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Duboisia Leichhardtii
:''The orchid genus described by Karsten as ''Duboisia'' is now included in '' Myoxanthus. For the prehistoric antelope genus, see '' Duboisia (antelope).'' ''Duboisia'' (commonly called corkwood tree) is a genus of small perennial shrubs and trees that grow up to 14 metres (46 feet) tall, with extremely light wood and a thick corky bark. There are four species; all occur in Australia, and one also occurs in New Caledonia. The alternate, glabrous leaves are narrow and elliptical. The inflorescence is an open cymose panicle of apically small white flowers, sometimes with a purple or mauve striped tube. They flower profusely in spring. The fruit is a small, globular, black, juicy berry. Aboriginal Australians sometimes chew the nicotine-containing leaves of ''Duboisia hopwoodii'' (see entry on '' pituri'') mixed with wood ash for their stimulant and, after extended use, depressant effects. The leaves of '' Duboisia leichhardtii'' and '' Duboisia myoporoides'' also contain s ...
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Gustav Karl Wilhelm Hermann Karsten
Gustav Karl Wilhelm Hermann Karsten (6 November 1817, in Stralsund – 10 July 1908, in Zoppot) was a German botanist and geologist. Born in Stralsund, he followed the example of Alexander von Humboldt and traveled 1844-56 the northern part of South America (Venezuela, Ecuador and Colombia). From 1856 to 1868, he was a professor at the agricultural college in Berlin, afterwards serving as a professor of plant physiology at the University of Vienna (1868–72). In 1881, at the suggestion of David Friedrich Weinland, Karsten became convinced of the correctness of Otto Hahn's organic theory of the chondrites and, as a result, wrote an essay entitled "Die Meteorite und ihre Organismen" in which he declared his support for Hahn's theory. He died 1908 in Berlin-Grunewald. As a taxonomist In biology, taxonomy () is the scientific study of naming, defining ( circumscribing) and classifying groups of biological organisms based on shared characteristics. Organisms are grouped i ...
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Inflorescence
An inflorescence is a group or cluster of flowers arranged on a stem that is composed of a main branch or a complicated arrangement of branches. Morphologically, it is the modified part of the shoot of seed plants where flowers are formed on the axis of a plant. The modifications can involve the length and the nature of the internodes and the phyllotaxis, as well as variations in the proportions, compressions, swellings, adnations, connations and reduction of main and secondary axes. One can also define an inflorescence as the reproductive portion of a plant that bears a cluster of flowers in a specific pattern. The stem holding the whole inflorescence is called a peduncle. The major axis (incorrectly referred to as the main stem) above the peduncle bearing the flowers or secondary branches is called the rachis. The stalk of each flower in the inflorescence is called a pedicel. A flower that is not part of an inflorescence is called a solitary flower and its stalk is al ...
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Nicotianoideae
Nicotianoideae is a subfamily within the family ''Solanaceae''. Most genera are found in Australia, but they are also found in America and Africa. The subfamily contains eight genera and about 125 species, 90 of them are included in ''Nicotiana''. Genera: '' Anthocercis'' ''Anthotroche'' ''Crenidium'' ''Cyphanthera'' ''Duboisia'' '' Grammosolen'' ''Nicotiana ''Nicotiana'' () is a genus of herbaceous plants and shrubs in the Family (biology), family Solanaceae, that is Native plant, indigenous to the Americas, Australia, Southwestern Africa and the South Pacific. Various ''Nicotiana'' species, common ...'' '' Symonanthus'' References {{Taxonbar, from=Q2852751 Asterid subfamilies ...
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Pharmaceutical Industry
The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy using drug testing and marketing of drugs. The global pharmaceuticals market produced treatments worth $1,228.45 billion in 2020 and showed a compound annual growth rate (CAGR) of 1.8%. History Mid-1800s – 1945: From botanicals to the first synthetic drugs The modern era of pharmaceutical industry began with local apothecaries that expanded from their traditional role of distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mid-1800s, and from discoveries resulting from applied research. Intentional drug ...
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Antispasmodic
An antispasmodic (synonym: spasmolytic) is a pharmaceutical drug or other agent that suppresses muscle spasms. Smooth muscle spasm One type of antispasmodics is used for smooth muscle relaxation, especially in tubular organs of the gastrointestinal tract. The effect is to prevent spasms of the stomach, intestine or urinary bladder. Both dicyclomine and hyoscyamine are antispasmodic due to their anticholinergic action. Both of these drugs have general side effects and can worsen gastroesophageal reflux disease. Mebeverine is a musculotropic spasmolytic with a strong and selective action on the smooth muscle spasm of the gastrointestinal tract, particularly of the colon. It does not have the acetylcholine side effect commonly seen in an anticholinergic antispasmodic. Papaverine is an opium alkaloid used to treat visceral spasms, erectile dysfunction and investigated as antipsychotic drug due to its potency to inhibit phosphodiesterase PDE10A. Peppermint oil has been traditio ...
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Butylscopolamine
Hyoscine butylbromide, also known as scopolamine butylbromide and sold under the brandname Buscopan among others, is an anticholinergic medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. It is also used to improve respiratory secretions at the end of life. Hyoscine butylbromide can be taken by mouth, injection into a muscle, or into a vein. Side effects may include sleepiness, vision changes, dry mouth, rapid heart rate, triggering of glaucoma, and severe allergies. Sleepiness is uncommon. It is unclear if it is safe in pregnancy. It appears safe in breastfeeding. Greater care is recommended in those with heart problems. It is an anticholinergic agent, which does not have much effect on the brain. Hyoscine butylbromide was patented in 1950, and approved for medical use in 1951. It is on the World Health Organization's List of Essential Medicines. It is not available in the United States, and a similar compound methscopola ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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Hyoscyamine
Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae, including henbane, mandrake, angel's trumpets, jimsonweed, tomato, the sorcerers' tree, and deadly nightshade. It is the levorotary isomer of atropine (third of the three major nightshade alkaloids) and thus sometimes known as levo-atropine. Brand names for hyoscyamine include Symax, HyoMax, Anaspaz, Egazil, Buwecon, Cystospaz, Levsin, Levbid, Levsinex, Donnamar, NuLev, Spacol T/S, and Neoquess. Uses Hyoscyamine is used to provide symptomatic relief of spasms caused by various lower abdominal and bladder disorders including peptic ulcers, irritable bowel syndrome, diverticulitis, pancreatitis, colic, and interstitial cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of abnormal respiratory symptoms and " ...
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Scopolamine
Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is formally used as a medication for treating motion sickness and postoperative nausea and vomiting. It is also sometimes used before surgery to decrease saliva. When used by injection, effects begin after about 20 minutes and last for up to 8 hours. It may also be used orally and as a transdermal patch since it has been long known to have transdermal bioavailability Scopolamine is in the antimuscarinic family of drugs and works by blocking some of the effects of acetylcholine within the nervous system. Scopolamine was first written about in 1881 and started to be used for anesthesia around 1900. Scopolamine is also the main active component produced by certain plants of the nightshade family, which historically have been used as psychoactive drugs (known as ''deliriants'') due to their antimuscarinic-induced hallucinogenic eff ...
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Stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have Sympathomimetic drug, sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or Prohibition (drugs), illicitly) as performance-enhancing substance, performance-enhancing or recreational drug use, recreational drugs. Among narcotics, stimulants produce a noticeable crash or ''Comedown (drugs), comedown'' at the end of their effects. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine (Vyvanse), methylphenidate (Ritalin), and amphetamine (Adderall). It was estimated in 2015 that the percentage of the world population that had used cocaine during a year was 0.4%. For the category "amphetamines and p ...
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Pituri
Pituri, also known as mingkulpa, is a mixture of leaves and wood ash traditionally chewed as a stimulant (or, after extended use, a depressant) by Aboriginal Australians widely across the continent. Leaves are gathered from any of several species of native tobacco (''Nicotiana'') or from at least one distinct population of the species ''Duboisia hopwoodii''. Various species of ''Acacia'', ''Grevillea'' and ''Eucalyptus'' are burned to produce the ash. The term "pituri" may also refer to the plants from which the leaves are gathered or from which the ash is made. Some authors use the term to refer only to the plant ''Duboisia hopwoodii'' and its leaves and any chewing mixture containing its leaves.Silcock JL, Tischler M, Smith MA"Quantifying the Mulligan River Pituri, ''Duboisia hopwoodii'' ((F.Muell.) F.Muell.) (Solanaceae), Trade of Central Australia."''Ethnobotany Research & Applications''. 2012; 10:037-044. Retrieved 30 April 2015. History The earliest record of Aboriginal ch ...
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Nicotine
Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and ''Duboisia hopwoodii'') and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist. Nicotine constitutes approximately 0.6–3.0% of the dry weight of tobacco. Nicotine is also present at ppb-concentrations in edible plants in the family Solanaceae, including potatoes, tomatoes, and eggplants, though sources disagree on whether this has any biological significance to human consumers. It functions as an antiherbivore toxin; consequently, nicotine was widely used as an insecticide in the past, and neonicotinoids (structurally similar to nicotine), such as imidacloprid, are s ...
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