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D.S.Falconer
Douglas Scott Falconer (10 March 1913 in Oldmeldrum, Aberdeenshire – 23 February 2004 in Edinburgh) was a Scottish geneticist known for his work in quantitative genetics. Falconer's book ''Introduction to quantitative genetics'' was written in 1960 and became a valuable reference for generations of scientists. Its latest edition dates back to 1996 and is coauthored by Trudy Mackay. Falconer graduated with first class honors in zoology from the University of St Andrews in 1940. He then received his PhD from the University of Cambridge in 1943. He eventually got an honorary ScD from Cambridge in 1969. In 1951, Falconer described a novel mouse mutant that he called reeler for its peculiar gait. Later research using these mice has led to the discovery of reelin, a protein playing important roles in corticogenesis, neuronal migration, and plasticity Plasticity may refer to: Science * Plasticity (physics), in engineering and physics, the propensity of a solid mat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reelin
Reelin, encoded by the ''RELN'' gene, is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like the subventricular and subgranular zones. It is found not only in the brain but also in the liver, thyroid gland, adrenal gland, Fallopian tube, breast and in comparatively lower levels across a range of anatomical regions. Reelin has been suggested to be implicated in pathogenesis of several brain diseases. The expression of the protein has been found to be significantly lower in schizophrenia and psycho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Old Meldrum
Oldmeldrum (commonly known as Meldrum) is a village and parish in the Formartine area of Aberdeenshire, not far from Inverurie in North East Scotland. With a population of around 2,187, Oldmeldrum falls within Scotland's top 300 centres of population. Oldmeldrum is home to one of the oldest whisky distilleries in Scotland, Glen Garioch, which was built in 1797. Local industries are agriculture and engineering services connected to the oil industry in Aberdeen. Prehistory and archaeology Archaeological excavations in advance of the construction of a new bypass road around the north of Oldmeldrum, in the summer 2005, revealed the remains of three Bronze Age ring-ditch roundhouses. The archaeologists believe that the houses that might be part of an area of open settlement which means the first settlement at Oldmeldrum was 3500 years ago. History The Battle of Barra was fought in May 1308 (some say earlier) near the Hill of Barra between the armies of Scots King Robert Bruce an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Honorary Degree
An honorary degree is an academic degree for which a university (or other degree-awarding institution) has waived all of the usual requirements. It is also known by the Latin phrases ''honoris causa'' ("for the sake of the honour") or ''ad honorem '' ("to the honour"). The degree is typically a doctorate or, less commonly, a master's degree, and may be awarded to someone who has no prior connection with the academic institution or no previous postsecondary education. An example of identifying a recipient of this award is as follows: Doctorate in Business Administration (''Hon. Causa''). The degree is often conferred as a way of honouring a distinguished visitor's contributions to a specific field or to society in general. It is sometimes recommended that such degrees be listed in one's curriculum vitae (CV) as an award, and not in the education section. With regard to the use of this honorific, the policies of institutions of higher education generally ask that recipients ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alumni Of The University Of St Andrews
Alumni (singular: alumnus (masculine) or alumna (feminine)) are former students of a school, college, or university who have either attended or graduated in some fashion from the institution. The feminine plural alumnae is sometimes used for groups of women. The word is Latin and means "one who is being (or has been) nourished". The term is not synonymous with "graduate"; one can be an alumnus without graduating ( Burt Reynolds, alumnus but not graduate of Florida State, is an example). The term is sometimes used to refer to a former employee or member of an organization, contributor, or inmate. Etymology The Latin noun ''alumnus'' means "foster son" or "pupil". It is derived from PIE ''*h₂el-'' (grow, nourish), and it is a variant of the Latin verb ''alere'' "to nourish".Merriam-Webster: alumnus .. Separate, but from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2004 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day The following pages, corresponding to the Gregorian calendar, list the historical events, births, deaths, and holidays and observances of the specified day of the year: Footnotes See also * Leap year * List of calendars * List of non-standard ... * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1913 Births
Events January * January 5 – First Balkan War: Battle of Lemnos – Greek admiral Pavlos Kountouriotis forces the Turkish fleet to retreat to its base within the Dardanelles, from which it will not venture for the rest of the war. * January 13 – Edward Carson founds the (first) Ulster Volunteer Force, by unifying several existing loyalist militias to resist home rule for Ireland. * January 23 – 1913 Ottoman coup d'état: Ismail Enver comes to power. * January – Stalin (whose first article using this name is published this month) travels to Vienna to carry out research. Until he leaves on February 16 the city is home simultaneously to him, Hitler, Trotsky and Tito alongside Berg, Freud and Jung and Ludwig and Paul Wittgenstein. February * February 1 – New York City's Grand Central Terminal, having been rebuilt, reopens as the world's largest railroad station. * February 3 – The 16th Amendment to the United S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Falconer's Formula
Heritability is the proportion of variance caused by genetic factors of a specific trait in a population. Falconer's formula is a mathematical formula that is used in twin studies to estimate the relative contribution of genetic vs. environmental factors to variation in a particular trait (that is, the heritability of the trait) based on the difference between twin correlations. Statistical models for heritability commonly include an error that will absorb phenotypic variation that cannot be described by genetics when analyzed. These are unique subject-specific influences on a trait. Falconer's formula was first proposed by the Scottish geneticist Douglas Falconer. The formula is ^2 = 2(r_ - r_) where ^2 is the broad sense heritability, r_ is the (monozygotic, MZ) identical twin correlation, and r_ is the (dizygotic, DZ) fraternal twin correlation. Falconer's formula assumes the equal contribution of environmental factors in MZ pairs and DZ pairs. Therefore, additional phenotypic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Glasgow Herald
''The Herald'' is a Scottish broadsheet newspaper founded in 1783. ''The Herald'' is the longest running national newspaper in the world and is the eighth oldest daily paper in the world. The title was simplified from ''The Glasgow Herald'' in 1992. Following the closure of the ''Sunday Herald'', the ''Herald on Sunday'' was launched as a Sunday edition on 9 September 2018. History Founding The newspaper was founded by an Edinburgh-born printer called John Mennons in January 1783 as a weekly publication called the ''Glasgow Advertiser''. Mennons' first edition had a global scoop: news of the treaties of Versailles reached Mennons via the Lord Provost of Glasgow just as he was putting the paper together. War had ended with the American colonies, he revealed. ''The Herald'', therefore, is as old as the United States of America, give or take an hour or two. The story was, however, only carried on the back page. Mennons, using the larger of two fonts available to him, put it in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fellow Of The Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, including mathematics, engineering science, and medical science". Fellow, Fellowship of the Society, the oldest known scientific academy in continuous existence, is a significant honour. It has been awarded to many eminent scientists throughout history, including Isaac Newton (1672), Michael Faraday (1824), Charles Darwin (1839), Ernest Rutherford (1903), Srinivasa Ramanujan (1918), Albert Einstein (1921), Paul Dirac (1930), Winston Churchill (1941), Subrahmanyan Chandrasekhar (1944), Dorothy Hodgkin (1947), Alan Turing (1951), Lise Meitner (1955) and Francis Crick (1959). More recently, fellowship has been awarded to Stephen Hawking (1974), David Attenborough (1983), Tim Hunt (1991), Elizabeth Blackburn (1992), Tim Berners-Lee (2001), Venki R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Threshold Model
In mathematical or statistical modeling a threshold model is any model where a threshold value, or set of threshold values, is used to distinguish ranges of values where the behaviour predicted by the model varies in some important way. A particularly important instance arises in toxicology, where the model for the effect of a drug may be that there is zero effect for a dose below a critical or threshold value, while an effect of some significance exists above that value.Dodge, Y. (2003) ''The Oxford Dictionary of Statistical Terms'', OUP. Certain types of regression model may include threshold effects. Collective behavior Threshold models are often used to model the behavior of groups, ranging from social insects to animal herds to human society. Classic threshold models were introduced by Sakoda, in his 1949 dissertation and the Journal of Mathematical Sociology (JMS vol 1 #1, 1971). They were subsequently developed by Schelling, Axelrod, and Granovetter to model collective be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuronal Plasticity
Neuroplasticity, also known as neural plasticity, or brain plasticity, is the ability of neural networks in the brain to change through growth and reorganization. It is when the brain is rewired to function in some way that differs from how it previously functioned. These changes range from individual neuron pathways making new connections, to systematic adjustments like cortical remapping. Examples of neuroplasticity include circuit and network changes that result from learning a new ability, environmental influences, practice, and psychological stress. Neuroplasticity was once thought by neuroscientists to manifest only during childhood, but research in the latter half of the 20th century showed that many aspects of the brain can be altered (or are "plastic") even through adulthood. However, the developing brain exhibits a higher degree of plasticity than the adult brain. Activity-dependent plasticity can have significant implications for healthy development, learning, memory, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuronal Migration
The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The field of neural development draws on both neuroscience and developmental biology to describe and provide insight into the cellular and molecular mechanisms by which complex nervous systems develop, from nematodes and fruit flies to mammals. Defects in neural development can lead to malformations such as holoprosencephaly, and a wide variety of neurological disorders including limb paresis and paralysis, balance and vision disorders, and seizures, and in humans other disorders such as Rett syndrome, Down syndrome and intellectual disability. Overview of vertebrate brain development The vertebrate central nervous system (CNS) is derived from the ectoderm—the outermost germ layer of the embryo. A part of the dorsal ectoderm becomes specifie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
