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Deoxyschizandrin
Deoxyschizandrin is a bio-active isolate of ''Schisandra chinensis''. Deoxyschizandrin has been found to act as an agonist of the adiponectin receptor 2 Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ''ADIPOR2'' gene. It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2. Structure Similar to G protein-coupled receptors (GPCR ... (AdipoR2). References Adiponectin receptor agonists Phytochemicals {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adiponectin Receptor 2
Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ''ADIPOR2'' gene. It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2. Structure Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins. Function The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schisandra Chinensis
''Schisandra chinensis'' (common name: magnolia-vine, Chinese magnolia-vine, schisandra), whose fruit is called magnolia berry or five-flavor-fruit (from Chinese 五味子 ''wǔwèizi''), is a vine plant native to forests of Northern China, the Russian Far East and Korea. Wild varieties are also found in Japan. It is hardy in USDA Zone 4. The fruits are red berries in dense clusters around long. Etymology, common names, and taxonomy The genus ''Schisandra'' was first published by André Michaux in 1803, the name deriving from the Greek words ''schizein'' ('to split') and ''andros'' ('man'), referring to the separate anther cells on the stamens. In the 21st century, ''Schisandra chinensis'' belongs to the family of Schisandraceae. In earlier years, it was assumed that the species belonged to the family of Magnoliaceae, hence the name ''Chinese magnolia-vine''. However, many differences in plant phenology between Schisandra and members of Magnoliaceae led to the formatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology From the Greek αγωνιστής (agōnistēs), contestant; champion; rival < αγων (agōn), contest, combat; exertion, struggle < αγω (agō), I lead, lead towards, conduct; drive Types of agonists can be activated by either endogenous agonists (such as |
Adiponectin Receptor Agonists
Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels as well as fatty acid breakdown. In humans it is encoded by the ''ADIPOQ'' gene and it is produced in primarily in adipose tissue, but also in muscle, and even in the brain. Structure Adiponectin is a 244-amino-acid-long polypeptide (protein). There are four distinct regions of adiponectin. The first is a short signal sequence that targets the hormone for secretion outside the cell; next is a short region that varies between species; the third is a 65-amino acid region with similarity to collagenous proteins; the last is a globular domain. Overall this protein shows similarity to the complement 1Q factors (C1Q). However, when the 3-dimensional structure of the globular region was determined, a striking similarity to TNFα was observed, despite unrelated protein sequences. Function Adiponectin is a protein hormone that modulates ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
