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Dainippon Sumitomo Pharma
is a pharmaceutical company based in Japan. Its headquarters are in Chuo-ku, Osaka. The original Dainippon Pharmaceuticals (Dainippon Seiyaku) was established in 1885 by Nagayo Sensai, a graduate of Tekijuku – the first private medical school in Japan established by Ogata Kōan. It was set up as a wholly privately-owned company funded by individuals from Tokyo and Osaka, with the land and buildings lent by the government. Technical expertise for the enterprise was provided by Shibata Shokei and Nagai Nagayoshi. The company started its operation in 1885 with equipment imported from Germany. The main products were tincture and other similar drugs listed in the Japanese Pharmacopoeia. Among them was ephedrine, an anti-asthma drug invented by Nagai. In 1893, however, Nagai left the company and the business started to post operating losses. In 1898 it was acquired by Osaka Seiyaku (Osaka Pharmaceutical). Another origin of the company began as Sumitomo Pharmaceuticals, incorporate ...
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Public Company
A public company is a company whose ownership is organized via shares of stock which are intended to be freely traded on a stock exchange or in over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listed company), which facilitates the trade of shares, or not (unlisted public company). In some jurisdictions, public companies over a certain size must be listed on an exchange. In most cases, public companies are ''private'' enterprises in the ''private'' sector, and "public" emphasizes their reporting and trading on the public markets. Public companies are formed within the legal systems of particular states, and therefore have associations and formal designations which are distinct and separate in the polity in which they reside. In the United States, for example, a public company is usually a type of corporation (though a corporation need not be a public company), in the United Kingdom it is usually a public limited company (plc), i ...
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Cynapsus Therapeutics
Cynapsus Therapeutics Inc. is a specialty pharmaceutical company developing a drug to treat the motor symptoms of Parkinson's disease. Based in Toronto, Ontario, Canada. Formerly named Cannasat Therapeutics they changed their name to Cynapsus Therapeutics in 2010. In September 2016, Sunovion (a subsidiary of Dainippon Sumitomo Pharma is a pharmaceutical company based in Japan. Its headquarters are in Chuo-ku, Osaka. The original Dainippon Pharmaceuticals (Dainippon Seiyaku) was established in 1885 by Nagayo Sensai, a graduate of Tekijuku – the first private medical school ...) announced it would acquire Cynapsus Therapeutics for approximately $624 million. Company Overview Cynapsus is a specialty pharmaceutical company developing the only oral (sublingual) delivery of the only approved drug (apomorphine) to treat the motor symptoms of Parkinson's disease. Over one million people in the United States and an estimated 5 million people globally suffer from Parkinson's diseas ...
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Marlborough, Massachusetts
Marlborough is a city in Middlesex County, Massachusetts, United States. The population was 41,793 at the 2020 census. Marlborough became a prosperous industrial town in the 19th century and made the transition to high technology industry in the late 20th century after the construction of the Massachusetts Turnpike. Marlborough was declared a town in 1660. It was incorporated as a city in 1890 when it changed its municipal charter from a New England town meeting system to a mayor–council government. History John Howe in 1656 was a fur trader and built a house at the intersection of two Indian trails, Nashua Trail and Connecticut path. He could speak the language of the Algonquian Indians though the local tribe referred to themselves as the Pennacooks. The settlers were welcomed by the Indians because they protected them from other tribes they were at war with. In the 1650s, several families left the nearby town of Sudbury, 18 miles west of Boston, to start a new town. The ...
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Sunovion
Sunovion Pharmaceuticals Inc. (former NASDAQ: ''SEPR''), known until October 12, 2010 as Sepracor, Inc. prior to its acquisition by Sumitomo Pharma of Japan, is a pharmaceutical company founded in 1984 by Timothy J. Barberich, Steve Matson, and Bob Bratzler. It was originally located in Princeton, New Jersey and then re-located to Marlborough, Massachusetts. In addition to its headquarters in Marlborough, Sunovion has locations in Mississauga, Ontario, and Teaneck, New Jersey. Company history The company's initial focus was on the separation and purification of isomers and active metabolites. Sepracor completed its initial public offering in 1991 at a market cap of $160M, behind a strategy of presenting larger pharmaceuticals with patented, purified active ingredients for expiring products. In 1993, Marion Merrell Dow, now a part of Sanofi, partnered with Sepracor to develop a purified version of its antihistamine, Seldane, after the latter was required to carry a warning about ...
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Dainippon Sumitomo Pharma
is a pharmaceutical company based in Japan. Its headquarters are in Chuo-ku, Osaka. The original Dainippon Pharmaceuticals (Dainippon Seiyaku) was established in 1885 by Nagayo Sensai, a graduate of Tekijuku – the first private medical school in Japan established by Ogata Kōan. It was set up as a wholly privately-owned company funded by individuals from Tokyo and Osaka, with the land and buildings lent by the government. Technical expertise for the enterprise was provided by Shibata Shokei and Nagai Nagayoshi. The company started its operation in 1885 with equipment imported from Germany. The main products were tincture and other similar drugs listed in the Japanese Pharmacopoeia. Among them was ephedrine, an anti-asthma drug invented by Nagai. In 1893, however, Nagai left the company and the business started to post operating losses. In 1898 it was acquired by Osaka Seiyaku (Osaka Pharmaceutical). Another origin of the company began as Sumitomo Pharmaceuticals, incorporate ...
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Sumitomo Chemical
is a major Japanese chemical company. The company is listed on the first section of the Tokyo Stock Exchange and is a constituent of the on the Nikkei 225 stock index. It's a member of the Sumitomo group and was founded in 1913 as a fertilizer manufacturing plant. Company milestones *1913: The House of Sumitomo establishes a fertilizer plant in Ehime to produce fertilizers from sulfur dioxide recovered from copper smelting emissions. *1915: Operations commence at the plant. *1925: Sumitomo Fertilizer Manufacturing Co., Ltd. is incorporated with operations at what is now the Ehime Works. *1934: Sumitomo Fertilizer Manufacturing changes its name to Sumitomo Chemical Co., Ltd. *1944: Sumitomo Chemical acquires Japan Dyestuff Manufacturing Company, starting a fine chemical business at the Osaka Works and the Oita Works. *1949: Sumitomo Chemical takes over the aluminum business of Sumitomo Aluminium Smelting Co., starting the integrated production of aluminum from alumina. *1958: S ...
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Asthma
Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. These may occur a few times a day or a few times per week. Depending on the person, asthma symptoms may become worse at night or with exercise. Asthma is thought to be caused by a combination of genetic and environmental factors. Environmental factors include exposure to air pollution and allergens. Other potential triggers include medications such as aspirin and beta blockers. Diagnosis is usually based on the pattern of symptoms, response to therapy over time, and spirometry lung function testing. Asthma is classified according to the frequency of symptoms, forced expiratory volume in one second (FEV1), and peak expiratory flow rate. It may also be classified as atopic or non-atopic, ...
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Ephedrine
Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in nasal congestion. It can be taken by mouth or by injection into a muscle, vein, or just under the skin. Onset with intravenous use is fast, while injection into a muscle can take 20 minutes, and by mouth can take an hour for effect. When given by injection it lasts about an hour and when taken by mouth it can last up to four hours. Common side effects include trouble sleeping, anxiety, headache, hallucinations, high blood pressure, fast heart rate, loss of appetite, and inability to urinate. Serious side effects include stroke and heart attack. While likely safe in pregnancy, its use in this population is poorly studied. Use during breastfeeding is not recommended. Ephedrine works by increasing the activity of the α and β adrenergic ...
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Pharmacopoeia
A pharmacopoeia, pharmacopeia, or pharmacopoea (from the obsolete typography ''pharmacopœia'', meaning "drug-making"), in its modern technical sense, is a book containing directions for the identification of compound medicines, and published by the authority of a government or a medical or pharmaceutical society. Descriptions of preparations are called monographs. In a broader sense it is a reference work for pharmaceutical drug specifications. Etymology The term derives from grc, φαρμακοποιία ''pharmakopoiia'' "making of (healing) medicine, drug-making", a compound of φάρμακον ''pharmakon'' "healing medicine, drug, poison", the verb ποιεῖν ''poiein'' "to make" and the abstract noun suffix -ία ''-ia''. In early modern editions of Latin texts, the Greek diphthong οι (''oi'') is latinized to its Latin equivalent ''oe'' which is in turn written with the ligature ''œ'', giving the spelling ''pharmacopœia''; in modern UK English, ''œ'' is wri ...
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Tincture
A tincture is typically an extract of plant or animal material dissolved in ethanol (ethyl alcohol). Solvent concentrations of 25–60% are common, but may run as high as 90%.Groot Handboek Geneeskrachtige Planten by Geert Verhelst In chemistry, a tincture is a solution that has ethanol as its solvent. In herbal medicine, alcoholic tinctures are made with various ethanol concentrations, which should be at least 20% alcohol for preservation purposes. Other solvents for producing tinctures include vinegar, glycerol (also called glycerine), diethyl ether and propylene glycol, not all of which can be used for internal consumption. Ethanol has the advantage of being an excellent solvent for both acidic and basic (alkaline) constituents. A tincture using glycerine is called a glycerite. Glycerine is generally a poorer solvent than ethanol. Vinegar, being acidic, is a better solvent for obtaining alkaloids but a poorer solvent for acidic components. For individuals who choose not to i ...
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Nagai Nagayoshi
was a Japanese pharmacist, best known for his study of ephedrine. Early life Nagai was born in Myōdō District, Awa Province in what is now Tokushima Prefecture, as the son of a doctor and started studying ''rangaku'' medicine at the Dutch Medical School of Nagasaki ''( Igaku-Denshujo)'' in 1864. While in Nagasaki, he made the acquaintance of Ōkubo Toshimichi, Itō Hirobumi, and other future leaders of the Meiji government. Career Nagai continued his studies at Tokyo Imperial University and became the first doctor of pharmacy in Japan. He was sent under government sponsorship to Prussia in 1871 to study at the University of Berlin. He was the only civilian in a group of military students sent to study in Great Britain and France, and he traveled by way of the United States and Great Britain. While in Berlin, he resided at the home of Japanese diplomat Aoki Shūzō. He was influenced by the lectures of von Hofmann, and received a doctorate with a study on eugenol while wor ...
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