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David H. Gorski
David Henry Gorski is an American surgical oncologist, professor of surgery at Wayne State University School of Medicine, and a surgical oncologist at the Barbara Ann Karmanos Cancer Institute, specializing in breast cancer surgery. He is an outspoken "skeptic", and a critic of alternative medicine and the anti-vaccination movement. He is the author of the blog ''Respectful Insolence'', and the managing editor of the website '' Science-Based Medicine''. Early life and education Gorski attended the University of Michigan, where he received an MD in 1988. In 1989, he entered a residency in general surgery at the University Hospitals of Cleveland. He left residency for a PhD in cellular physiology at Case Western Reserve University, completed in 1994, with a dissertation entitled "Homeobox Gene Expression and Regulation in Vascular Myocytes." Gorski continued his residency (1993–96) and completed a surgical oncology research fellowship (1996–99) at The University of Chicag ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Case Western Reserve University
Case Western Reserve University (CWRU) is a private research university in Cleveland, Ohio. Case Western Reserve was established in 1967, when Western Reserve University, founded in 1826 and named for its location in the Connecticut Western Reserve, and Case Institute of Technology, founded in 1880 through the endowment of Leonard Case Jr., formally federated. Case Western Reserve University is a member of the Association of American Universities and is classified among "R1: Doctoral Universities – Very high research activity". According to the National Science Foundation, in 2019 the university had research and development (R&D) expenditures of $439 million, ranking it 20th among private institutions and 58th in the nation. The university has eight schools that offer more than 100 undergraduate programs and about 160 graduate and professional options. Seventeen Nobel laureates have been affiliated with Case Western Reserve's faculty and alumni or one of its two predecessors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surgical Oncology
Surgical oncology is the branch of surgery applied to oncology; it focuses on the surgical management of tumors, especially cancerous tumors. As one of several modalities in the management of cancer, the specialty of surgical oncology has evolved in steps similar to medical oncology (pharmacotherapy for cancer), which grew out of hematology, and radiation oncology, which grew out of radiology. The Ewing Society known today as the Society of Surgical Oncology was started by surgeons interested in promoting the field of oncology. Complex General Surgical Oncology was ratified by a specialty Board certification in 2011 from the American Board of Surgery. The proliferation of cancer centers will continue to popularize the field, as will developments in minimally invasive techniques, palliative surgery, and neo-adjuvant treatments. Debate Whether surgical oncology constitutes a medical specialty ''per se'' is the topic of a heated debate. Today, some would agree that it is simply impos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Research
Clinical research is a branch of healthcare science that determines the safety and effectiveness ( efficacy) of medications, devices, diagnostic products and treatment regimens intended for human use. These may be used for prevention, treatment, diagnosis or for relieving symptoms of a disease. Clinical research is different from clinical practice. In clinical practice established treatments are used, while in clinical research evidence is collected to establish a treatment. Overview The term "clinical research" refers to the entire bibliography of a drug/device/biologic, in fact any test article from its inception in the lab to its introduction to the consumer market and beyond. Once the promising candidate or the molecule is identified in the lab, it is subjected to pre-clinical studies or animal studies where different aspects of the test article (including its safety toxicity if applicable and efficacy, if possible at this early stage) are studied. In the United States ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Breast Cancer Research Foundation
The Breast Cancer Research Foundation (BCRF) is an independent, not-for-profit organization which has raised $569.4 million to support clinical and translational research on breast cancer at medical institutions in the United States and abroad. BCRF currently funds over 275 researchers in 15 countries. The BCRF's director of research is Dr. Larry Norton of Memorial Sloan-Kettering Cancer Center. BCRF has funded basic research on genetic susceptibility to breast cancer, breast cancer stem cells, trastuzumab (Herceptin), anti-angiogenesis treatment with bevacizumab (Avastin), MRI imaging, aromatase inhibitors, tamoxifen; and also clinical trials of new treatments with the Translational Breast Cancer Research Consortium. BCRF was founded in 1993 by Evelyn Lauder, Senior Corporate Vice President of The Estee Lauder Companies. Lauder's first foray into breast cancer awareness was through an initiative by herself and Alexandra Penney, former editor of ''SELF'' magazine, to make the pi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Society Of Clinical Oncology
The American Society of Clinical Oncology (ASCO) is a professional organization representing physicians of all oncology sub-specialties who care for people with cancer. Founded in 1964 by Fred Ansfield, Harry Bisel, Herman Freckman, Arnoldus Goudsmit, Robert Talley, William Wilson, and Jane C. Wright, it has nearly 45,000 members worldwide. Physician education ASCO offers educational resources for cancer physicians and other health care professionals of clinical oncology. These include scientific meetings, educational conferences, professional workshops, and special symposia on issues of particular relevance and importance to oncologists and researchers. It also produced the patient information website, Cancer.Net. It publishes numerous journals, books, newsletters, and online and multimedia resources; it publishes the ''Journal of Clinical Oncology The ''Journal of Clinical Oncology'' is a peer-reviewed medical journal published 3 times a month by the Lippincott Williams ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American College Of Surgeons
The American College of Surgeons is an educational association of surgeons created in 1913.American College of Surgeons Online "What is the American College of Surgeons?"/ref> See also *American College of Physicians The American College of Physicians (ACP) is a national organization of internists, who specialize in the diagnosis, treatment, and care of adults.Sokanu "What is an Internist?" Retrieved October 20, 2014 With 161,000 members, ACP is the largest ... References External links *ACS Foundation [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabotropic Glutamate Receptors
The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter. Function and structure The mGluRs perform a variety of functions in the central and peripheral nervous systems: For example, they are involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Like other metabotropic receptors, mGluRs have seven transmembrane domains that span the cell membrane. Unlike ionotropic receptors, metabotropic glutamate receptors are not ion channels. Instead, they activate biochemical cascades, leading to the modification of o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endothelium
The endothelium is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. Endothelial cells form the barrier between vessels and tissue and control the flow of substances and fluid into and out of a tissue. Endothelial cells in direct contact with blood are called vascular endothelial cells whereas those in direct contact with lymph are known as lymphatic endothelial cells. Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries. These cells have unique functions that include fluid filtration, such as in the glomerulus of the kidney, blood vessel tone, hemostasis, neutrophil recruitment, and hormone trafficking. Endothelium of the interior surfaces of the heart chambers is called endocardium. An impaired function can lead to serious health issues throug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription (genetics)
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA ( Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA. Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Transcription proceeds in the following general steps: # RNA polymerase, together with one or more general transcription factors, binds to promoter DNA ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PR Newswire
PR Newswire is a distributor of press releases headquartered in Chicago. The service was created in 1954 to allow companies to electronically send press releases to news organizations, using teleprinters at first. The founder, Herbert Muschel, operated the service from his house in Manhattan for approximately 15 years. The business was eventually sold to Western Union and then United Newspapers of London. In December 2015, Cision Inc. announced it would acquire the company. On January 1, 2021, Cision formally merged PR Newswire into the company, ending its status as a legal entity after 66 years. Cision plans to continue utilizing the brand name for the foreseeable future in the United States, as well as in Europe and the Asia-Pacific regions. History PR Newswire was founded in March 1954 by Herbert Muschel, who ran the business from his town house in New York City for the first 15 years of its operation. The company used telecommunications lines and teleprinters owned by Weste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rutgers University
Rutgers University (; RU), officially Rutgers, The State University of New Jersey, is a Public university, public land-grant research university consisting of four campuses in New Jersey. Chartered in 1766, Rutgers was originally called Queen's College, and was affiliated with the Reformed Church in America, Dutch Reformed Church. It is the eighth-oldest college in the United States, the second-oldest in New Jersey (after Princeton University), and one of the nine U.S. colonial colleges that were chartered before the American Revolution.Stoeckel, Althea"Presidents, professors, and politics: the colonial colleges and the American revolution", ''Conspectus of History'' (1976) 1(3):45–56. In 1825, Queen's College was renamed Rutgers College in honor of Colonel Henry Rutgers, whose substantial gift to the school had stabilized its finances during a period of uncertainty. For most of its existence, Rutgers was a Private university, private liberal arts college but it has evolved int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Wood Johnson Medical School
Rutgers Robert Wood Johnson Medical School is a medical school of Rutgers University. It is one of the two graduate medical schools of Rutgers Biomedical and Health Sciences, together with New Jersey Medical School, and is closely aligned with Robert Wood Johnson University Hospital, the medical school's principal affiliate. Rutgers Robert Wood Johnson Medical School operates campuses in Piscataway and New Brunswick in New Jersey. The medical school includes 20 basic science and clinical departments and a broad range of clinical programs conducted at its 34 hospital affiliates and numerous ambulatory care sites in the region. The school is named after Robert Wood Johnson II, the former president and chairman of the board of Johnson & Johnson. Prior to July 2013, Robert Wood Johnson Medical School was part of the University of Medicine and Dentistry of New Jersey (UMDNJ). In 2015-16 admissions cycle, the medical school has introduced the CASPer test, developed by McMaster Universi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
