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David E. Clemmer
David E. Clemmer (February 23, 1965, Alamosa, Colorado) is an analytical chemist and the Distinguished Professor and Robert and Marjorie Mann Chair of Chemistry at Indiana University in Bloomington, Indiana, where he leads the Clemmer Group. Clemmer develops new scientific instruments for ion mobility mass spectrometry (IMS/MS), including the first instrument for nested ion-mobility time-of-flight mass spectrometry. He has received a number of awards, including the Biemann Medal in 2006 "for his pioneering contributions to the integration of ion mobility separations with a variety of mass spectrometry technologies." Early life and education Clemmer was born on February 23, 1965, to Ed Clemmer, an artist, and his wife MaryAnn, a teacher, of Alamosa, Colorado. He attended Adams State College, where he originally majored in music, before changing to science. He received his B.S. in chemistry with honors in 1987. He then attended the University of Utah, receiving his Ph.D. in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alamosa, Colorado
Alamosa is a home rule municipality and the county seat of Alamosa County, Colorado, United States. The city population was 9,806 at the 2020 United States Census. The city is the commercial center of the San Luis Valley in south-central Colorado, and is the home of Adams State University. History Alamosa was established in May 1878 by the Denver and Rio Grande Railroad and quickly became an important rail center. Alamosa was the terminus of the D&RG until 1881, when the line was extended to Monte Vista. The railroad had an extensive construction, repair and shipping facility in Alamosa for many years and headquartered its remaining narrow gauge service here with trackage reaching many points throughout southwest Colorado and northern New Mexico. Alamosa is now a notable tourist town with many nearby attractions, including the Great Sand Dunes National Park and Preserve, Colorado Gators Reptile Park and the Rio Grande Scenic Railroad. The town hosts "Summer Fest on the Rio" whic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jesse L
Jesse may refer to: People and fictional characters * Jesse (biblical figure), father of David in the Bible. * Jesse (given name), including a list of people and fictional characters * Jesse (surname), a list of people Music * ''Jesse'' (album), a 2003 album by Jesse Powell * "Jesse", a 1973 song by Roberta Flack - see Roberta Flack discography * "Jesse", a song from the album ''Valotte'' by Julian Lennon * "Jesse", a song from the album ''The People Tree'' by Mother Earth * "Jesse" (Carly Simon song), a 1980 song * "Jesse", a song from the album ''The Drift'' by Scott Walker * "Jesse", a song from the album '' If I Were Your Woman'' by Stephanie Mills Other * ''Jesse'' (film), a 1988 American television film * ''Jesse'' (TV series), a sitcom starring Christina Applegate * ''Jesse'' (novel), a 1994 novel by Gary Soto * ''Jesse'' (picture book), a 1988 children's book by Tim Winton * Jesse, West Virginia, an unincorporated community * Jesse Hall, University of Missouri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glycomics
Glycomics is the comprehensive study of glycomes (the entire complement of sugars, whether free or present in more complex molecules of an organism), including genetic, physiologic, pathologic, and other aspects. Glycomics "is the systematic study of all glycan structures of a given cell type or organism" and is a subset of glycobiology. The term glycomics is derived from the chemical prefix for sweetness or a sugar, "glyco-", and was formed to follow the ''omics'' naming convention established by genomics (which deals with genes) and proteomics (which deals with proteins). Challenges *The complexity of sugars: regarding their structures, they are not linear instead they are highly branched. Moreover, glycans can be modified (modified sugars), this increases its complexity. *Complex biosynthetic pathways for glycans. *Usually glycans are found either bound to protein (glycoprotein) or conjugated with lipids (glycolipids). *Unlike genomes, glycans are highly dynamic. This area of r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proteomics
Proteomics is the large-scale study of proteins. Proteins are vital parts of living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replication of DNA. In addition, other kinds of proteins include antibodies that protect an organism from infection, and hormones that send important signals throughout the body. The proteome is the entire set of proteins produced or modified by an organism or system. Proteomics enables the identification of ever-increasing numbers of proteins. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain that has benefited greatly from the genetic information of various genome projects, including the Human Genome Project. It covers the exploration of proteomes from the overall level of protein composition, structure, and activity, and is an important component of functional genomics. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipidomics
Lipidomics is the large-scale study of pathways and networks of cellular lipids in biological systems The word "lipidome" is used to describe the complete lipid profile within a cell, tissue, organism, or ecosystem and is a subset of the "metabolome" which also includes other major classes of biological molecules (such as amino acids, sugars, glycolysis & TCA intermediates, and nucleic acids). Lipidomics is a relatively recent research field that has been driven by rapid advances in technologies such as mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, fluorescence spectroscopy, dual polarisation interferometry and computational methods, coupled with the recognition of the role of lipids in many metabolic diseases such as obesity, atherosclerosis, stroke, hypertension and diabetes. This rapidly expanding field complements the huge progress made in genomics and proteomics, all of which constitute the family of systems biology. Lipidomics research involves the id ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytochrome C
The cytochrome complex, or cyt ''c'', is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion. It belongs to the cytochrome c family of proteins and plays a major role in cell apoptosis. Cytochrome c is highly water-soluble, unlike other cytochromes, and is an essential component of the respiratory electron transport chain, where it carries one electron. It is capable of undergoing oxidation and reduction as its iron atom converts between the ferrous and ferric forms, but does not bind oxygen. It transfers electrons between Complexes III (Coenzyme Q – Cyt c reductase) and IV (Cyt c oxidase). In humans, cytochrome c is encoded by the ''CYCS'' gene. Species distribution Cytochrome c is a highly conserved protein across the spectrum of eukaryotic species, found in plants, animals, fungi, and many unicellular organisms. This, along with its small size (molecular weight about 12,000 daltons), makes it useful in studies of cladistics. Cyt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemeprotein
A hemeprotein (or haemprotein; also hemoprotein or haemoprotein), or heme protein, is a protein that contains a heme prosthetic group. They are a very large class of metalloproteins. The heme group confers functionality, which can include oxygen carrying, oxygen reduction, electron transfer, and other processes. Heme is bound to the protein either covalently or noncovalently or both. The heme consists of iron cation bound at the center of the conjugate base of the porphyrin, as well as other ligands attached to the "axial sites" of the iron. The porphyrin ring is a planar dianionic, tetradentate ligand. The iron is typically Fe2+ or Fe3+. One or two ligands are attached at the axial sites. The porphyrin ring has 4 nitrogen atoms that bind to the iron, leaving two other coordination positions of the iron available for bonding to the histidine of the protein and a divalent atom. Hemeproteins probably evolved to incorporate the iron atom contained within the protoporphyrin IX rin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion-mobility Spectrometry–mass Spectrometry
Ion mobility spectrometry–mass spectrometry (IMS-MS) is an analytical chemistry method that separates gas phase ions based on their interaction with a collision gas and their masses. In the first step, the ions are separated according to their mobility through a buffer gas on a millisecond timescale using an ion mobility spectrometer. The separated ions are then introduced into a mass analyzer in a second step where their mass-to-charge ratios can be determined on a microsecond timescale. The effective separation of analytes achieved with this method makes it widely applicable in the analysis of complex samples such as in proteomics and metabolomics. History Earl W. McDaniel has been called the father of ion mobility mass spectrometry. In the early 1960s, he coupled a low-field ion mobility drift cell to a sector mass spectrometer. The combination of time-of-flight mass spectrometry and ion mobility spectrometry was pioneered in 1963 at Bell Labs. In 1963 McAfee and Edelson pub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biomolecule
A biomolecule or biological molecule is a loosely used term for molecules present in organisms that are essential to one or more typically biological processes, such as cell division, morphogenesis, or development. Biomolecules include large macromolecules (or polyelectrolytes) such as proteins, carbohydrates, lipids, and nucleic acids, as well as small molecules such as primary metabolites, secondary metabolites and natural products. A more general name for this class of material is biological materials. Biomolecules are an important element of living organisms, those biomolecules are often endogenous, produced within the organism but organisms usually need exogenous biomolecules, for example certain nutrients, to survive. Biology and its subfields of biochemistry and molecular biology study biomolecules and their reactions. Most biomolecules are organic compounds, and just four elements—oxygen, carbon, hydrogen, and nitrogen—make up 96% of the human body's mass. But ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion Mobility Spectrometry Diagram
An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by convention. The net charge of an ion is not zero because its total number of electrons is unequal to its total number of protons. A cation is a positively charged ion with fewer electrons than protons while an anion is a negatively charged ion with more electrons than protons. Opposite electric charges are pulled towards one another by electrostatic force, so cations and anions attract each other and readily form ionic compounds. Ions consisting of only a single atom are termed atomic or monatomic ions, while two or more atoms form molecular ions or polyatomic ions. In the case of physical ionization in a fluid (gas or liquid), "ion pairs" are created by spontaneous molecule collisions, where each generated pair consists of a free electron and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Julie A
Julie may refer to: * Julie (given name), a list of people and fictional characters with the name Film and television * ''Julie'' (1956 film), an American film noir starring Doris Day * ''Julie'' (1975 film), a Hindi film by K. S. Sethumadhavan featuring Lakshmi * ''Julie'' (1998 film), a British public information film about seatbelt use * ''Julie'' (2004 film), a Hindi film starring Neha Dhupia * ''Julie'' (2006 film), a Kannada film starring Ramya * ''Julie'' (TV series), a 1992 American sitcom starring Julie Andrews Literature * ''Julie; or, The New Heloise'', a 1761 novel by Jean-Jacques Rousseau * ''Julie'' (George novel), a 1994 novel, the second book of a trilogy, by Jean Craighead George * ''Julie'', a 1985 novel by Cora Taylor Music * ''Julie'' (opera), a 2005 opera by Philippe Boesmans Albums * ''Julie'' (album), by Julie London, 1957 * ''Julie'' (EP) or the title song, by Jens Lekman, 2004 Songs * "Julie", by Doris Day, 1956 * "Julie" (Daniel song), by D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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