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Diglyceride Acyltransferase
Diglyceride acyltransferase (or O-acyltransferase), DGAT, catalyzes the formation of triglycerides from diacylglycerol and fatty acyl-CoA]. The reaction catalyzed by DGAT is considered the terminal and only committed step in triglyceride synthesis. The conversion is essential for intestinal absorption (i.e. DGAT1) and adipose tissue formation (i.e. DGAT2). The protein is homologous to other membrane-bound O-acyltransferases. Isoforms Two DGAT isozymes are encoded by the genes DGAT1 and DGAT2. Although both isozymes catalyze similar reactions, they share no sequence homology.DGAT1is mainly located in absorptive enterocyte cells that line the intestine and duodenum where it reassembles triglycerides that were decomposed through lipolysis in the process of intestinal absorption. DGAT1 reconstitutes triglycerides in a committed step after which they are packaged together with cholesterol and proteins to form chylomicrons.DGAT2is mainly located in fat, liver and skin cells. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DGAT1
Diacylglycerol O-acyltransferase 1 is an enzyme that in humans is encoded by the DGAT1 gene. Function This gene encodes a multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases. This enzyme is essential for lactation in mice, and mutations in this gene affect the composition and volume of milk produced by both cattle and goats. Without this gene activity, infants who have a mutation in this gene are incapable of breaking down fat. This lack of capability to break down fat causes diarrhea and vomiting which eventually causes FTT (Failure to Thrive) and need of TPN (Total Parenteral Nutrition) if not given correct formula. Further this will cause protein losing enteropathy and very low albumin. See also * Diglyceride acyltra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |