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David Sankoff
David Sankoff (born December 31, 1942) is a Canadian mathematician, bioinformatician, computer scientist and linguist. He holds the Canada Research Chair in Mathematical Genomics in the Mathematics and Statistics Department at the University of Ottawa, and is cross-appointed to the Biology Department and the School of Information Technology and Engineering. He was founding editor of the scientific journal ''Language Variation and Change'' (Cambridge) and serves on the editorial boards of a number of bioinformatics, computational biology and linguistics journals. Sankoff is best known for his pioneering contributions in computational linguistics and computational genomics. He is considered to be one of the founders of bioinformatics. In particular, he had a key role in introducing dynamic programming for sequence alignment and other problems in computational biology. In Pavel Pevzner's words, " Michael Waterman ">Michael_Waterman.html" ;"title="Michael Waterman">Michael Water ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Montreal
Montreal ( ; officially Montréal, ) is the List of the largest municipalities in Canada by population, second-most populous city in Canada and List of towns in Quebec, most populous city in the Provinces and territories of Canada, Canadian province of Quebec. Founded in 1642 as ''Fort Ville-Marie, Ville-Marie'', or "City of Mary", it is named after Mount Royal, the triple-peaked hill around which the early city of Ville-Marie is built. The city is centred on the Island of Montreal, which obtained its name from the same origin as the city, and a few much smaller peripheral islands, the largest of which is Île Bizard. The city is east of the national capital Ottawa, and southwest of the provincial capital, Quebec City. As of 2021, the city had a population of 1,762,949, and a Census Metropolitan Area#Census metropolitan areas, metropolitan population of 4,291,732, making it the List of the largest municipalities in Canada by population, second-largest city, and List of cen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleic Acid Secondary Structure
Nucleic acid secondary structure is the basepairing interactions within a single nucleic acid polymer or between two polymers. It can be represented as a list of bases which are paired in a nucleic acid molecule. The secondary structures of biological DNAs and RNAs tend to be different: biological DNA mostly exists as fully base paired double helices, while biological RNA is single stranded and often forms complex and intricate base-pairing interactions due to its increased ability to form hydrogen bonds stemming from the extra hydroxyl group in the ribose sugar. In a non-biological context, secondary structure is a vital consideration in the nucleic acid design of nucleic acid structures for DNA nanotechnology and DNA computing, since the pattern of basepairing ultimately determines the overall structure of the molecules. Fundamental concepts Base pairing In molecular biology, two nucleotides on opposite complementary DNA or RNA strands that are connected via hydrogen b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Biology
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers. History Bioinformatics, the analysis of informatics processes in biological systems, began in the early 1970s. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. This use of biological data pushed biological researchers to use computers to evaluate and compare large data sets in their own field. By 1982, researchers shared information via punch cards. The amount of data grew exponentially by the end of the 1980s, requiring new computational methods for quickly interpreting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sequence Alignment
In bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences. Aligned sequences of nucleotide or amino acid residues are typically represented as rows within a matrix. Gaps are inserted between the residues so that identical or similar characters are aligned in successive columns. Sequence alignments are also used for non-biological sequences, such as calculating the distance cost between strings in a natural language or in financial data. Interpretation If two sequences in an alignment share a common ancestor, mismatches can be interpreted as point mutations and gaps as indels (that is, insertion or deletion mutations) introduced in one or both lineages in the time since they diverged from one another. In sequence alignments of proteins, the degree of similarity between amino acids occupying a parti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dynamic Programming
Dynamic programming is both a mathematical optimization method and a computer programming method. The method was developed by Richard Bellman in the 1950s and has found applications in numerous fields, from aerospace engineering to economics. In both contexts it refers to simplifying a complicated problem by breaking it down into simpler sub-problems in a recursive manner. While some decision problems cannot be taken apart this way, decisions that span several points in time do often break apart recursively. Likewise, in computer science, if a problem can be solved optimally by breaking it into sub-problems and then recursively finding the optimal solutions to the sub-problems, then it is said to have ''optimal substructure''. If sub-problems can be nested recursively inside larger problems, so that dynamic programming methods are applicable, then there is a relation between the value of the larger problem and the values of the sub-problems.Cormen, T. H.; Leiserson, C. E.; Rives ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Genomics
Computational genomics refers to the use of computational and statistical analysis to decipher biology from genome sequences and related data, including both DNA and RNA sequence as well as other "post-genomic" data (i.e., experimental data obtained with technologies that require the genome sequence, such as genomic DNA microarrays). These, in combination with computational and statistical approaches to understanding the function of the genes and statistical association analysis, this field is also often referred to as Computational and Statistical Genetics/genomics. As such, computational genomics may be regarded as a subset of bioinformatics and computational biology, but with a focus on using whole genomes (rather than individual genes) to understand the principles of how the DNA of a species controls its biology at the molecular level and beyond. With the current abundance of massive biological datasets, computational studies have become one of the most important means to biologi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Computational Linguistics
Computational linguistics is an Interdisciplinarity, interdisciplinary field concerned with the computational modelling of natural language, as well as the study of appropriate computational approaches to linguistic questions. In general, computational linguistics draws upon linguistics, computer science, artificial intelligence, mathematics, logic, philosophy, cognitive science, cognitive psychology, psycholinguistics, anthropology and neuroscience, among others. Sub-fields and related areas Traditionally, computational linguistics emerged as an area of artificial intelligence performed by computer scientists who had specialized in the application of computers to the processing of a natural language. With the formation of the Association for Computational Linguistics (ACL) and the establishment of independent conference series, the field consolidated during the 1970s and 1980s. The Association for Computational Linguistics defines computational linguistics as: The term "comp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Journal
In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research. Content Articles in scientific journals are mostly written by active scientists such as students, researchers, and professors instead of professional journalists. There are thousands of scientific journals in publication, and many more have been published at various points in the past (see list of scientific journals). Most journals are highly specialized, although some of the oldest journals such as ''Nature'' publish articles and scientific papers across a wide range of scientific fields. Scientific journals contain articles that have been peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality and scientific validity. Although scientific journals are superficially similar to professional magazines, they are actually quite different. Issues of a scientific journal are rarely read casuall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioinformatics
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combines biology, chemistry, physics, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data. Bioinformatics has been used for '' in silico'' analyses of biological queries using computational and statistical techniques. Bioinformatics includes biological studies that use computer programming as part of their methodology, as well as specific analysis "pipelines" that are repeatedly used, particularly in the field of genomics. Common uses of bioinformatics include the identification of candidates genes and single nucleotide polymorphisms (SNPs). Often, such identification is made with the aim to better understand the genetic basis of disease, unique adaptations, desirable properties (e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weldon Memorial Prize
The Weldon Memorial Prize, also known as the Weldon Memorial Prize and Medal, is given yearly by the University of Oxford. The prize is to be awarded without regard to nationality or membership of any University to the person who, in the judgement of the electors, has, in the ten years next preceding the date of the award, published the most noteworthy contribution to the development of mathematical or statistical methods applied to problems in Biology. (Biology shall, for the purposes of this clause, be interpreted as including Zoology, Botany, Anthropology, Sociology, Psychology, and Medical Science.) It is named in honor of Walter Frank Raphael Weldon, former Linacre Professor of Zoology at the University. It was established through the efforts of Francis Galton and Karl Pearson. Although intended to be given yearly, it has in the past been given less often. Recipients * 1911 David Heron [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ISCB Senior Scientist Award
The ISCB Accomplishment by a Senior Scientist Award is an annual prize awarded by the International Society for Computational Biology for contributions to the field of computational biology. Laureates *2021 - Peer Bork *2020 - Steven Salzberg *2019 - Bonnie Berger *2018 - Ruth Nussinov *2017 - Pavel Pevzner *2016 - Søren Brunak *2015 - Cyrus Chothia *2014 - Gene Myers *2013 - David Eisenberg *2012 - Gunnar von Heijne *2011 - Michael Ashburner *2010 - Chris Sander *2009 - Webb Miller *2008 - David Haussler *2007 - Temple F. Smith *2006 - Michael Waterman *2005 - Janet Thornton Dame Janet Maureen Thornton, (born 23 May 1949) is a senior scientist and director emeritus at the European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL). She is one of the world's leading researche ... *2004 - David J. Lipman *2003 - David Sankoff References {{Reflist, 30em Bioinformatics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ISCB Fellow
ISCB Fellowship is an award granted to scientists that the International Society for Computational Biology (ISCB) judges to have made “outstanding contributions to the fields of computational biology and bioinformatics”. , there are 76 Fellows of the ISCB including Michael Ashburner, Alex Bateman, Bonnie Berger, Steven E. Brenner, Janet Kelso, Daphne Koller, Michael Levitt, Sarah Teichmann and Shoshana Wodak. See List of Fellows of the International Society for Computational Biology for a comprehensive listing. Fellows of the International Society for Computational Biology The first seven fellows of the ISCB were laureates of the ISCB Senior Scientist Award from 2003 to 2009: #Webb Miller Webb Colby Miller (born 1943) is a professor in the Department of Biology and the Department of Computer Science and Engineering at The Pennsylvania State University. Education Miller attended Whitman College, and received his Ph.D. in mathemati ... #David Haussler # Temple F. Smith # ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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