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David Tyrrell (physician)
David Arthur John Tyrrell (19 June 1925 – 2 May 2005) was a British virologist who was the director of the Common Cold Unit, which investigated viruses that caused common colds. He discovered the first human coronavirus (designated B814) in 1965. With June Almeida he made the first comparative study of human and chicken coronaviruses in 1967, and invented the name coronavirus in 1968. Biography Tyrrell was born on 19 June 1925 to Sidney Tyrrell and Agnes Kate Blewett. He had a younger brother Andrew. He attended elementary schools at Ashford, Middlesex. His family moved to Sheffield in 1940, where he completed secondary education at King Edward VII School. While studying medicine at the University of Sheffield he suffered from a detached retina, which meant he was exempted from military conscription, and had a lifelong preference for monocular microscopes. He graduated in 1948 and earned membership of the Royal College of Physicians in 1949. During those years he worked as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wendy Barclay
Wendy Sue Fox (née Barclay) is a British virologist. She is currently head of Department of Infectious Disease and Chair in Influenza Virology at Imperial College London. She leads a team of scientists studying the influenza virus and its physiology and morphology to discover novel vaccines. In particular, they are trying to understand more about influenza virus mutations, and how they can allow scientists to create new vaccines against possible flu pandemics. Education Barclay graduated with a Bachelor of Arts (BA) degree in Natural Sciences from the University of Cambridge. For a postgraduate study, she conducted medical research at the Common Cold Unit in Salisbury, supervised by David Tyrrell and Fred Brown, for which she was awarded a Doctor of Philosophy (PhD) from the University of Reading in 1988: her doctoral thesis was titled "The humoral immune response to rhinovirus infection". At Reading, she was involved in human challenge studies with rhinovirus, to study th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sheffield Royal Hospital
The Royal Hospital was an acute general hospital in Sheffield, South Yorkshire. It covered most of the block bounded to the north by West Street, to the east by Westfield Terrace, to the south by Devonshire Street and to the west by Eldon Street. History The facility had its origins in a public dispensary which opened in 1832. It became known as the Sheffield Public Dispensary Hospital after it was extended in 1860 and it became known as the Sheffield Public Hospital after it was extended again in 1870. The hospital was completely rebuilt in the early 1890s and was officially opened by the Duchess of York as the Sheffield Royal Hospital on 11 May 1895. A new nurses' home was completed in the late 1890s. The Mount Zion chapel on Westfield Terrace, with its impressive facade in Classical Revival style with projecting portico with pediment and a pair of giant Ionic columns in antis, was acquired in 1922. Once the chapel had been converted into an out-patients department, it was of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Coronavirus 229E
''Human coronavirus 229E'' (''HCoV-229E'') is a species of coronavirus which infects humans and bats. It is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the APN receptor. Along with Human coronavirus OC43 (a member of the '' Betacoronavirus'' genus), it is one of the viruses responsible for the common cold. HCoV-229E is a member of the genus '' Alphacoronavirus'' and subgenus ''Duvinacovirus''. Transmission HCoV-229E transmits via droplet-respiration and fomites. Signs and symptoms HCoV-229E is associated with a range of respiratory symptoms, ranging from the common cold to high-morbidity outcomes such as pneumonia and bronchiolitis. However, such high morbidity outcomes are almost always seen in cases with co-infection with other respiratory pathogens; there is a single published case report to date of a 229E infection that caused acute respiratory distress syndrome (ARDS) in an otherwise healthy patient having no detec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mouse Hepatitis Virus
Murine coronavirus (M-CoV) is a virus in the genus ''Betacoronavirus'' that infects mice. Belonging to the subgenus ''Embecovirus'', murine coronavirus strains are enterotropic or polytropic. Enterotropic strains include mouse hepatitis virus (MHV) strains D, Y, RI, and DVIM, whereas polytropic strains, such as JHM and A59, primarily cause hepatitis, enteritis, and encephalitis. Murine coronavirus is an important pathogen in the laboratory mouse and the laboratory rat. It is the most studied coronavirus in animals other than humans, and has been used as an animal disease model for many virological and clinical studies. Types Murine hepatitis virus Murine coronavirus was first discovered in 1949. The researchers isolated the virus from the brain, spinal cord, liver, lung, spleen, and kidney of a rat with symptoms of encephalitis and severe myelin injury, and gave it the strain name mouse hepatitis virus (MHV)-JHM. MHV is now the most studied coronavirus in animals other than huma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infectious Bronchitis Virus
''Avian coronavirus'' is a species of virus from the genus '' Gammacoronavirus'' that infects birds; since 2018, all gammacoronaviruses which infect birds have been classified as this single species. The strain of avian coronavirus previously known as infectious bronchitis virus (IBV) is the only coronavirus that infects chickens. It causes avian infectious bronchitis, a highly infectious disease that affects the respiratory tract, gut, kidney and reproductive system. IBV affects the performance of both meat-producing and egg-producing chickens and is responsible for substantial economic loss within the poultry industry. The strain of avian coronavirus previously classified as Turkey coronavirus causes gastrointestinal disease in turkeys. Classification IBV is in the genus '' Gammacoronavirus'', or group 3, with a non-segmented, positive-sense single-stranded RNA genome. It was previously the type species of its genus ''Igacovirus''. When there was only one genus of coronavir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
St Thomas's Hospital Medical School
St Thomas's Hospital Medical School in London was one of the oldest and most prestigious medical schools in the UK. The school was absorbed to form part of King's College London. History It was part of one of the oldest hospitals in London, St Thomas' Hospital established in 1173 but whose roots can be traced to the establishment of St Mary Overie Priory in 1106. According to historical records ''St Thomas's Hospital Medical School'' was founded in about 1550. It was admitted as a school of the University of London in 1900 but remained a constituent part of ''St Thomas' Hospital'' until 1948 when it formally became part of the university. In 1982 it merged with the medical school at Guy's Hospital to form the United Medical and Dental Schools of Guy's and St Thomas' Hospitals. In turn UMDS was absorbed by King's College London School of Medicine and Dentistry, but the dentists have since been split out into The Dental Institute. Name Unlike the hospital which in recent time ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
June Dalziel Almeida
June Dalziel Almeida (5 October 1930 – 1 December 2007) was a Scottish virologist, a pioneer in virus imaging, identification, and diagnosis. Her skills in electron microscopy earned her an international reputation. In 1964, Almeida was recruited by St Thomas's Hospital Medical School in London. By 1967, she had earned her Doctor of Science (Sc.D.) on the basis of her research and the resulting publications, while working in Canada, at Toronto's Ontario Cancer Institute and then in London at St Thomas's. she then continued her research at the Royal Postgraduate Medical School (RPGMS), which later became part of the Imperial College School of Medicine. Almeida succeeded in identifying viruses that were previously unknown, including—in 1966—a group of viruses that was later named coronavirus, due to their crown-like appearance. Her immune electron microscopy (IEM) innovations and insights contributed to research related to the diagnosis of hepatitis B, HIV, and rubella, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orthomyxoviridae
''Orthomyxoviridae'' (from Greek ὀρθός, ''orthós'' 'straight' + μύξα, ''mýxa'' 'mucus') is a family of negative-sense RNA viruses. It includes seven genera: ''Alphainfluenzavirus'', ''Betainfluenzavirus'', '' Gammainfluenzavirus'', '' Deltainfluenzavirus'', ''Isavirus'', ''Thogotovirus'', and ''Quaranjavirus''. The first four genera contain viruses that cause influenza in birds (see also avian influenza) and mammals, including humans. Isaviruses infect salmon; the thogotoviruses are arboviruses, infecting vertebrates and invertebrates (such as ticks and mosquitoes). The Quaranjaviruses are also arboviruses, infecting vertebrates (birds) and invertebrates (arthropods). The four genera of Influenza virus that infect vertebrates, which are identified by antigenic differences in their nucleoprotein and matrix protein, are as follows: * ''Alphainfluenzavirus'' infects humans, other mammals, and birds, and causes all flu pandemics * ''Betainfluenzavirus'' infects h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Medical Journal
''The BMJ'' is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). ''The BMJ'' has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Originally called the ''British Medical Journal'', the title was officially shortened to ''BMJ'' in 1988, and then changed to ''The BMJ'' in 2014. The journal is published by BMJ Publishing Group Ltd, a subsidiary of the British Medical Association (BMA). The editor-in-chief of ''The BMJ'' is Kamran Abbasi, who was appointed in January 2022. History The journal began publishing on 3 October 1840 as the ''Provincial Medical and Surgical Journal'' and quickly attracted the attention of physicians around the world through its publication of high-impact original research articles and unique case reports. The ''BMJ''s first editors were P. Hennis Green, lecturer on the diseases of children at the Hunterian School of Medicine, who also was its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lund University
, motto = Ad utrumque , mottoeng = Prepared for both , established = , type = Public research university , budget = SEK 9 billion Facts and figures Lund University web site. , head_label = Vice Chancellor , head = Erik Renström , academic_staff = 4,780 (2022) (academic staff, researchers and employed research students) , administrative_staff = 2,890 (2022) , students = 46 000 (29 000 full-time equivalents) [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Porton Down
Porton Down is a science park in Wiltshire, England, just northeast of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory (Dstl) – known for over 100 years as one of the UK's most secretive and controversial military research facilities, occupying – and a site of the UK Health Security Agency. It is also home to other private and commercial science organisations, and is expanding to attract other companies. Location Porton Down is located just northeast of the village of Porton near Salisbury, in Wiltshire, England. To the northwest lies the MoD Boscombe Down airfield operated by QinetiQ. On some maps, the land surrounding the complex is identified as a "Danger Area". History of government use Porton Down opened in 1916 as the War Department Experimental Station, shortly thereafter renamed the Royal Engineers Experimental Station, for testing chemical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rubella
Rubella, also known as German measles or three-day measles, is an infection caused by the rubella virus. This disease is often mild, with half of people not realizing that they are infected. A rash may start around two weeks after exposure and last for three days. It usually starts on the face and spreads to the rest of the body. The rash is sometimes itchy and is not as bright as that of measles. Swollen lymph nodes are common and may last a few weeks. A fever, sore throat, and fatigue may also occur. Joint pain is common in adults. Complications may include bleeding problems, testicular swelling, encephalitis, and inflammation of nerves. Infection during early pregnancy may result in a miscarriage or a child born with congenital rubella syndrome (CRS). Symptoms of CRS manifest as problems with the eyes such as cataracts, deafness, as well as affecting the heart and brain. Problems are rare after the 20th week of pregnancy. Rubella is usually spread from one person to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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