Douglas Moray Cooper Lamb Argyll Robertson
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Douglas Moray Cooper Lamb Argyll Robertson
Douglas Moray Cooper Lamb Argyll Robertson FRSE, FRCSEd LLD (1837 – 3 January 1909) was a Scottish ophthalmologist and surgeon. He introduced physostigmine into ophthalmic practice and the Argyll Robertson pupil is named after him. He was president of the Royal College of Surgeons of Edinburgh. Early life He was born at 58 Queen Street in Edinburgh in 1837, the son of Dr John Argyll Robertson, a surgeon with an interest in surgery of the eye who had served as President of the Royal College of Surgeons of Edinburgh in 1846. His older brother, C. Lockhart Robertson was an eminent psychiatrist and Lord Chancellor's medical visitor. Argyll Robertson was educated at the Edinburgh Institution and at Neuwied in Germany going on to study medicine at the Universities of Edinburgh and St Andrews.MacKay, G. Obituary Douglas Argyll Robertson. ''Caledonian Medical Journal''1909;7:448-454 Career After graduating MD in 1857 from the University of St Andrews, he was appointed house sur ...
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Douglas Argyll Robertson
Douglas Moray Cooper Lamb Argyll Robertson FRSE, FRCSEd LLD (1837 – 3 January 1909) was a Scottish ophthalmologist and surgeon. He introduced physostigmine into ophthalmic practice and the Argyll Robertson pupil is named after him. He was president of the Royal College of Surgeons of Edinburgh. Early life He was born at 58 Queen Street in Edinburgh in 1837, the son of Dr John Argyll Robertson, a surgeon with an interest in surgery of the eye who had served as President of the Royal College of Surgeons of Edinburgh in 1846. His older brother, C. Lockhart Robertson was an eminent psychiatrist and Lord Chancellor's medical visitor. Argyll Robertson was educated at the Edinburgh Institution and at Neuwied in Germany going on to study medicine at the Universities of Edinburgh and St Andrews.MacKay, G. Obituary Douglas Argyll Robertson. ''Caledonian Medical Journal''1909;7:448-454 Career After graduating MD in 1857 from the University of St Andrews, he was appointed house surg ...
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Albrecht Von Graefe (ophthalmologist)
Friedrich Wilhelm Ernst Albrecht von Gräfe, often Anglicized to Graefe (22 May 182820 July 1870), was a Prussian pioneer of German ophthalmology. Graefe was born in Finkenheerd, Brandenburg, the son of Karl Ferdinand von Graefe (1787–1840). He was the father of the far right politician Albrecht von Graefe (1868–1933). Background At the University of Berlin, Graefe studied philosophy, logic, natural sciences and anatomy, under notable names such as Dove, H. Rose, Müller, and Schlemm, eventually obtaining his medical doctorate in 1847. He continued his studies at Prague, Paris, Vienna and London, and having devoted special attention to ophthalmology, in 1850, he began to practice as an oculist in Berlin. Here, he founded a private institution for the treatment of eyes. During the same year, he received his habilitation with the thesis ''Über die Wirkung der Augenmuskeln''. In 1858 he became an associate professor of ophthalmology at the Charité in Berlin, where in 18 ...
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Tabes Dorsalis
Tabes dorsalis is a late consequence of neurosyphilis, characterized by the slow degeneration (specifically, demyelination) of the neural tracts primarily in the dorsal root ganglia of the spinal cord (nerve root). These patients have lancinating nerve root pain which is aggravated by coughing, and features of sensory ataxia with ocular involvement. Signs and symptoms Signs and symptoms may not appear for decades after the initial infection and include weakness, diminished reflexes, paresthesias (shooting and burning pains, pricking sensations, and formication), hypoesthesias (abnormally diminished sense of touch), tabetic gait (locomotor ataxia), progressive degeneration of the joints, loss of coordination, episodes of intense pain and disturbed sensation (including glossodynia), personality changes, urinary incontinence, dementia, deafness, visual impairment, positive Romberg's test, and impaired response to light (Argyll Robertson pupil). The skeletal musculature is hypotonic d ...
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Neurosyphilis
Neurosyphilis refers to infection of the central nervous system in a patient with syphilis. In the era of modern antibiotics the majority of neurosyphilis cases have been reported in HIV-infected patients. Meningitis is the most common neurological presentation in early syphilis. Tertiary syphilis symptoms are exclusively neurosyphilis, though neurosyphilis may occur at any stage of infection. To diagnose neurosyphilis, patients undergo a lumbar puncture to obtain cerebrospinal fluid (CSF) for analysis. The CSF is tested for antibodies for specific ''Treponema pallidum'' antigens. The preferred test is the VDRL test, which is sometimes supplemented by fluorescent treponemal antibody absorption test (FTA-ABS). Historically, the disease was studied under the Tuskegee study, a notable example of unethical human experimentation. The study was done on approximately 400 African-American men with untreated syphilis who were followed from 1932 to 1972 and compared to approximately 200 me ...
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Ludwig Laqueur
Ludwig Laqueur (July 25, 1839 – April 20, 1909) was a German ophthalmologist born in Twardogóra, Festenberg, Silesia. He was the father of historian Richard Laqueur (1881–1959). He studied medicine in Breslau and Berlin, earning his doctorate in 1860. From 1863 to 1869 he worked as an assistant at Richard Liebreich's ophthalmological hospital in Paris. In 1872 he became an associate professor at the University of Strasbourg, where in 1877 he was appointed a full professor of ophthalmology. Among his assistants at Strasbourg was Paul Silex (1858-1929). Laqueur is remembered for his research of physostigmine, a chemical substance found in the Calabar bean (''Physostigma venenosa'') of West Africa. In 1876 he published ''Ueber eine neue therapeutische Verwendung des Physostigmin'', suggesting the use of physostigmine for the treatment of glaucoma . Laqueur noticed that extracts of the Calabar bean significantly lowered intraocular pressure. He could attest to these results firs ...
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Miotic
Miosis, or myosis (), is excessive constriction of the pupil.Farlex medical dictionary
citing: Mosby's Medical Dictionary, 8th ed. The opposite condition, , is the dilation of the pupil. is the condition of one being more dilated than the other.


Causes


Age

* Senile miosis (a reduction in the size of a person's pupil in old age) ...
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Thomas Richard Fraser
Sir Thomas Richard Fraser (5 February 1841 – 4 January 1920) was a British physician and pharmacologist. Together with Alexander Crum Brown he discovered the relationship between physiological activity and chemical constitution of the body. Life He was born in Calcutta in India on 5 February 1841, the second son of Mary Palmer and John Richard Fraser, Indian civil servant. Fraser attended the University of Edinburgh Medical School and graduated with an MD and gold medal in 1862. His award-winning thesis was based on the positive medical applications of physostigmine. This had been discovered by Sir Robert Christison in 1846 but its suggested uses were largely as a humane killing mechanism rather than as a medical tool.https://www.rcpe.ac.uk/sites/default/files/notable_fellow.pdf In 1869, Fraser was a medical assistant professor at the Edinburgh Royal Infirmary. In 1877, he was a member of an Arctic expedition and later in 1877 was appointed professor of medicine at the U ...
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Robert Christison
Sir Robert Christison, 1st Baronet, (18 July 1797 – 27 January 1882) was a Scottish toxicologist and physician who served as president of the Royal College of Physicians of Edinburgh (1838–40 and 1846-8) and as president of the British Medical Association (1875). He was the first person to describe renal anaemia. Life Christison was born at 144 Nicolson Street in Edinburgh, the son of Margaret Johnstone and Alexander Christison FRSE (1753–1820). He was a twin, his elder brother (by a few minutes) being later Rev. Alexander Christison (1797–1874). He attended the Royal High School before studying medicine at University of Edinburgh, graduating in 1819. At this time the family were living at 4 Argyll Square. He then spent a short time in London, studying under John Abernethy and Sir William Lawrence, and in Paris, where he learned analytical chemistry from Pierre Robiquet and toxicology from Mathieu Orfila. In 1822 he returned to Edinburgh as professor of medical ...
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Calabar Bean
''Physostigma venenosum'', the Calabar bean or ordeal bean, is a leguminous plant, Endemic to tropical Africa, with a seed poisonous to humans. It derives the first part of its scientific name from a curious beak-like appendage at the end of the stigma, in the centre of the flower; this appendage, though solid, was supposed to be hollow (hence the name from , a bladder, and stigma). Growth The plant is a large, herbaceous, climbing perennial, with the stem woody at the base, up to in diameter; it has a habit like the scarlet runner, and attains a height of about . The flowers, appearing in axillary peduncles, are large, about long, grouped in pendulous, fascicled racemes pale-pink or purplish, and heavily veined. The seed pods, which contain two or three seeds or beans, are in length; and the beans are about the size of an ordinary horse bean but less flattened, with a deep chocolate-brown color. Toxicology Calabar bean contains physostigmine, a reversible cholinesterase i ...
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William Walker (surgeon)
William Walker (6 November 1813 – 16 August 1885) was a Scottish surgeon who specialised in ophthalmic surgery. He was Surgeon Oculist in Scotland to Queen Victoria and President of the Royal College of Surgeons of Edinburgh. He was a keen amateur photographer, whose calotypes were displayed in photography exhibitions. Early life William Walker was born on 6 November 1813 in Dumfries, son of Margaret Walker (née Burnside) and William Walker, a Dumfries merchant. His mother was the daughter of Reverend William Burnside DD (1751–1806), minister of St Michael's Church, Dumfries and a friend of the poet Robert Burns. His father William Walker of Kelton Mains, Dumfriesshire, who had been a West Indies trader, died in November 1820 when his son was 7 years old. When his schooling was completed in Dumfries, his mother took the family to Edinburgh where they lived at first at 54 Northumberland Street in the New Town. Career He studied medicine in Edinburgh, taking the Licentiate ...
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Edinburgh Royal Infirmary
The Royal Infirmary of Edinburgh, or RIE, often (but incorrectly) known as the Edinburgh Royal Infirmary, or ERI, was established in 1729 and is the oldest voluntary hospital in Scotland. The new buildings of 1879 were claimed to be the largest voluntary hospital in the United Kingdom, and later on, the Empire."In Coming Days" The Edinburgh Royal Infirmary Souvenir Brochure 1942 The hospital moved to a new 900 bed site in 2003 in Little France. It is the site of clinical medicine teaching as well as a teaching hospital for the University of Edinburgh Medical School. In 1960, the first successful kidney transplant performed in the UK was at this hospital. In 1964, the world's first coronary care unit was established at the hospital. It is the only site for liver, pancreas and pancreatic islet cell transplantation and one of two sites for kidney transplantation in Scotland. In 2012, the Emergency Department had 113,000 patient attendances, the highest number in Scotland. It is man ...
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Surgeons' Hall
Surgeons' Hall in Edinburgh, Scotland, is the headquarters of the Royal College of Surgeons of Edinburgh (RCSEd). It houses the Surgeons' Hall Museum, and the library and archive of the RCSEd. The present Surgeons' Hall was designed by William Henry Playfair and completed in 1832, and is a category A listed building. Surgeons' Hall Museum is the major medical museum in Scotland, and one of Edinburgh's many tourist attractions. The museum is recognised as a collection of national significance by the Scottish Government. The museum reopened in September 2015, after being closed for an eighteen-month period of redevelopment. History Origins The Royal College of Surgeons of Edinburgh was incorporated in 1505, when it received its Seal of Cause or charter and became styled as "The Incorporation of Surgeons and Barbers of Edinburgh". The Museum at Surgeons Hall, Edinburgh dates from 1699 when the Incorporation announced that they were making a collection of ‘natural and artific ...
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