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Donald Fredrickson
Donald Sharp "Don" Fredrickson (August 8, 1924 – June 7, 2002) was an American medical researcher, principally of the lipid and cholesterol metabolism, and director of National Institutes of Health and subsequently the Howard Hughes Medical Institute. Wyngaarden JB. "Donald Sharp Fredrickson". In ''Biographical Memoirs''. National Academy of Sciences 2006;87:164-179. Fulltext Reprinted from ''Proc Am Phil Soc'' 2004;148(3):382-393PDF. Biography Fredrickson was born in Cañon City, Colorado. His father was a county judge and the owner of Fredrickson Brown, an independent insurance agency. After high school he commenced medical school at the University of Colorado, but completed his studies at the University of Michigan after being transferred there by the army. During a cycling trip in the Netherlands he met his future wife, Priscilla Eekhof, and they married two years later. They had two sons. Between 1949 and 1952 he worked as a resident and subsequently as a fellow in i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Director Of The National Institutes Of Health
The director of the National Institutes of Health (NIH) plays an active role in shaping the agency's activities and outlook. The director is responsible for providing leadership to the institutes and for constantly identifying needs and opportunities, especially for efforts that involve multiple institutes. The NIH director is responsible for advising the U.S. president on their annual budget request to Congress on the basis of extensive discussions with the institute directors. History The position of the NIH Director became presidentially appointed with the passage of the National Cancer Act of 1971 and Senate confirmed with the National Cancer Act Amendments of 1974. Prior to 1971, all NIH Directors were appointed by the Surgeon General, with the exception of Robert Q. Marston, who was appointed by the Secretary of Health, Education, and Welfare. Acting Directors are selected by the Secretary of Health and Human Services and hold the position until the President nominates a n ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Colorado Health Sciences Center
The University of Colorado Anschutz Medical Campus is the academic health sciences campus in Aurora, Colorado that houses the University of Colorado's six health sciences-related schools and colleges, including the University of Colorado School of Medicine, the CU Skaggs School of Pharmacy and Pharmaceutical Sciences, the CU College of Nursing, the University of Colorado School of Dental Medicine, and the Colorado School of Public Health, as well as the graduate school for various fields in the biological and biomedical sciences. The campus also includes the Fitzsimons Innovation Community, UCHealth University of Colorado Hospital, Children's Hospital Colorado, the Rocky Mountain Regional Veterans Affairs hospital, and a residential/retail town center known as 21 Fitzsimons. The campus is located on a portion of the former Fitzsimons Army Medical Center. After the base was decommissioned in 1999, the campus became known as the Fitzsimons Medical Campus, or simply "Fitzsimons, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apolipoprotein
Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fats, cholesterol and fat soluble vitamins) to form lipoproteins. They transport lipids in blood, cerebrospinal fluid and lymph. The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through body fluids (i.e., blood, lymph). In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake and clearance. They also serve as enzyme cofactors for specific enzymes involved in the metabolism of lipoproteins. Apolipoproteins are also exploited by hepatitis C virus (HCV) to enable virus entry, assembly, and trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholesteryl Ester Storage Disease
Lysosomal acid lipase deficiency (LAL deficiency or LAL-D) is an autosomal recessive inborn error of metabolism that results in the body not producing enough active lysosomal acid lipase (LAL) enzyme. This enzyme plays an important role in breaking down fatty material (cholesteryl esters and triglycerides) in the body. Infants, children and adults that have LAL deficiency experience a range of serious health problems. The lack of the LAL enzyme can lead to a build-up of fatty material in a number of body organs including the liver, spleen, gut, in the wall of blood vessels and other important organs. Very low levels of the LAL enzyme lead to LAL deficiency. LAL deficiency typically affects infants in the first year of life. The accumulation of fat in the walls of the gut in early onset disease leads to serious digestive problems including malabsorption, a condition in which the gut fails to absorb nutrients and calories from food. Because of these digestive complications, affecte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tangier Disease
Tangier disease or hypoalphalipoproteinemia is an extremely rare inherited disorder characterized by a severe reduction in the amount of high density lipoprotein (HDL), often referred to as "good cholesterol", in the bloodstream. Worldwide, approximately 100 cases have even been identified. The disorder was originally discovered on Tangier Island off the coast of Virginia, but has now been identified in people from many different countries. Signs and symptoms Individuals that are homozygotes for Tangier's disease develop various cholesterol ester depositions. These are especially visible in the tonsils, as they may appear yellow/orange. The cholesterol esters may also be found in lymph nodes, bone marrow, the liver and spleen. Due to the cholesterol ester depositions the tonsils may be enlarged. Hepatosplenomegaly (enlarged liver and spleen) is common. Neuropathy and cardiovascular disease are the most devastating developments caused by Tangier's disease.Serfaty-Lacrosnier ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipoprotein
A lipoprotein is a biochemical assembly whose primary function is to transport hydrophobic lipid (also known as fat) molecules in water, as in blood plasma or other extracellular fluids. They consist of a triglyceride and cholesterol center, surrounded by a phospholipid outer shell, with the hydrophilic portions oriented outward toward the surrounding water and lipophilic portions oriented inward toward the lipid center. A special kind of protein, called apolipoprotein, is embedded in the outer shell, both stabilising the complex and giving it a functional identity that determines its role. Many enzymes, transporters, structural proteins, antigens, adhesins, and toxins are lipoproteins. Examples include plasma lipoprotein particles ( HDL, LDL, IDL, VLDL and chylomicrons). Subgroups of these plasma particles are primary drivers or modulators of atherosclerosis. Scope Transmembrane lipoproteins Some transmembrane proteolipids, especially those found in bacteria, are referred ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christian B
Christians () are people who follow or adhere to Christianity, a monotheistic Abrahamic religion based on the life and teachings of Jesus Christ. The words ''Christ'' and ''Christian'' derive from the Koine Greek title ''Christós'' (Χριστός), a translation of the Biblical Hebrew term ''mashiach'' (מָשִׁיחַ) (usually rendered as ''messiah'' in English). While there are diverse interpretations of Christianity which sometimes conflict, they are united in believing that Jesus has a unique significance. The term ''Christian'' used as an adjective is descriptive of anything associated with Christianity or Christian churches, or in a proverbial sense "all that is noble, and good, and Christ-like." It does not have a meaning of 'of Christ' or 'related or pertaining to Christ'. According to a 2011 Pew Research Center survey, there were 2.2 billion Christians around the world in 2010, up from about 600 million in 1910. Today, about 37% of all Christians live in the Amer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Heart Institute
The National Heart, Lung, and Blood Institute (NHLBI) is the third largest Institute of the National Institutes of Health, located in Bethesda, Maryland, United States. It is tasked with allocating about $3.6 billion in FY 2020 in tax revenue to advancing the understanding of the following issues: development and progression of disease, diagnosis of disease, treatment of disease, disease prevention, reduction of health care disparities within the American population, and advancing the effectiveness of the US medical system. NHLBI's Director is Gary H. Gibbons (2012–present). Operation In 1948, the National Heart Act established the National Heart Institute and the National Advisory Heart Council. The intramural research program was established a year later in 1949. In 1969, the National Heart Institute was renamed the National Heart and Lung Institute, and the scope of the institute was expanded. In 1976, it was given its current name, the National Heart, Lung, and Blood Insti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts General Hospital
Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United States and has a capacity of 999 beds. With Brigham and Women's Hospital, it is one of the two founding members of Mass General Brigham (formerly known as Partners HealthCare), the largest healthcare provider in Massachusetts. Massachusetts General Hospital houses the largest hospital-based research program in the world, the Mass General Research Institute, with an annual research budget of more than $1 billion in 2019. It is currently ranked as the #8 best hospital in the United States by '' U.S. News & World Report''. In , ''The Boston Globe'' ranked MGH the fifth best place to work out of Massachusetts companies with over 1,000 employees. History Founded in 1811, the original hospital was designed by the famous American architect Char ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ivan Frantz
Ivan () is a Slavic male given name, connected with the variant of the Greek name (English: John) from Hebrew meaning 'God is gracious'. It is associated worldwide with Slavic countries. The earliest person known to bear the name was Bulgarian tsar Ivan Vladislav. It is very popular in Russia, Ukraine, Croatia, Serbia, Bosnia and Herzegovina, Slovenia, Bulgaria, Belarus, North Macedonia, and Montenegro and has also become more popular in Romance-speaking countries since the 20th century. Etymology Ivan is the common Slavic Latin spelling, while Cyrillic spelling is two-fold: in Bulgarian, Russian, Macedonian, Serbian and Montenegrin it is Иван, while in Belarusian and Ukrainian it is Іван. The Old Church Slavonic (or Old Cyrillic) spelling is . It is the Slavic relative of the Latin name , corresponding to English ''John''. This Slavic version of the name originates from New Testament Greek (''Iōánnēs'') rather than from the Latin . The Greek name is in turn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endocrinology
Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Specializations include behavioral endocrinology and comparative endocrinology. The endocrine system consists of several glands, all in different parts of the body, that secrete hormones directly into the blood rather than into a duct system. Therefore, endocrine glands are regarded as ductless glands. Hormones have many different functions and modes of action; one hormone may have several effects on different target organs, and, conversely, one target orga ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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