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DisProt
DisProt is a manually curated biological database of intrinsically disordered proteins (IDPs) and regions (IDRs). DisProt annotations cover state information on the protein but also, when available, its state transitions, interactions and functional aspects of disorder detected by specific experimental methods. DisProt is hosted and maintained in the BioComputing UP laboratory (Dept. of Biomedical Sciences, University of Padua). Website The latest DisProt version, DisProt 9, includes more than 2300 protein entries and more than 4500 pieces of evidence of structural state, state transitions, interactions and functions, along with more than 2500 scientific publications annotated. Biocuration in DisProt DisProt entries are annotated by professional and community biocurators from experimental data published in scientific literature. The DisProt home page features examples of DisProt entries, i.e. ''p53'' and ''Catenin beta-1'', along with entries of proteins belonging to the Severe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DisProt 8 Logo
DisProt is a manually curated biological database of intrinsically disordered proteins (IDPs) and regions (IDRs). DisProt annotations cover state information on the protein but also, when available, its state transitions, interactions and functional aspects of disorder detected by specific experimental methods. DisProt is hosted and maintained in the BioComputing UP laboratory (Dept. of Biomedical Sciences, University of Padua). Website The latest DisProt version, DisProt 9, includes more than 2300 protein entries and more than 4500 pieces of evidence of structural state, state transitions, interactions and functions, along with more than 2500 scientific publications annotated. Biocuration in DisProt DisProt entries are annotated by professional and community biocurators from experimental data published in scientific literature. The DisProt home page features examples of DisProt entries, i.e. ''p53'' and ''Catenin beta-1'', along with entries of proteins belonging to the Severe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DisProt 9
DisProt is a manually curated biological database of intrinsically disordered proteins (IDPs) and regions (IDRs). DisProt annotations cover state information on the protein but also, when available, its state transitions, interactions and functional aspects of disorder detected by specific experimental methods. DisProt is hosted and maintained in the BioComputing UP laboratory (Dept. of Biomedical Sciences, University of Padua). Website The latest DisProt version, DisProt 9, includes more than 2300 protein entries and more than 4500 pieces of evidence of structural state, state transitions, interactions and functions, along with more than 2500 scientific publications annotated. Biocuration in DisProt DisProt entries are annotated by professional and community biocurators from experimental data published in scientific literature. The DisProt home page features examples of DisProt entries, i.e. ''p53'' and ''Catenin beta-1'', along with entries of proteins belonging to the SARS-C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intrinsically Disordered Proteins
In molecular biology, an intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure, typically in the absence of its macromolecular interaction partners, such as other proteins or RNA. IDPs range from fully unstructured to partially structured and include random coil, molten globule-like aggregates, or flexible linkers in large multi-domain proteins. They are sometimes considered as a separate class of proteins along with globular, fibrous and membrane proteins. IDPs are a very large and functionally important class of proteins and their discovery has disproved the idea that three-dimensional structures of proteins must be fixed to accomplish their biological functions. For example, IDPs have been identified to participate in weak multivalent interactions that are highly cooperative and dynamic, lending them importance in DNA regulation and in cell signaling. Many IDPs can also adopt a fixed three-dimensional structure after ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Database
Biological databases are libraries of biological sciences, collected from scientific experiments, published literature, high-throughput experiment technology, and computational analysis. They contain information from research areas including genomics, proteomics, metabolomics, microarray gene expression, and phylogenetics. Information contained in biological databases includes gene function, structure, localization (both cellular and chromosomal), clinical effects of mutations as well as similarities of biological sequences and structures. Biological databases can be classified by the kind of data they collect (see below). Broadly, there are molecular databases (for sequences, molecules, etc.), functional databases (for physiology, enzyme activities, phenotypes, ecology etc), taxonomic databases (for species and other taxonomic ranks), images and other media, or specimens (for museum collections etc.) Databases are important tools in assisting scientists to analyze and explain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Padua
The University of Padua ( it, Università degli Studi di Padova, UNIPD) is an Italian university located in the city of Padua, region of Veneto, northern Italy. The University of Padua was founded in 1222 by a group of students and teachers from Bologna. Padua is the second-oldest university in Italy and the world's fifth-oldest surviving university. In 2010, the university had approximately 65,000 students. In 2021, it was ranked second "best university" among Italian institutions of higher education with more than 40,000 students according to Censis institute, and among the best 200 universities in the world according to ARWU. History The university is conventionally said to have been founded in 1222 when a large group of students and professors left the University of Bologna in search of more academic freedom ('Libertas scholastica'). The first subjects to be taught were law and theology. The curriculum expanded rapidly, and by 1399 the institution had divided in two: a ''Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a provisional name, 2019 novel coronavirus (2019-nCoV), and has also been called the human coronavirus 2019 (HCoV-19 or hCoV-19). First identified in the city of Wuhan, Hubei, China, the World Health Organization declared the outbreak a public health emergency of international concern on January 30, 2020, and a pandemic on March 11, 2020. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is contagious in humans. SARS‑CoV‑2 is a virus of the species ''severe acute respiratory syndrome–related coronavirus'' (SARSr-CoV), related to the SARS-CoV-1 virus that caused the 2002–2004 SARS outbreak. Despite its close relation to SARS-CoV-1, its closest known relatives, with which it forms a sister group, are the derived SAR ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AngularJS
AngularJS is a discontinued free and open-source JavaScript-based web framework for developing single-page applications. It was maintained mainly by Google and a community of individuals and corporations. It aimed to simplify both the development and the testing of such applications by providing a framework for client-side model–view–controller (MVC) and model–view–viewmodel (MVVM) architectures, along with components commonly used in web applications and progressive web applications. AngularJS was used as the frontend of the MEAN stack, that consisted of MongoDB database, Express.js web application server framework, AngularJS itself (or Angular), and Node.js server runtime environment. As of January 1, 2022, Google no longer updates AngularJS to fix security, browser compatibility, or jQuery issues. The Angular team recommends upgrading to Angular (v2+) as the best path forward, but they also provided some other options. Overview The AngularJS framework worked by f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Machine Learning
Machine learning (ML) is a field of inquiry devoted to understanding and building methods that 'learn', that is, methods that leverage data to improve performance on some set of tasks. It is seen as a part of artificial intelligence. Machine learning algorithms build a model based on sample data, known as training data, in order to make predictions or decisions without being explicitly programmed to do so. Machine learning algorithms are used in a wide variety of applications, such as in medicine, email filtering, speech recognition, agriculture, and computer vision, where it is difficult or unfeasible to develop conventional algorithms to perform the needed tasks.Hu, J.; Niu, H.; Carrasco, J.; Lennox, B.; Arvin, F.,Voronoi-Based Multi-Robot Autonomous Exploration in Unknown Environments via Deep Reinforcement Learning IEEE Transactions on Vehicular Technology, 2020. A subset of machine learning is closely related to computational statistics, which focuses on making predicti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Ontology
The Gene Ontology (GO) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access to all aspects of the data provided by the project, and to enable functional interpretation of experimental data using the GO, for example via enrichment analysis. GO is part of a larger classification effort, the Open Biomedical Ontologies, being one of the Initial Candidate Members of the OBO Foundry. Whereas gene nomenclature focuses on gene and gene products, the Gene Ontology focuses on the function of the genes and gene products. The GO also extends the effort by using markup language to make the data (not only of the genes and their products but also of curated attributes) machine reada ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
