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David Ho
David Da-i Ho (; born November 3, 1952) is a Taiwanese-American AIDS researcher, physician, and virologist who has made a number of scientific contributions to the understanding and treatment of HIV infection. He is the founding scientific director of the Aaron Diamond AIDS Research Center and the Clyde and Helen Wu Professor of Medicine at Columbia University Vagelos College of Physicians and Surgeons. David Ho was born in Taichung, Taiwan, to Paul (), an engineer, and Sonia Ho (née Jiang) (). David Ho attended Taichung Municipal Guang-Fu Elementary School until sixth grade before immigrating to the United States with his mother and younger brother to unite with his father, who had already been in the US since 1957. He grew up in Los Angeles and graduated from John Marshall High School. He received his Bachelor of Science in biology with highest honors from the California Institute of Technology (1974) and MD from the Harvard-MIT Division of Health Sciences and Techno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Taichung
Taichung (, Wade–Giles: ''Tʻai²-chung¹'', pinyin: ''Táizhōng''), officially Taichung City, is a special municipality located in central Taiwan. Taichung has approximately 2.8 million residents and is the second most populous city of Taiwan, as well as the most populous city in Central Taiwan. It serves as the core of the Taichung–Changhua metropolitan area, the second largest metropolitan area in Taiwan. Located in the Taichung Basin, the city was initially developed from several scattered hamlets helmed by the Taiwanese indigenous peoples. It was constructed to be the new capital of Taiwan Province and renamed as " Taiwan-fu" in the late Qing dynastic era between 1887 and 1894. During the Japanese era from 1895, the urban planning of present-day city of Taichung was performed and developed by the Japanese. From the start of ROC rule in 1945, the urban area of Taichung was organized as a provincial city up until 25 December 2010, when the original provincial city and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Marshall High School (Los Angeles)
John Marshall High School is a public high school located in the Los Feliz district of the city of Los Angeles at 3939 Tracy Street in Los Angeles, California. Marshall, which serves grades 9 through 12, is a part of the Los Angeles Unified School District. Marshall is named after jurist John Marshall, who served as the fourth Chief Justice of the United States for three decades. Students at Marshall primarily come from Los Feliz, Atwater Village, East Hollywood, northeastern Koreatown, Elysian Valley, and Silver Lake. Within the school, there are many Small Learning Communities, including the School for Environmental Studies, the school's only California Partnership Academy, the Performing Arts Academy, the Artistic Vision Academy, the STARS Academy, the Renaissance Academy, and the Social Justice Academy. The School also houses a School for Advanced Studies and a Gifted/High Ability Magnet. History Designed by architect George M. Lindsey in the Collegiate Gothic style, and c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bispecific Monoclonal Antibody
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. Naturally occurring antibodies typically only target one antigen. BsAbs can be manufactured in several structural formats. BsAbs can be designed to recruit and activate immune cells, to interfere with receptor signaling and inactivate signaling ligands, and to force association of protein complexes. BsAbs have been explored for cancer immunotherapy, drug delivery, and Alzeimer's disease. Development history The original concept of BsAbs was proposed by Nisonoff and his collaborators in the 1960s, including the first idea of antibody architecture and other findings. In 1975, the problem of producing pure antibodies was solved by the creation of hybridoma technology, and the new era of monoclonal antibodies (MoAbs) came. In 1983, Milstein and Cuello created hybrid-hybridoma ( quadroma) technology. In 198 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GlaxoSmithKline
GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham. GSK is the tenth largest pharmaceutical company and #294 on the 2022 ''Fortune'' Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck. The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. , it had a market capitalisation of £70 billion, the eighth largest on the London Stock Exchange. It has a secondary listing on the New York Stock Exchange. The company developed the first malaria vaccine, RTS,S, which it said in 2014 it would make available for five percent above cost. Legacy products developed at GSK include several listed in the World Health Organization's List of Essential Medicines, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cabotegravir
Cabotegravir, sold under the brand name Vocabria among others, is a antiretroviral medication used for the treatment of HIV/AIDS. It is available in the form of tablets and as an intramuscular injection, as well as in an injectable Cabotegravir/rilpivirine, combination with rilpivirine under the brand name Cabenuva. It is an integrase inhibitor with a carbamoyl 2-Pyridone, pyridone structure similar to that of dolutegravir. In December 2021, the U.S. Food and Drug Administration approved cabotegravir for pre-exposure prophylaxis (PrEP) in at-risk people under the brand name Apretude. Medical uses Cabotegravir in combination with rilpivirine is indicated for the treatment of human immunodeficiency virus type-1 (HIV-1) in adults. The combination injection is intended for maintenance treatment of adults who have undetectable HIV levels in the blood (viral load less than 50 copies/mL) with their current antiretroviral treatment, and when the virus has not developed resistance to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhesus Macaques
The rhesus macaque (''Macaca mulatta''), colloquially rhesus monkey, is a species of Old World monkey. There are between six and nine recognised subspecies that are split between two groups, the Chinese-derived and the Indian-derived. Generally brown or grey in colour, it is in length with a tail and weighs . It is native to South, Central, and Southeast Asia and has the widest geographic range of all non-human primates, occupying a great diversity of altitudes and a great variety of habitats, from grasslands to arid and forested areas, but also close to human settlements. Feral colonies are found in the United States, thought to be either released by humans or escapees after hurricanes destroyed zoo and wildlife park facilities. The rhesus macaque is diurnal, arboreal, and terrestrial. It is mostly herbivorous, mainly eating fruit, but will also consume seeds, roots, buds, bark, and cereals. Studies show almost 100 different plant species in its diet. Rhesus macaques are gener ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virology
Virology is the Scientific method, scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host (biology), host cell (biology), cells for reproduction, their interaction with host organism physiology and immunity, the diseases they cause, the techniques to isolate and culture them, and their use in research and therapy. The identification of the causative agent of tobacco mosaic disease (TMV) as a novel pathogen by Martinus Beijerinck (1898) is now acknowledged as being the history of virology, official beginning of the field of virology as a discipline distinct from bacteriology. He realized the source was neither a bacterial nor a fungal infection, but something completely different. Beijerinck used the word "virus" to describe the mysterious agent in his 'contagium vivum fluidum' ('contagious living fluid'). Rosalind Franklin proposed the f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pandemic
A pandemic () is an epidemic of an infectious disease that has spread across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. A widespread endemic (epidemiology), endemic disease with a stable number of infected individuals is not a pandemic. Widespread endemic diseases with a stable number of infected individuals such as recurrences of seasonal influenza are generally excluded as they occur simultaneously in large regions of the globe rather than being spread worldwide. Throughout human history, there have been a number of pandemics of diseases such as smallpox. The most fatal pandemic in recorded history was the Black Death—also known as Plague (disease), The Plague—which killed an estimated 75–200 million people in the 14th century. The term had not been used then but was used for later epidemics, including the 1918 influenza pandemic—more commonly known as the Spanish flu. Current pandemics include Epide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cedars-Sinai Medical Center
Cedars-Sinai Medical Center is a nonprofit, tertiary, 886-bed teaching hospital and multi-specialty academic health science center located in Los Angeles, California. Part of the Cedars-Sinai Health System, the hospital employs a staff of over 2,000 physicians and 10,000 employees, supported by a team of 2,000 volunteers and more than 40 community groups. As of 2022-23, '' U.S. News & World Report'' ranked Cedars-Sinai the best hospital in the western United States. It ranked as the best hospital in California and 2nd best hospital in the entire United States; and was placed nationally in 11 adult medical specialties and rated high performing in 21 adult specialties, procedures and conditions. Cedars-Sinai is a teaching hospital affiliate of David Geffen School of Medicine at the University of California, Los Angeles (UCLA), which was ranked # 19 on the U.S. News 2023 Best Medical Schools: Research. Cedars-Sinai focuses on biomedical research and technologically advanced medical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts General Hospital
Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United States and has a capacity of 999 beds. With Brigham and Women's Hospital, it is one of the two founding members of Mass General Brigham (formerly known as Partners HealthCare), the largest healthcare provider in Massachusetts. Massachusetts General Hospital houses the largest hospital-based research program in the world, the Mass General Research Institute, with an annual research budget of more than $1 billion in 2019. It is currently ranked as the #8 best hospital in the United States by '' U.S. News & World Report''. In , ''The Boston Globe'' ranked MGH the fifth best place to work out of Massachusetts companies with over 1,000 employees. History Founded in 1811, the original hospital was designed by the famous American architect Char ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UCLA School Of Medicine
The University of California, Los Angeles School of Medicine—known as the David Geffen School of Medicine at UCLA (DGSOM)—is an accredited medical school located in Los Angeles, California, United States. The school was renamed in 2001 in honor of media mogul David Geffen who donated $200 million in unrestricted funds. Founded in 1951, it is the second medical school in the University of California system, after the UCSF School of Medicine. History Founding For many years, dating back to when it first affiliated with the University of California in 1873, the UCSF School of Medicine was the only public medical school in California. This made sense in the late 19th century when most of California's population lived in Northern California and Southern California was a lightly populated desert. It no longer made sense by the 1940s, after Los Angeles had overtaken San Francisco to become the leading metropolis on the West Coast of the United States. Dr.Elmer Belt was instru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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