Deoxyadenosine Triphosphate
Deoxyadenosine triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. It is classified as a purine nucleoside triphosphate, with its chemical structure consisting of a deoxyribose sugar molecule bound to an adenine and to three phosphate groups. It differs from the energy-transferring molecule adenosine triphosphate (ATP) by a single hydroxyl group (the -OH group on the 2' carbon of the pentose sugar is replaced by -H in dATP), resulting in a deoxyribose instead of a ribose. Two phosphate groups can be hydrolyzed to yield deoxyadenosine monophosphate, which can then be used to synthesize DNA. Findings have also suggested that dATP can act as an energy-transferring molecule to maintain cell viability. Synthesis Enzymatic synthesis of deoxyadenosine triphosphate Deoxyadenosine triphosphate is able to be enzymatically synthesized with DNA as the starting material using deoxyribonuclease (DNase), nuclease P1, aden ...
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