordinary differential equations. DCM was initially developed for testing hypotheses about Dynamical system, neural dynamics. In this setting, differential equations describe the interaction of neural populations, which directly or indirectly give rise to functional neuroimaging data e.g., functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG) or electroencephalography (EEG). Parameters in these models quantify the directed influences or effective connectivity among neuronal populations, which are estimated from the data using Bayesian inference, Bayesian statistical methods. Procedure DCM is typically used to estimate the coupling among brain regions and the changes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bayes Factor
The Bayes factor is a ratio of two competing statistical models represented by their marginal likelihood, and is used to quantify the support for one model over the other. The models in questions can have a common set of parameters, such as a null hypothesis and an alternative, but this is not necessary; for instance, it could also be a non-linear model compared to its linear approximation. The Bayes factor can be thought of as a Bayesian analog to the likelihood-ratio test, but since it uses the (integrated) marginal likelihood instead of the maximized likelihood, both tests only coincide under simple hypotheses (e.g., two specific parameter values). Also, in contrast with null hypothesis significance testing, Bayes factors support evaluation of evidence ''in favor'' of a null hypothesis, rather than only allowing the null to be rejected or not rejected. Although conceptually simple, the computation of the Bayes factor can be challenging depending on the complexity of the model ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Generalized Filtering
Generalized filtering is a generic Bayesian filtering scheme for nonlinear state-space models. It is based on a variational principle of least action, formulated in generalized coordinates of motion. Note that "generalized coordinates of motion" are related to—but distinct from—generalized coordinates as used in (multibody) dynamical systems analysis. Generalized filtering furnishes posterior densities over hidden states (and parameters) generating observed data using a generalized gradient descent on variational free energy, under the Laplace assumption. Unlike classical (e.g. Kalman-Bucy or particle) filtering, generalized filtering eschews Markovian assumptions about random fluctuations. Furthermore, it operates online, assimilating data to approximate the posterior density over unknown quantities, without the need for a backward pass. Special cases include variational filtering, dynamic expectation maximization and generalized predictive coding. Definition Definition: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
General Linear Model
The general linear model or general multivariate regression model is a compact way of simultaneously writing several multiple linear regression models. In that sense it is not a separate statistical linear model. The various multiple linear regression models may be compactly written as : \mathbf = \mathbf\mathbf + \mathbf, where Y is a matrix with series of multivariate measurements (each column being a set of measurements on one of the dependent variables), X is a matrix of observations on independent variables that might be a design matrix (each column being a set of observations on one of the independent variables), B is a matrix containing parameters that are usually to be estimated and U is a matrix containing errors (noise). The errors are usually assumed to be uncorrelated across measurements, and follow a multivariate normal distribution. If the errors do not follow a multivariate normal distribution, generalized linear models may be used to relax assumptions about Y and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bayesian Model Reduction
Bayesian model reduction is a method for computing the evidence and posterior over the parameters of Bayesian models that differ in their priors. A full model is fitted to data using standard approaches. Hypotheses are then tested by defining one or more 'reduced' models with alternative (and usually more restrictive) priors, which usually – in the limit – switch off certain parameters. The evidence and parameters of the reduced models can then be computed from the evidence and estimated ( posterior) parameters of the full model using Bayesian model reduction. If the priors and posteriors are normally distributed, then there is an analytic solution which can be computed rapidly. This has multiple scientific and engineering applications: these include scoring the evidence for large numbers of models very quickly and facilitating the estimation of hierarchical models ( Parametric Empirical Bayes). Theory Consider some model with parameters \theta and a prior probability densi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laplace's Method
In mathematics, Laplace's method, named after Pierre-Simon Laplace, is a technique used to approximate integrals of the form :\int_a^b e^ \, dx, where f(x) is a twice-differentiable function, ''M'' is a large number, and the endpoints ''a'' and ''b'' could possibly be infinite. This technique was originally presented in . In Bayesian statistics, Laplace's approximation can refer to either approximating the posterior normalizing constant with Laplace's method or approximating the posterior distribution with a Gaussian centered at the maximum a posteriori estimate. Laplace approximations play a central role in the integrated nested Laplace approximations method for fast approximate Bayesian inference. The idea of Laplace's method Suppose the function f(x) has a unique global maximum at ''x''0. Let M>0 be a constant and consider the following two functions: :\begin g(x) &= Mf(x) \\ h(x) &= e^ \end Note that ''x''0 will be the global maximum of g and h as well. Now observe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variational Bayesian Methods
Variational Bayesian methods are a family of techniques for approximating intractable integrals arising in Bayesian inference and machine learning. They are typically used in complex statistical models consisting of observed variables (usually termed "data") as well as unknown parameters and latent variables, with various sorts of relationships among the three types of random variables, as might be described by a graphical model. As typical in Bayesian inference, the parameters and latent variables are grouped together as "unobserved variables". Variational Bayesian methods are primarily used for two purposes: #To provide an analytical approximation to the posterior probability of the unobserved variables, in order to do statistical inference over these variables. #To derive a lower bound for the marginal likelihood (sometimes called the ''evidence'') of the observed data (i.e. the marginal probability of the data given the model, with marginalization performed over unobserved v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hodgkin–Huxley Model
The Hodgkin–Huxley model, or conductance-based model, is a mathematical model that describes how action potentials in neurons are initiated and propagated. It is a set of nonlinear differential equations that approximates the electrical characteristics of excitable cells such as neurons and muscle cells. It is a continuous-time dynamical system. Alan Hodgkin and Andrew Huxley described the model in 1952 to explain the ionic mechanisms underlying the initiation and propagation of action potentials in the squid giant axon. They received the 1963 Nobel Prize in Physiology or Medicine for this work. Basic components The typical Hodgkin–Huxley model treats each component of an excitable cell as an electrical element (as shown in the figure). The lipid bilayer is represented as a capacitance (Cm). Voltage-gated ion channels are represented by electrical conductances (''g''''n'', where ''n'' is the specific ion channel) that depend on both voltage and time. Leak channels are rep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Morris–Lecar Model
The Morris–Lecar model is a biological neuron model developed by Catherine Morris and Harold Lecar to reproduce the variety of oscillatory behavior in relation to Ca++ and K+ conductance in the muscle fiber of the giant barnacle . Morris–Lecar neurons exhibit both class I and class II neuron excitability. History Catherine Morris (b. 24 December 1949) is a Canadian biologist. She won a Commonwealth scholarship to study at Cambridge University, where she earned her PhD in 1977. She became a professor at the University of Ottawa in the early 1980s. As of 2015, she is an emeritus professor at the University of Ottawa. Harold Lecar (18 October 1935 – 4 February 2014) was an American professor of biophysics and neurobiology at the University of California Berkeley. He graduated with his PhD in physics from Columbia University in 1963. Experimental method The Morris–Lecar experiments relied on the voltage clamp method established by Keynes ''et al.'' (1973). The principal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Predictive Coding
In neuroscience, predictive coding (also known as predictive processing) is a theory of brain function which postulates that the brain is constantly generating and updating a "mental model" of the environment. According to the theory, such a mental model is used to predict input signals from the senses that are then compared with the actual input signals from those senses. With the rising popularity of representation learning, the theory is being actively pursued and applied in machine learning and related fields. The phrase 'predictive coding' is also used in several other disciplines such as signal-processing technologies and law in loosely-related or unrelated senses. Origins Theoretical ancestors to predictive coding date back as early as 1860 with Helmholtz's concept of unconscious inference. Unconscious inference refers to the idea that the human brain fills in visual information to make sense of a scene. For example, if something is relatively smaller than another object i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sigmoid Function
A sigmoid function is a mathematical function having a characteristic "S"-shaped curve or sigmoid curve. A common example of a sigmoid function is the logistic function shown in the first figure and defined by the formula: :S(x) = \frac = \frac=1-S(-x). Other standard sigmoid functions are given in the Examples section. In some fields, most notably in the context of artificial neural networks, the term "sigmoid function" is used as an alias for the logistic function. Special cases of the sigmoid function include the Gompertz curve (used in modeling systems that saturate at large values of x) and the ogee curve (used in the spillway of some dams). Sigmoid functions have domain of all real numbers, with return (response) value commonly monotonically increasing but could be decreasing. Sigmoid functions most often show a return value (y axis) in the range 0 to 1. Another commonly used range is from −1 to 1. A wide variety of sigmoid functions including the logistic and hype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convolution
In mathematics (in particular, functional analysis), convolution is a operation (mathematics), mathematical operation on two function (mathematics), functions ( and ) that produces a third function (f*g) that expresses how the shape of one is modified by the other. The term ''convolution'' refers to both the result function and to the process of computing it. It is defined as the integral of the product of the two functions after one is reflected about the y-axis and shifted. The choice of which function is reflected and shifted before the integral does not change the integral result (see #Properties, commutativity). The integral is evaluated for all values of shift, producing the convolution function. Some features of convolution are similar to cross-correlation: for real-valued functions, of a continuous or discrete variable, convolution (f*g) differs from cross-correlation (f \star g) only in that either or is reflected about the y-axis in convolution; thus it is a cross-c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
