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ContraPest
ContraPest is the first U.S. EPA registered contraceptive pest control tool designed to reduce fertility in brown and black rats, developed by the U.S. biotechnology company SenesTech. It is a flavored liquid, designed to be attractive to, and to be consumed by, the target animals in order to reduce the population over time. ContraPest is a contraceptive, not a sterilant, so a continuous supply maintains reduced populations. ContraPest was initially tested in Indonesian rice fields, South Carolina pig farms, the suburbs of Boston and the New York City subway, and caused a reduction in rat populations of roughly 40% over a period of 12 weeks. The product was approved for commercial use by the U.S. Environmental Protection Agency in August 2016. History The formula was originally used by Dr. Loretta Mayer and Dr. Cheryl Dyer as part of a research program to study heart disease in post-menopausal women through menopausal mice. The active ingredient of ContraPest is the chemica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pest Control
Pest control is the regulation or management of a species defined as a pest; any animal, plant or fungus that impacts adversely on human activities or environment. The human response depends on the importance of the damage done and will range from tolerance, through deterrence and management, to attempts to completely eradicate the pest. Pest control measures may be performed as part of an integrated pest management strategy. In agriculture, pests are kept at bay by mechanical, cultural, chemical and biological means. Ploughing and cultivation of the soil before sowing mitigate the pest burden, and crop rotation helps to reduce the build-up of a certain pest species. Concern about environment means limiting the use of pesticides in favour of other methods. This can be achieved by monitoring the crop, only applying pesticides when necessary, and by growing varieties and crops which are resistant to pests. Where possible, biological means are used, encouraging the natural enem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pest Control
Pest control is the regulation or management of a species defined as a pest; any animal, plant or fungus that impacts adversely on human activities or environment. The human response depends on the importance of the damage done and will range from tolerance, through deterrence and management, to attempts to completely eradicate the pest. Pest control measures may be performed as part of an integrated pest management strategy. In agriculture, pests are kept at bay by mechanical, cultural, chemical and biological means. Ploughing and cultivation of the soil before sowing mitigate the pest burden, and crop rotation helps to reduce the build-up of a certain pest species. Concern about environment means limiting the use of pesticides in favour of other methods. This can be achieved by monitoring the crop, only applying pesticides when necessary, and by growing varieties and crops which are resistant to pests. Where possible, biological means are used, encouraging the natural enem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triptolide
Triptolide is a diterpenoid epoxide which is produced by the thunder god vine, ''Tripterygium wilfordii''. It has ''in vitro'' and ''in vivo'' activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical properties and severe toxicity limit its therapeutic potential. Consequently, a synthetic water-soluble prodrug, minnelide, is being studied clinically instead. Triptolide is a component of ContraPest, a contraceptive pest control liquid used to reduce rat populations in the United States. Mechanism of action Several putative target proteins of triptolide have been reported, including polycystin-2, ADAM10, DCTPP1, TAB1, and XPB. Multiple triptolide-resistant mutations exist in XPB (ERCC3) and its partner protein GTF2H4.Y. Smurnyy, M. Cai, H. Wu, E. McWhinnie, J. A. Tallarico, Y.Yang, Y. Feng, DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells. ''Nat. Chem. Biol''. 2014, 10, 623 – 625 However, no trip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biotechnology
Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used by Károly Ereky in 1919, meaning the production of products from raw materials with the aid of living organisms. Definition The concept of biotechnology encompasses a wide range of procedures for modifying living organisms according to human purposes, going back to domestication of animals, cultivation of the plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization. Modern usage also includes genetic engineering as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as the application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gateway Arch National Park
Gateway Arch National Park is an American national park located in St. Louis, Missouri, near the starting point of the Lewis and Clark Expedition. The memorial was established to commemorate: *the Louisiana Purchase and subsequent westward movement of American explorers and pioneers; *the first civil government west of the Mississippi River; and *the debate over slavery raised by the ''Dred Scott'' case. The national park consists of the Gateway Arch, a steel catenary arch that has become the definitive icon of St. Louis; a park along the Mississippi River on the site of the earliest buildings of the city; the Old Courthouse, a former state and federal courthouse where the ''Dred Scott'' case originated; and the museum at the Gateway Arch. At 91 acres (36.8 hectares), it is the smallest national park in the United States. The immediate surroundings of the Gateway Arch were initially designated the Jefferson National Expansion Memorial (a national memorial) by executive or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovarian Follicle
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle. At the time of puberty, women have approximately 200,000 to 300,000 follicles, each with the potential to release an egg cell (ovum) at ovulation for fertilization. These eggs are developed once every menstrual cycle with around 450–500 being ovulated during a woman's reproductive lifetime. Structure Ovarian follicles are the basic units of female reproductive biology. Each of them contains a single oocyte (immature ovum or egg cell). These structures are periodically initiated to grow and develop, culminating in ovulation of usually a single competent oocyte in humans. They also consist of granulosa cells and theca of follicle. Oocyte Once a month, one of the ovaries releases a mature egg (ovum), known as an oocyte. The nucleus of such an oocyte is called a '' germinal vesicle (see picture).'' Cumulus oophorus Cumulu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oocyte
An oocyte (, ), oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction. In other words, it is an immature ovum, or egg cell. An oocyte is produced in a female fetus in the ovary during female gametogenesis. The female germ cells produce a primordial germ cell (PGC), which then undergoes mitosis, forming oogonia. During oogenesis, the oogonia become primary oocytes. An oocyte is a form of genetic material that can be collected for cryoconservation. Formation The formation of an oocyte is called oocytogenesis, which is a part of oogenesis. Oogenesis results in the formation of both primary oocytes during fetal period, and of secondary oocytes after it as part of ovulation. Characteristics Cytoplasm Oocytes are rich in cytoplasm, which contains yolk granules to nourish the cell early in development. Nucleus During the primary oocyte stage of oogenesis, the nucleus is called a germinal vesicle. The only normal human type of secondary oocyte has t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-vinylcyclohexene Diepoxide
4-Vinylcyclohexene dioxide (VCD) is an organic compound that contains two epoxide functional groups. It is industrially used as a crosslinking agent for the production of epoxy resins. It is a colourless liquid. It is an intermediate for synthesis of organic compounds. Preparation and properties 4-Vinylcyclohexene dioxide is prepared by epoxidation of 4-vinylcyclohexene with peroxybenzoic acid. Its viscosity is 15 mPa·s. Safety 4-Vinylcyclohexene dioxide, like other volatile epoxides, is classified as an alkylating agent. VCD has toxic effects on fertility. It is a killer of oocytes, eggs in a female's ovaries, in immature ovarian follicles in mice and rats Rats are various medium-sized, long-tailed rodents. Species of rats are found throughout the order Rodentia, but stereotypical rats are found in the genus ''Rattus''. Other rat genera include ''Neotoma'' (pack rats), ''Bandicota'' (bandicoot .... In pest control, it has been used as an ovotoxic agent for reducing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Menopause
Menopause, also known as the climacteric, is the time in women's lives when menstrual periods stop permanently, and they are no longer able to bear children. Menopause usually occurs between the age of 47 and 54. Medical professionals often define menopause as having occurred when a woman has not had any menstrual bleeding for a year. It may also be defined by a decrease in hormone production by the ovaries. In those who have had surgery to remove their uterus but still have functioning ovaries, menopause is not considered to have yet occurred. Following the removal of the uterus, symptoms typically occur earlier. In the years before menopause, a woman's periods typically become irregular, which means that periods may be longer or shorter in duration or be lighter or heavier in the amount of flow. During this time, women often experience hot flashes; these typically last from 30 seconds to ten minutes and may be associated with shivering, sweating, and reddening of the skin. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Post Menopausal
Menopause, also known as the climacteric, is the time in women's lives when menstrual periods stop permanently, and they are no longer able to bear children. Menopause usually occurs between the age of 47 and 54. Medical professionals often define menopause as having occurred when a woman has not had any menstrual bleeding for a year. It may also be defined by a decrease in hormone production by the ovaries. In those who have had surgery to remove their uterus but still have functioning ovaries, menopause is not considered to have yet occurred. Following the removal of the uterus, symptoms typically occur earlier. In the years before menopause, a woman's periods typically become irregular, which means that periods may be longer or shorter in duration or be lighter or heavier in the amount of flow. During this time, women often experience hot flashes; these typically last from 30 seconds to ten minutes and may be associated with shivering, sweating, and reddening of the skin. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sterility (physiology)
Sterility is the physiological inability to effect sexual reproduction in a living thing, members of whose kind have been produced sexually. Sterility has a wide range of causes. It may be an inherited trait, as in the mule; or it may be acquired from the environment, for example through physical injury or disease, or by exposure to radiation. Sterility is the inability to produce a biological child, while infertility is the inability to conceive after a certain period. Sterility is rarely discussed in clinical literature and is often used synonymously with infertility. Infertility affects about 12-15% of couples globally. Still, the prevalence of sterility remains unknown. Sterility can be divided into three subtypes natural, clinical, and hardship. Natural sterility is the couple’s physiological inability to conceive a child naturally. Clinical sterility is natural sterility for which treatment of the patient will not result in conception. Hardship sterility is the inability to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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