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Dapivirine
Dapivirine is a non-nucleoside reverse transcriptase inhibitor developed at Janssen Therapeutics (formerly Tibotec Therapeutics). The International Partnership for Microbicides has held exclusive worldwide rights to dapivirine since 2014, building upon a 2004 royalty-free license to develop dapivirine-based microbicides for women in resource-poor countries. A monthly intravaginal ring containing dapivirine has been developed as a way of preventing infection by human immunodeficiency virus in women. Two phase 3 clinical trials of intravaginal dapivirine rings for HIV prevention were completed in 2015 and results were announced at the 2016 Conference on Retroviruses and Opportunistic Infections The Conference on Retroviruses and Opportunistic Infections (CROI) is an annual scientific meeting devoted to the understanding, prevention and treatment of HIV/AIDS and the opportunistic infection An opportunistic infection is an infection ca .... The ASPIRE Study (MTN-020) reported ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dapivirine Ring
Dapivirine (DPV) Ring is an antiretroviral vaginal ring pioneered by the International Partnership for Microbicides (IPM) pending for regulatory review. It is designed as a long-acting form of Prevention of HIV/AIDS, HIV prevention for at-risk women, particularly in Developing country, developing nations such as sub-Saharan Africa. IPM has rights to both the medication and the medical device. A total of four rings with different drug Modified-release dosage, diffusion systems and polymer composition have been developed by IPM. The latest design, Ring-004, is a Silicone elastomer, silicone polymer Modified-release dosage, matrix-type system capable of delivering DPV intravaginally in a Sustained release, sustained manner. From 2009 to 2012, two Phase I study, Phase I and one Phase I/II safety trials of the DPV ring were conducted by IPM. Results deemed the device to be well-tolerated and safe. In 2012, two Phase III clinical trials, Phase III studies were sequentially launched–– ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reverse-transcriptase Inhibitor
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs Enzyme inhibition, inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses. Mechanism of action When HIV infects a cell, reverse transcriptase copies the viral single stranded RNA genome into a double-stranded viral DNA. The viral DNA is then integrated into the host chromosomal DNA, which then allows host cellular processes, such as transcription and translation, to reproduce the virus. RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA, thus preventing HIV from multiplying. A similar process occurs with other types of viruses. The hepatitis B virus, for example, carries its genetic material in the form of DNA, and employs an RNA-dependent DNA polymerase to replicate. Some of the same compou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tibotec
Tibotec was a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV/AIDS and hepatitis C. The company was founded in 1994 and then acquired by Johnson & Johnson and merged into its Janssen Pharmaceuticals division in 2002. History In 1994, Rudi Pauwels of the Rega Institute for Medical Research founded Tibotec, together with his wife Carine Claeys, and their first co-workers Marie-Pierre de Béthune, Kurt Hertogs, and Hilde Azijn. In 1995 Paul Stoffels (Janssen Pharmaceuticals) joined Tibotec. The company was acquired by Johnson & Johnson in April 2002. The name of the company is derived from the ''tetrahydro-imidazo ,5,1-jk1,4]-benzodiazepine-2(1H)-one and -thione'' (TIBO) compounds discovered at the Rega Institute for Medical Research (Belgium). Drugs * Darunavir (TMC114, tradename Prezista), a protease inhibitor * Etravirine (TMC125, tradename Intelence), a non-nucleoside reverse transcriptase inhibitor (NNRTI) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Partnership For Microbicides
The International Partnership for Microbicides or IPM is a non-profit product development partnership (PDP) founded by Dr. Zeda Rosenberg in 2002 to prevent HIV transmission by accelerating the development and availability of a safe and effective microbicide for use by women in developing countries. Since its inception, IPM has focused on developing HIV-prevention products for women including gels, films, tablets and rings that contain antiretroviral (ARV)-based microbicides. Rights to incorporate existing ARVs into products developed specifically for use in developing countries have been negotiated with pharmaceutical companies working in the HIV field. See also * International AIDS Society * Joint United Nations Programme on HIV/AIDS (UNAIDS) * Prince Leopold Institute of Tropical Medicine * Tibotec Tibotec was a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV/AIDS and hepatitis C. The company was founded in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intravaginal Administration
Intravaginal administration is a route of administration where the substance is applied inside the vagina. Pharmacologically, it has the potential advantage to result in effects primarily in the vagina or nearby structures (such as the vaginal portion of cervix) with limited systemic adverse effects compared to other routes of administration. Formulation methods include vaginal tablets, vaginal cream, vaginal gel, vaginal suppository and vaginal ring. Medicines primarily delivered by intravaginal administration include vaginally administered estrogens and progestogens (a group of hormones including progesterone), and antibacterials and antifungals to treat bacterial vaginosis and yeast infections respectively. Medicines may also be administered intravaginally as an alternative to oral route in the case of nausea or other digestive problems. It is a potential means of artificial insemination Artificial insemination is the deliberate introduction of sperm into a female's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conference On Retroviruses And Opportunistic Infections
The Conference on Retroviruses and Opportunistic Infections (CROI) is an annual scientific meeting devoted to the understanding, prevention and treatment of HIV/AIDS and the opportunistic infection An opportunistic infection is an infection caused by pathogens (bacteria, fungi, parasites or viruses) that take advantage of an opportunity not normally available. These opportunities can stem from a variety of sources, such as a weakened immune ...s associated with AIDS. Thousands of leading researchers and clinicians from around the world convene in a different location in North America each year for the Conference. List of conferences Below is the list of conferences and their venue: External links * {{Official website, http://www.croiconference.org/ Webcasts of past conferencesConference Manager, IAS-USA International AIDS Conferences Recurring events established in 1993 Annual events in the United States ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-nucleoside Reverse Transcriptase Inhibitors
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses. Mechanism of action When HIV infects a cell, reverse transcriptase copies the viral single stranded RNA genome into a double-stranded viral DNA. The viral DNA is then integrated into the host chromosomal DNA, which then allows host cellular processes, such as transcription and translation, to reproduce the virus. RTIs block reverse transcriptase's enzymatic function and prevent completion of synthesis of the double-stranded viral DNA, thus preventing HIV from multiplying. A similar process occurs with other types of viruses. The hepatitis B virus, for example, carries its genetic material in the form of DNA, and employs an RNA-dependent DNA polymerase to replicate. Some of the same compounds used as RTIs c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
