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Dikinase
Dikinases are a category of enzymes that catalyze the chemical reaction :ATP + X + Y \rightleftharpoons AMP + X-''P'' + Y-''P''. Dikinases are all phosphotransferases. Their designated EC number is 2.7.9. It is one of the smallest groups of phosphotransferases. Function Dikinases take two phosphate groups from ATP and transfer each one to a different acceptor. This results in AMP and two different phosphorylated compounds. In most dikinases, one of the acceptors is water. In at least one dikinase ( pyruvate, phosphate dikinase), one of the acceptors is inorganic phosphate, resulting in diphosphate. For the dikinases that use water as acceptor, it has been shown that the ''γ''-phosphate of ATP (the third, most distant phosphate) is transferred to water, whereas the ''β''-phosphate (the middle phosphate) is transferred to the other acceptor. It has also been shown that the enzyme first phosphorylates itself (autophosphorylation). After transfer of the ''γ''-phosphate to wate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyruvate, Phosphate Dikinase
Pyruvate, phosphate dikinase, or PPDK () is an enzyme in the family of transferases that catalyzes the chemical reaction :ATP + pyruvate + phosphate \rightleftharpoons AMP + phosphoenolpyruvate + diphosphate This enzyme has been studied primarily in plants, but it has been studied in some bacteria as well. It is a key enzyme in gluconeogenesis and photosynthesis that is responsible for reversing the reaction performed by pyruvate kinase in Embden-Meyerhof-Parnas glycolysis. It should not be confused with pyruvate, water dikinase. It belongs to the family of transferases, to be specific, those transferring phosphorus-containing groups (phosphotransferases) with paired acceptors (dikinases). This enzyme participates in pyruvate metabolism and carbon fixation. Nomenclature The systematic name of this enzyme class is ATP:pyruvate, phosphate phosphotransferase. Other names in common use include pyruvate, orthophosphate dikinase, pyruvate-phosphate dikinase (phosphorylating), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
