|
David Webb (pharmacologist)
David John Webb, (born 1 September 1953) is a British physician, scientist and clinical pharmacologist, who currently holds the Christison Chair of Therapeutics and Clinical Pharmacology at the University of Edinburgh. He was appointed to the Christison Chair of Therapeutics and Clinical Pharmacology at the University of Edinburgh in 1995, and from 1998 to 2001 he was Head of the University's Department of Medical Sciences there. He established its Centre for Cardiovascular Science in 2000. Early life and education David Webb was born on 1 September 1953 to Alfred And Edna Webb, and was educated at Dulwich College before studying medicine at the London Hospital Medical School. Following junior appointments, Webb worked at the Medical Research Council Blood Pressure Unit in Glasgow and trained as a cardiovascular physician and clinical pharmacologist at St George's Hospital and Medical School. Career and research Webb moved to a senior lectureship in medicine at the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dulwich College
Dulwich College is a 2–19 independent, day and boarding school for boys in Dulwich, London, England. As a public school, it began as the College of God's Gift, founded in 1619 by Elizabethan actor Edward Alleyn, with the original purpose of educating 12 poor scholars. It began to grow into a large school from 1857, and took its current form in 1870 when it moved into its current premises. Admission by examination is mainly into years 3, 7, 9, and 12 (i.e. ages 7, 11, 13, and 16 years old) to the Junior, Lower, Middle and Upper Schools into which the college is divided. It is a member of both the Headmasters' and Headmistresses' Conference and the Eton Group. History 1619: The College of God's Gift On 21 June 1619 the College of God's Gift was established in Dulwich by Edward Alleyn with the signing letters patent by James I.Hodges, S. (1981), ''God's Gift: A Living History of Dulwich College'', pp. 3–5 (Heinemann: London). The term "Dulwich College" was used colloquia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Schools Council
The Medical Schools Council is an organisation that represents 41 medical schools and one post graduate school in the United Kingdom. The membership is made up of the heads, or deans of the medical schools. It was formerly known as the Council of Heads of Medical Schools. History The origins of the Medical Schools Council dates back to 1947, when the Conference of Deans of Provincial Medical Schools was formed. In 1989, this merged with the Conference of Deans of London Medical Schools, and in 2006 the organisation changed its name to the Medical Schools Council. Widening participation The Medical Schools Council is involved in aiding medical schools improve access for applicants with a broader range of backgrounds. In the late nineties, the Medical Schools Council (then CHMS) looked at admission data and concluded that men and people from ethnic minorities were suffering from discrimination when they applied to medical schools. It was noted that the gender variation may "reflec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Royal Society Of Edinburgh
Fellowship of the Royal Society of Edinburgh (FRSE) is an award granted to individuals that the Royal Society of Edinburgh, Scotland's national academy of science and letters, judged to be "eminently distinguished in their subject". This society received a royal charter in 1783, allowing for its expansion. Elections Around 50 new fellows are elected each year in March. there are around 1,650 Fellows, including 71 Honorary Fellows and 76 Corresponding Fellows. Fellows are entitled to use the post-nominal letters FRSE, Honorary Fellows HonFRSE, and Corresponding Fellows CorrFRSE. Disciplines The Fellowship is split into four broad sectors, covering the full range of physical and life sciences, arts, humanities, social sciences, education, professions, industry, business and public life. A: Life Sciences * A1: Biomedical and Cognitive Sciences * A2: Clinical Sciences * A3: Organismal and Environmental Biology * A4: Cell and Molecular Biology B: Physical, Engineering and I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Of Medical Sciences
The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to advance biomedical and health research and its translation into benefits for society. The academy consists of a group of around 1200 Fellows elected from fields across the biomedical sciences. The academy seeks ultimately to advance medical science and improve health by investing in talented researchers, engaging people on health-related issues and providing expert impartial advice. its president is Dame Anne Johnson. History The academy was established in 1998 following the recommendations of a working group chaired by Michael Atiyah, former president of the Royal Society. A single national organisation was formed to support biomedical scientists and clinical academics working together to promote advances in medical science. It is one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Academy Of Medical Sciences
Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of their achievements". Fellowship Fellows are entitled to use the post-nominal letters Post-nominal letters, also called post-nominal initials, post-nominal titles, designatory letters or simply post-nominals, are letters placed after a person's name to indicate that the individual holds a position, academic degree, accreditation, ... FMedSci; see :Fellows of the Academy of Medical Sciences (United Kingdom) for examples of fellows. References Fellows of learned societies of the United Kingdom Academy of Medical Sciences (United Kingdom) {{Award-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Royal College Of Physicians
The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1518, the RCP is the oldest medical college in England. It set the first international standard in the classification of diseases, and its library contains medical texts of great historical interest. The college is sometimes referred to as the Royal College of Physicians of London to differentiate it from other similarly named bodies. The RCP drives improvements in health and healthcare through advocacy, education and research. Its 40,000 members work in hospitals and communities across over 30 medical specialties with around a fifth based in over 80 countries worldwide. The college hosts six training faculties: the Faculty of Forensic and Legal Medicine, the Faculty for Pharmaceutical Medicine, the Faculty of Occupational Medicine the Fac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renal Disease
Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests. Nephrosis is non-inflammatory kidney disease. Nephritis and nephrosis can give rise to nephritic syndrome and nephrotic syndrome respectively. Kidney disease usually causes a loss of kidney function to some degree and can result in kidney failure, the complete loss of kidney function. Kidney failure is known as the end-stage of kidney disease, where dialysis or a kidney transplant is the only treatment option. Chronic kidney disease is defined as prolonged kidney abnormalities (functional and/or structural in nature) that last for more than three months. Acute kidney disease is now termed acute kidney injury and is marked by the sudden reduction in kidney function over seven days. In 2007, about one in eight Am ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endothelin Receptor Antagonist
An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: * selective ETA receptor antagonists ( sitaxentan, ambrisentan, atrasentan, BQ-123, zibotentan, edonentan), which affect endothelin A receptors. * dual antagonists (bosentan, macitentan, tezosentan), which affect both endothelin A and B receptors. * selective ETB receptor antagonists (BQ-788 and A192621) which affect endothelin B receptors are used in research but have not yet reached the clinical trial stage. Sitaxentan, ambrisentan and bosentan are mainly used for the treatment of pulmonary arterial hypertension, while atrasentan is an experimental anti-cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ... drug. References {{cardiova ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endothelin
Endothelins are peptides with receptor (biochemistry), receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins are normally kept in balance by other mechanisms, but when gene expression, overexpressed, they contribute to high blood pressure (hypertension), heart disease, and potentially other diseases. Endothelins are 21-amino acid vasoconstriction, vasoconstricting peptides produced primarily in the endothelium having a key role in smooth muscle, vascular homeostasis. Endothelins are implicated in vascular diseases of several organ systems, including the heart, lungs, kidneys, and brain. As of 2018, endothelins remain under extensive basic research, basic and clinical research to define their roles in several organ systems. Etymology Endothelins derived the name from their isolation in cultured endothelial cells. Isoforms There are three isoforms of the peptide (identified as ET-1, -2, -3), each encoded by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renin Inhibitor
Renin inhibitors are pharmaceutical drugs inhibiting the activity of renin that is responsible for hydrolyzing angiotensinogen to angiotensin I, which in turn reduces the formation of angiotensin II that facilitates blood pressure. Renin inhibitor is often preceded by ''direct'', called ''direct'' renin inhibitor in order to distinguish its mechanism from other renin–angiotensin–aldosterone system-interfering drugs such as angiotensin converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs) and aldosterone receptor antagonists. These drugs inhibit the first and rate-limiting step of the renin–angiotensin–aldosterone system (RAAS), namely the conversion of angiotensinogen to angiotensin I. This leads to a totality in absence of angiotensin II based on the rationale that renin only acts to inhibit this step unlike Angiotensin Converting Enzyme which is also involved in other biochemical reactions. Since the 1970s, scientists have been trying to develop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Renin
Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that increases the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and causes arterial vasoconstriction. Thus, it increases the body's mean arterial blood pressure. Renin is not commonly referred to as a hormone, albeit it having a receptor, the (pro)renin receptor, also known as the renin receptor and prorenin receptor (see also below), as well as enzymatic activity with which it hydrolyzes angiotensinogen to angiotensin I. Biochemistry and physiology Structure The primary structure of renin precursor consists of 406 amino acids with a pre- and a pro-segment carrying 20 and 46 amino acids, respectively. Mature renin contains 340 amino acids and has a mass of 37 kDa. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phases Of Clinical Research
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays. Summary Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory authority for use in the general population. Phase IV trials are 'post-marketing' or 'surveillance' studies conducted to monitor safety over sever ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
