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CytRx
CytRx Corp. () is a biopharmaceutical research and development oncology company based in Los Angeles, California. The CytRx oncology pipeline includes clinical trials involving their lead drug aldoxorubicin. Aldoxorubicin (formerly INNO-206) is a modified form of doxorubicin, the popular anthracycline chemotherapeutic agent known as "red death". Anthracyclines are a class of drugs that are among the most commonly used agents in the treatment of cancer. Doxorubicin, the first anthracycline to gain approval, has demonstrated efficacy in a wide variety of cancers including breast cancer, lung cancer, sarcomas, and lymphomas. However, doxorubicin is associated with side effects such as myelosuppression, gastrointestinal disorders, mucositis, stomatitis, cumulative cardiotoxicity and extravasation. General CytRx plans to expand its pipeline of oncology candidates at its laboratory facilities in Freiburg, Germany, based on novel linker technologies that can be utilized with multiple c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galena Biopharma
Galena Biopharma (originally RXi Pharmaceuticals) was a publicly traded pharmaceutical company based in San Ramon, California. The company was founded in Worcester, Massachusetts. In 2011, it moved to Oregon, and in 2015 moved to San Ramon, California. Mark Schwartz was the company's president and chief executive officer. As of December 29, 2017, the company was acquired by Sellas Life Sciences Group Ltd. through a reverse merger transaction. Galena Biopharma was renamed to Sellas Life Sciences Group, Inc (). History In November 2006, Argonaut Pharmaceuticals, Inc. changed the name to RXi Pharmaceuticals Corporation. RXi was a subsidiary of CytRx Corp., which provided $15 million in financing in April 2007. RXi was founded in part by Nobel Prize winner Craig Mello. In September 2007, RXi signed a licensing deal with TriLink Biotechnologies, a competitor in the RNA interference (RNAi) field, in which RXi would pay TriLink to use three of TriLink's technologies. In March 2011, the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aldoxorubicin
Aldoxorubicin (INNO-206) is a tumor-targeted doxorubicin conjugate in development by CytRx. Specifically, it is the (6- maleimido caproyl) hydrazone of doxorubicin. Essentially, this chemical name describes doxorubicin attached to an acid-sensitive linker (N-ε-maleimidocaproic acid hydrazide, or EMCH). The proposed mechanism of action is as follows: # After administration, aldoxorubicin rapidly binds endogenous circulating albumin through the EMCH linker. # Circulating albumin preferentially accumulates in tumors, bypassing uptake by other non-specific sites including heart, bone marrow and gastrointestinal tract. # Once albumin-bound aldoxorubicin reaches the tumor, the acidic environment of the tumor causes cleavage of the acid sensitive linker. # Free doxorubicin is released at the site of the tumor. Clinical trials Five phase I trials for safety characterization have been completed. Several phase II and III trials are underway. Phase II As of January 2017, there are 6 p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Russell Microcap Index
The Russell Microcap Index measures the performance of the microcap segment of the U.S. equity market. It makes up less than 3% of the U.S. equity market. It includes 1,000 of the smallest securities in the Russell 2000 Index based on a combination of their market cap and current index membership and it also includes up to the next 1,000 stocks. , the weighted average market capitalization for a company in the index was $535 million; the median market cap was $228 million. The market cap of the largest company in the index was $3.6 billion. The index, which was launched on June 1, 2005, is maintained by FTSE Russell, a subsidiary of the London Stock Exchange Group. Its ticker symbol is ^RUMIC. Records In February 2021, during the everything bubble, a record 14 members of the index exceeded the market capitalization of the smallest member of the S&P 500 Index. Investing The Russell Microcap Index is tracked by the iShares Micro-Cap ETF (). Top 10 holdings *Mercury Systems () * Cen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forbes
''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also reports on related subjects such as technology, communications, science, politics, and law. It is based in Jersey City, New Jersey. Competitors in the national business magazine category include ''Fortune'' and ''Bloomberg Businessweek''. ''Forbes'' has an international edition in Asia as well as editions produced under license in 27 countries and regions worldwide. The magazine is well known for its lists and rankings, including of the richest Americans (the Forbes 400), of the America's Wealthiest Celebrities, of the world's top companies (the Forbes Global 2000), Forbes list of the World's Most Powerful People, and The World's Billionaires. The motto of ''Forbes'' magazine is "Change the World". Its chair and editor-in-chief is Steve Fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Companies Of The United States
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and relies on the science of pharmacology for continual advancement and on pharmacy for appropriate management. Drugs are classified in multiple ways. One of the key divisions is by level of control, which distinguishes prescription drugs (those that a pharmacist dispenses only on the order of a physician, physician assistant, or qualified nurse) from over-the-counter drugs (those that consumers can order for themselves). Another key distinction is between traditional small molecule drugs, usually derived from chemical synthesis, and biopharmaceuticals, which include recombinant proteins, vaccines, blood products used therapeutically (such as IVIG), gene therapy, monoclonal antibodies and cell therapy (for instance, stem cell therapies). Ot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Companies Listed On The Nasdaq
A company, abbreviated as co., is a legal entity representing an association of people, whether natural, legal or a mixture of both, with a specific objective. Company members share a common purpose and unite to achieve specific, declared goals. Companies take various forms, such as: * voluntary associations, which may include nonprofit organizations * business entities, whose aim is generating profit * financial entities and banks * programs or educational institutions A company can be created as a legal person so that the company itself has limited liability as members perform or fail to discharge their duty according to the publicly declared incorporation, or published policy. When a company closes, it may need to be liquidated to avoid further legal obligations. Companies may associate and collectively register themselves as new companies; the resulting entities are often known as corporate groups. Meanings and definitions A company can be defined as an "artificial per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MarketWatch
MarketWatch is a website that provides financial information, business news, analysis, and stock market data. Along with ''The Wall Street Journal'' and ''Barron's'', it is a subsidiary of Dow Jones & Company, a property of News Corp. History The company was conceived as DBC Online by Data Broadcasting Corp. in the fall of 1995. The marketwatch.com domain name was registered on July 30, 1997. The website launched on October 30, 1997, as a 50/50 joint venture between DBC and CBS News run by Larry Kramer and with Thom Calandra as editor-in-chief. In 1999, the company hired David Callaway and in 2003, Callaway became editor-in-chief. In January 1999, during the dot-com bubble, the company became a public company via an initial public offering. After pricing at $17 per share, the stock traded as high as $130 per share on its first day of trading, giving it a market capitalization of over $1 billion despite only $7 million in annual revenues. In June 2000, the company formed a j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNNMoney
CNN Business (formerly CNN Money) is a financial news and information website, operated by CNN. The website was originally formed as a joint venture between CNN.com and Time Warner's ''Fortune'' and ''Money'' magazines. Since the spin-off of Time Warner's publishing assets as Time Inc. (and their subsequent sale to Meredith Corporation and later, to IAC's Dotdash), the site has since operated as an affiliate of CNN. History CNN Money launched in 2001, replacing CNNfn's website. Time Warner had also announced an intention to relaunch the CNNfn television network under the CNN Money moniker, but those plans were apparently scrapped. Prior to June 2014, the website was operated as a joint venture between CNN and two Time Warner-published business magazines; ''Fortune'' and ''Money''. In June 2014, Time Warner's publishing assets were spun-out as Time Inc.; as a result, all three properties launched separate web presences, and CNN Money introduced a new logo that removed the wordma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conflict Of Interest
A conflict of interest (COI) is a situation in which a person or organization is involved in multiple interests, financial or otherwise, and serving one interest could involve working against another. Typically, this relates to situations in which the personal interest of an individual or organization might adversely affect a duty owed to make decisions for the benefit of a third party. An "interest" is a commitment, obligation, duty or goal associated with a particular social role or practice. By definition, a "conflict of interest" occurs if, within a particular decision-making context, an individual is subject to two coexisting interests that are in direct conflict with each other. Such a matter is of importance because under such circumstances the decision-making process can be disrupted or compromised in a manner that affects the integrity or the reliability of the outcomes. Typically, a conflict of interest arises when an individual finds themselves occupying two soc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Motley Fool
The Motley Fool is a private financial and investing advice company based in Alexandria, Virginia. It was founded in July 1993 by co-chairmen and brothers David Gardner and Tom Gardner, and Erik Rydholm, who has since left the company. The company employs over 300 people worldwide. Company name The name “Motley Fool” is taken from Shakespeare’s comedy ''As You Like It''. It references the one characterthe court jesterwho could speak the truth to the Duke without having his head lopped off. History Early years In 1994, The Motley Fool published a series of statements online promoting a nonexistent sewage-disposal company. The messages, which were an April Fool's joke designed to teach a lesson about penny stock investing, garnered widespread attention, including an article in ''The Wall Street Journal''. In August that year, the Gardners parlayed their one-year-old investment newsletter into a content partnership with America Online (AOL). In December, they were profiled ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seeking Alpha
Seeking Alpha is a crowd-sourced content service for financial markets. Articles and research covers a broad range of stocks, asset classes, exchange-traded funds (ETFs), and investment strategies. Unlike other equity research platforms, insight is provided by contributors including a base of investors and industry experts (buy side) rather than sell side. Seeking Alpha was founded in 2004 by former Wall Street analyst David Jackson. In 2011 the company stated it had distribution partnerships with MSN Money, CNBC, Yahoo! Finance, MarketWatch, NASDAQ and TheStreet. Yahoo Finance ended its relationship with Seeking Alpha on July 28, 2014. As of January 2021, the firm self-reported that it had 10 million registered users and attracts over 17 million unique viewers every month. Its average visit duration was 4× more than ''The Economist'', ''Barron's'' or the ''Wall Street Journal.'' Contributors The site's content is primarily generated by independent contributors. As of January ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biopharmaceutical
A biopharmaceutical, also known as a biological medical product, or biologic, is any pharmaceutical drug product manufactured in, extracted from, or semisynthesized from biological sources. Different from totally synthesized pharmaceuticals, they include vaccines, whole blood, blood components, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic protein, and living medicines used in cell therapy. Biologics can be composed of sugars, proteins, nucleic acids, or complex combinations of these substances, or may be living cells or tissues. They (or their precursors or components) are isolated from living sources—human, animal, plant, fungal, or microbial. They can be used in both human and animal medicine. Terminology surrounding biopharmaceuticals varies between groups and entities, with different terms referring to different subsets of therapeutics within the general biopharmaceutical category. Some regulatory agencies use the terms ''biological ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
