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Donald Pinkel, M.D.
Donald Paul Pinkel (September 7, 1926 – March 9, 2022) was an American physician who specialized in pediatric hematology and oncology. Pinkel made contributions to cures for several forms of childhood cancer, including leukemia. He was the first director of St. Jude Children's Research Hospital in Memphis, Tennessee, serving from 1962 to 1973. He also authored or co-authored numerous books, chapters in books, and journal articles. He received many awards and recognitions for his research work, including the Albert Lasker Award for Clinical Medical Research in 1972, the Kettering Prize for cancer research in 1986, and the Pollin Prize for Pediatric Research in 2003. Early life and career Pinkel was born in Buffalo, New York, on September 7, 1926. His father, Lawrence, worked as a hardware salesman; his mother, Anne (Richardson), was a housewife. Pinkel graduated from Canisius High School in 1944, and enlisted in the US Navy later that year. As part of the V-12 Navy College ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buffalo, New York
Buffalo is the second-largest city in the U.S. state of New York (behind only New York City) and the seat of Erie County. It is at the eastern end of Lake Erie, at the head of the Niagara River, and is across the Canadian border from Southern Ontario. With a population of 278,349 according to the 2020 census, Buffalo is the 78th-largest city in the United States. The city and nearby Niagara Falls together make up the two-county Buffalo–Niagara Falls Metropolitan Statistical Area (MSA), which had an estimated population of 1.1 million in 2020, making it the 49th largest MSA in the United States. Buffalo is in Western New York, which is the largest population and economic center between Boston and Cleveland. Before the 17th century, the region was inhabited by nomadic Paleo-Indians who were succeeded by the Neutral, Erie, and Iroquois nations. In the early 17th century, the French began to explore the region. In the 18th century, Iroquois land surrounding Buffalo Creek ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canisius College
Canisius College is a private Jesuit college in Buffalo, New York. It was founded in 1870 by Jesuits from Germany and is named after St. Peter Canisius. Canisius offers more than 100 undergraduate majors and minors, and around 34 master's and certificate programs. History Canisius has its roots in the Jesuit community that arose from disputed ownership of St. Louis Church in Buffalo in 1851."ST. MICHAEL'S CHURCH, JESUITS' ORIGINAL BASE; IN AREA, TO MARK 150TH YEAR WITH MASS." Buffalo News (New York). (September 29, 2001 Saturday, FINAL EDITION ): 863 words. LexisNexis Academic. Web. Date Accessed: 2016/05/03. Rev. Lucas Caveng, a German Jesuit, along with 19 families from St. Louis Church, founded St. Michael's Church on Washington St. The college followed, primarily for serving sons of German immigrants, along with the high school in 1870, first at 434 Ellicott St. and next to St. Michael's."MASS TO MARK 125TH YEAR OF CANISIUS COLLEGE, HIGH." Buffalo News (New York). (Sep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Resistance
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved. Antimicrobial resistance and antineoplastic resistance challenge clinical care and drive research. When an organism is resistant to more than one drug, it is said to be multidrug-resistant. The development of antibiotic resistance in particular stems from the drugs targeting only specific bacterial molecules (almost always proteins). Because the drug is ''so'' specific, any mutation in these molecules will interfere with or negate its destructive effect, resulting in antibiotic resistance. Furthermore, there is mounting concern over the abuse of antibiotics in the farming of livestock, which in the European Union alone accounts for three times the volume dispensed to humans – leading to development of super-resi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. In most cases, the cause is unknown. Genetic risk factors may include Down syndrome, Li-Fraumeni syndrome, or neurofibromatosis type 1. Environmental risk factors may include significant radiation exposure or prior chemotherapy. Evidence regarding electromagnetic fields or pesticides is unclear. Some hypothesize that an abnormal immune response to a common infection may be a trigger. The underlying mechanism involves multiple genetic mutations that results in rapid cell division. The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Danny Thomas
Danny Thomas (born Amos Muzyad Yaqoob Kairouz; January 6, 1912 – February 6, 1991) was an American actor, singer, nightclub comedian, producer, and philanthropist. He created and starred in one of the most successful and long-running situation comedies in the history of American network television, the ''Danny Thomas Show''. In addition to guest roles on many of the comedy, talk, and musical variety programs of his time, his legacy includes a lifelong dedication to fundraising for charity. Most notably, he was the founder of St. Jude Children's Research Hospital in Memphis, Tennessee, a leading center in pediatric medicine with a focus on pediatric cancer. St. Jude now has affiliate hospitals in eight other American cities as of early 2020. Already a successful entertainer, Thomas began his film career in 1947, playing opposite child actress Margaret O'Brien in '' The Unfinished Dance'' (1947) and '' Big City'' (1948). He then starred in the long-running television sitc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smithsonian (magazine)
''Smithsonian'' is the official journal published by the Smithsonian Institution in Washington, D.C. The first issue was published in 1970. History The history of ''Smithsonian'' began when Edward K. Thompson, the retired editor of ''Life (magazine), Life'' magazine, was asked by the then-Secretary of the Smithsonian, S. Dillon Ripley, to produce a magazine "about things in which the Smithsonian [Institution] is interested, might be interested or ought to be interested." Thompson would later recall that his philosophy for the new magazine was that it "would stir curiosity in already receptive minds. It would deal with history as it is relevant to the present. It would present art, since true art is never dated, in the richest possible reproduction. It would peer into the future via coverage of social progress and of science and technology. Technical matters would be digested and made intelligible by skilled writers who would stimulate readers to reach upward while not turning the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roswell Park Comprehensive Cancer Center
Roswell Park Comprehensive Cancer Center is a cancer research and treatment center located in Buffalo, New York. Founded by surgeon Roswell Park in 1898, the center was the first in the United States to specifically focus on cancer research. The center is usually called Roswell Park in short form. The center, which conducts clinical research on cancer as well as the development new drugs, provides advanced treatment for all forms of adult and pediatric cancer, and serves as a member of the National Comprehensive Cancer Network. Roswell Park Comprehensive Cancer Center is currently the only upstate New York facility to hold the National Cancer Institute designation of "comprehensive cancer center". The Roswell Park campus, spread out in 15 separate buildings of approximately two million square feet, occupies on the Buffalo Niagara Medical Campus (BNMC) in downtown Buffalo, and includes of space equally distributed between clinical programs and research/education functions. A sep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminopterin
Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities. Uses Discovered by Yellapragada Subbarow, the drug was first used by Sidney Farber in 1947 to induce remissions among children with leukemia. Aminopter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sidney Farber
Sidney Farber (September 30, 1903 – March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy for his work using folic acid antagonists to combat leukemia, which led to the development of other chemotherapeutic agents against other malignancies. Farber was also active in cancer research advocacy and fundraising, most notably through his establishment of the Jimmy Fund, a foundation dedicated to pediatric research in childhood cancers. The Dana–Farber Cancer Institute is named after him. Early life He was born in Buffalo, New York, to Jewish parents Simon and Matilda (Goldstein) Farber. He was the third of 14 children. He was the younger brother of the noted philosopher and University of Buffalo professor Marvin Farber (1901–1980). Farber graduated from University at Buffalo, The State University of New York, or SUNY Buffalo, in 1923. Farber Hall, built in 1953 on the South Campus of SUNY Buffalo, is named for him. In the m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poliomyelitis
Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia. These symptoms usually pass within one or two weeks. A less common symptom is permanent paralysis, and possible death in extreme cases.. Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to that which the person had during the initial infection. Polio occurs naturally only in humans. It is highly infectious, and is spread from person to person either through fecal-oral transmission (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via the oral-oral route. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts
Massachusetts (Massachusett language, Massachusett: ''Muhsachuweesut [Massachusett writing systems, məhswatʃəwiːsət],'' English: , ), officially the Commonwealth of Massachusetts, is the most populous U.S. state, state in the New England region of the Northeastern United States. It borders on the Atlantic Ocean and Gulf of Maine to the east, Connecticut and Rhode Island to the south, New Hampshire and Vermont to the north, and New York (state), New York to the west. The state's capital and List of municipalities in Massachusetts, most populous city, as well as its cultural and financial center, is Boston. Massachusetts is also home to the urban area, urban core of Greater Boston, the largest metropolitan area in New England and a region profoundly influential upon American History of the United States, history, academia, and the Economy of the United States, research economy. Originally dependent on agriculture, fishing, and trade. Massachusetts was transformed into a manuf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Corps (United States Army)
The Medical Corps (MC) of the U.S. Army is a staff corps (non-combat specialty branch) of the U.S. Army Medical Department (AMEDD) consisting of commissioned medical officers – physicians with either an M.D. or a D.O. degree, at least one year of post-graduate clinical training, and a state medical license. The MC traces its earliest origins to the first physicians recruited by the Medical Department of the Army, created by the Second Continental Congress in 1775. The US Congress made official the designation "Medical Corps" in 1908, although the term had long been in use informally among the Medical Department's regular physicians. Currently, the MC consists of over 4,400 active duty physicians representing all the specialties and subspecialties of civilian medicine. They may be assigned to fixed military medical facilities, to deployable combat units or to military medical research and development duties. They are considered fully deployable soldiers. The Chief of the Med ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
