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David Sinclair (biologist)
David Andrew Sinclair (born June 26, 1969) is an Australian biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and is the co-director of its Paul F. Glenn Center for Biology of Aging Research. He is an officer of the Order of Australia (AO). Sinclair has appeared in ''Time'' magazine, ''The New York Times'', ''The Charlie Rose Show'', '' 60 Minutes'', ''Boston'' magazine, ''The Washington Post'', ''The Economist'', TED and ''The Joe Rogan Experience''. Early life and education David Andrew Sinclair was born in Australia in 1969, and he grew up in St Ives, New South Wales. His paternal grandmother had emigrated to Australia following the suppression of the Hungarian Uprising of 1956, and his father changed the family name from Szigeti to Sinclair. Sinclair studied at the University of New South Wales, Sydney, obtaining a BSc in biochemistry with honours in 1991 and a Ph.D. in molecular genetics i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sydney
Sydney ( ) is the capital city of the state of New South Wales, and the most populous city in both Australia and Oceania. Located on Australia's east coast, the metropolis surrounds Sydney Harbour and extends about towards the Blue Mountains to the west, Hawkesbury to the north, the Royal National Park to the south and Macarthur to the south-west. Sydney is made up of 658 suburbs, spread across 33 local government areas. Residents of the city are known as "Sydneysiders". The 2021 census recorded the population of Greater Sydney as 5,231,150, meaning the city is home to approximately 66% of the state's population. Estimated resident population, 30 June 2017. Nicknames of the city include the 'Emerald City' and the 'Harbour City'. Aboriginal Australians have inhabited the Greater Sydney region for at least 30,000 years, and Aboriginal engravings and cultural sites are common throughout Greater Sydney. The traditional custodians of the land on which modern Sydney stands are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Washington Post
''The Washington Post'' (also known as the ''Post'' and, informally, ''WaPo'') is an American daily newspaper published in Washington, D.C. It is the most widely circulated newspaper within the Washington metropolitan area and has a large national audience. Daily broadsheet editions are printed for D.C., Maryland, and Virginia. The ''Post'' was founded in 1877. In its early years, it went through several owners and struggled both financially and editorially. Financier Eugene Meyer purchased it out of bankruptcy in 1933 and revived its health and reputation, work continued by his successors Katharine and Phil Graham (Meyer's daughter and son-in-law), who bought out several rival publications. The ''Post'' 1971 printing of the Pentagon Papers helped spur opposition to the Vietnam War. Subsequently, in the best-known episode in the newspaper's history, reporters Bob Woodward and Carl Bernstein led the American press's investigation into what became known as the Watergate scandal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andrew Perlman
Andrew Perlman (born June 19, 1975) is an American entrepreneur who has co-founded nine venture-backed companies in the telecom, high-tech, pharmaceuticals, energy, water, and biotechnology industries. He is currently General Partner of GreatPoint Ventures,Bloomber ''Bloomberg'', May 14, 2015 and the former chairman and CEO of GreatPoint Energy, a company based in Chicago, Illinois which develops technology to produce clean natural gas from coal. Perlman has been featured on the MIT Technology Review’s list of the world's top 35 innovators under the age of 35"35 Innovators Under 35" ''MIT Technology Review'', 2009 and ’s list of 40 leade ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul F
Paul may refer to: *Paul (given name), a given name (includes a list of people with that name) *Paul (surname), a list of people People Christianity *Paul the Apostle (AD c.5–c.64/65), also known as Saul of Tarsus or Saint Paul, early Christian missionary and writer *Pope Paul (other), multiple Popes of the Roman Catholic Church *Saint Paul (other), multiple other people and locations named "Saint Paul" Roman and Byzantine empire *Lucius Aemilius Paullus Macedonicus (c. 229 BC – 160 BC), Roman general *Julius Paulus Prudentissimus (), Roman jurist *Paulus Catena (died 362), Roman notary *Paulus Alexandrinus (4th century), Hellenistic astrologer *Paul of Aegina or Paulus Aegineta (625–690), Greek surgeon Royals *Paul I of Russia (1754–1801), Tsar of Russia *Paul of Greece (1901–1964), King of Greece Other people *Paul the Deacon or Paulus Diaconus (c. 720 – c. 799), Italian Benedictine monk *Paul (father of Maurice), the father of Maurice, Byzan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis Elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (rod-like) and Latin ''elegans'' (elegant). In 1900, Maupas initially named it '' Rhabditides elegans.'' Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. ''C. elegans'' is an unsegmented pseudocoelomate and lacks respiratory or circulatory systems. Most of these nematodes are hermaphrodites and a few are males. Males have specialised tails for mating that include spicules. In 1963, Sydney Brenner proposed research into ''C. elegans,'' primarily in the area of neuronal development. In 1974, he began research into the molecular and developmental biology of ''C. elegans'', which has since been extensively used as a model organism. It was the first multicellu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daf-2
The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm ''Caenorhabditis elegans''. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproductive development, resistance to oxidative stress, thermotolerance, resistance to hypoxia, and resistance to bacterial pathogens. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms. In a 2007 episode of WNYC’s Radiolab, Kenyon called DAF-2 "the grim reaper gene.” Long-lived mutants Long-lived ''DAF-2'' ''C. elegans'' mutants are resistant to the oxidizing agent paraquat and to UV light. ''DAF-2'' mutants also have a higher DNA repair capability than wild-type ''C. elegans''. Knockdown of the nucleotide excision repair gene ''Xpa-1'' increases sensitivity to UV and reduces the life span of the long-lived mutants. These findings support the hypothesis that DNA damage has a significant role in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cynthia Kenyon
Cynthia Jane Kenyon (born February 21, 1954) is an American molecular biologist and biogerontologist known for her genetic dissection of aging in a widely used model organism, the roundworm ''Caenorhabditis elegans''. She is the vice president of aging research at Calico Research Labs, and emeritus professor of biochemistry and biophysics at the University of California, San Francisco (UCSF). Career Cynthia Kenyon graduated valedictorian in chemistry and biochemistry from the University of Georgia in 1976. She received her Ph.D. in 1981 from MIT where, in Graham Walker's laboratory, she looked for genes on the basis of their activity profiles, discovering that DNA-damaging agents activate a battery of DNA repair genes in E. coli. She then did postdoctoral studies with Nobel laureate Sydney Brenner at the MRC Laboratory of Molecular Biology in Cambridge, England, studying the development of ''C. elegans.'' Since 1986 she has been at the UCSF, where she was the Herbert Boyer Dis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Institute Of Technology
The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the most prestigious and highly ranked academic institutions in the world. Founded in response to the increasing industrialization of the United States, MIT adopted a European polytechnic university model and stressed laboratory instruction in applied science and engineering. MIT is one of three private land grant universities in the United States, the others being Cornell University and Tuskegee University. The institute has an urban campus that extends more than a mile (1.6 km) alongside the Charles River, and encompasses a number of major off-campus facilities such as the MIT Lincoln Laboratory, the Bates Center, and the Haystack Observatory, as well as affiliated laboratories such as the Broad and Whitehead Institutes. , 98 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leonard P
Leonard or ''Leo'' is a common English masculine given name and a surname. The given name and surname originate from the Old High German ''Leonhard'' containing the prefix ''levon'' ("lion") from the Greek Λέων ("lion") through the Latin '' Leo,'' and the suffix ''hardu'' ("brave" or "hardy"). The name has come to mean "lion strength", "lion-strong", or "lion-hearted". Leonard was the name of a Saint in the Middle Ages period, known as the patron saint of prisoners. Leonard is also an Irish origin surname, from the Gaelic ''O'Leannain'' also found as O'Leonard, but often was anglicised to just Leonard, consisting of the prefix ''O'' ("descendant of") and the suffix ''Leannan'' ("lover"). The oldest public records of the surname appear in 1272 in Huntingdonshire, England, and in 1479 in Ulm, Germany. Variations The name has variants in other languages: * Leen, Leendert, Lenard (Dutch) * Lehnertz, Lehnert (Luxembourgish) * Len (English) * :hu:Lénárd (Hungarian) * Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bachelor Of Science
A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University of London in 1860. In the United States, the Lawrence Scientific School first conferred the degree in 1851, followed by the University of Michigan in 1855. Nathaniel Southgate Shaler, who was Harvard's Dean of Sciences, wrote in a private letter that "the degree of Bachelor of Science came to be introduced into our system through the influence of Louis Agassiz, who had much to do in shaping the plans of this School." Whether Bachelor of Science or Bachelor of Arts degrees are awarded in particular subjects varies between universities. For example, an economics student may graduate as a Bachelor of Arts in one university but as a Bachelor of Science in another, and occasionally, both options are offered. Some universities follow the Oxford a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hungarian Uprising Of 1956
The Hungarian Revolution of 1956 (23 October – 10 November 1956; hu, 1956-os forradalom), also known as the Hungarian Uprising, was a countrywide revolution against the government of the Hungarian People's Republic (1949–1989) and the Hungarian domestic policies imposed by the Soviet Union (USSR). The Hungarian Revolution began on 23 October 1956 in Budapest when university students appealed to the civil populace to join them at the Hungarian Parliament Building to protest against the USSR's geopolitical domination of Hungary with the Stalinist government of Mátyás Rákosi. A delegation of students entered the building of Hungarian Radio to broadcast their sixteen demands for political and economic reforms to the civil society of Hungary, but they were instead detained by security guards. When the student protestors outside the radio building demanded the release of their delegation of students, policemen from the ÁVH ( Államvédelmi Hatóság) state protection autho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
St Ives, New South Wales
St Ives is a suburb on the Upper North Shore of Sydney in the state of New South Wales, Australia 18 kilometres north of the Sydney Central Business District in the local government area of Ku-ring-gai Council. St Ives Chase is a separate adjacent area, designated suburb, to the west and north. History The St Ives area was first explored by Governor Arthur Phillip and a party of men in 1788 where they set up a campsite at Bungaroo which is close to what is now Hunter Avenue. The area produced a small-scale timber felling industry. There are still some examples of the thirty-metre and higher trees in nearby Pymble in the Dalrymple-Hay Nature Reserve and near Canisius College. Native turpentine trees were also once abundant and provided useful timber for cabinet making. It was once known for its apple orchards, but due to residential demand, there is no longer any commercial fruit growing in the area. During the Second World War there were significant numbers of troops barrac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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