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Closed Testing Procedure
In statistics, the closed testing procedure is a general method for performing more than one hypothesis test simultaneously. The closed testing principle Suppose there are ''k'' hypotheses ''H''1,..., ''H''''k'' to be tested and the overall type I error rate is α. The closed testing principle allows the rejection of any one of these elementary hypotheses, say ''H''''i'', if all possible intersection hypotheses involving ''H''''i'' can be rejected by using valid local level α tests; the adjusted p-value is the largest among those hypotheses. It controls the family-wise error rate for all the ''k'' hypotheses at level α in the strong sense. Example Suppose there are three hypotheses ''H''1,''H''2, and ''H''3 to be tested and the overall type I error rate is 0.05. Then ''H''1 can be rejected at level α if ''H''1 ∩ ''H''2 ∩ ''H''3, ''H''1 ∩ ''H''2, ''H''1 ∩ ''H''3 and ''H''1 can all be rejected using valid tests with level α. Special cases The Holm–Bonferroni method ...
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Statistics
Statistics (from German: '' Statistik'', "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of surveys and experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey samples. Representative sampling assures that inferences and conclusions can reasonably extend from the sample to the population as a whole. An ...
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Statistical Hypothesis Testing
A statistical hypothesis test is a method of statistical inference used to decide whether the data at hand sufficiently support a particular hypothesis. Hypothesis testing allows us to make probabilistic statements about population parameters. History Early use While hypothesis testing was popularized early in the 20th century, early forms were used in the 1700s. The first use is credited to John Arbuthnot (1710), followed by Pierre-Simon Laplace (1770s), in analyzing the human sex ratio at birth; see . Modern origins and early controversy Modern significance testing is largely the product of Karl Pearson ( ''p''-value, Pearson's chi-squared test), William Sealy Gosset (Student's t-distribution), and Ronald Fisher ("null hypothesis", analysis of variance, " significance test"), while hypothesis testing was developed by Jerzy Neyman and Egon Pearson (son of Karl). Ronald Fisher began his life in statistics as a Bayesian (Zabell 1992), but Fisher soon grew disenchanted with ...
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Family-wise Error Rate
In statistics, family-wise error rate (FWER) is the probability of making one or more false discoveries, or type I errors when performing multiple hypotheses tests. Familywise and Experimentwise Error Rates Tukey (1953) developed the concept of a familywise error rate as the probability of making a Type I error among a specified group, or "family," of tests. Based on Tukey (1953), Ryan (1959) proposed the related concept of an ''experimentwise error rate'', which is the probability of making a Type I error in a given experiment. Hence, an experimentwise error rate is a familywise error rate for all of the tests that are conducted within an experiment. As Ryan (1959, Footnote 3) explained, an experiment may contain two or more families of multiple comparisons, each of which relates to a particular statistical inference and each of which has its own separate familywise error rate. Hence, familywise error rates are usually based on theoretically informative collections of multiple c ...
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Holm–Bonferroni Method
In statistics, the Holm–Bonferroni method, also called the Holm method or Bonferroni–Holm method, is used to counteract the problem of multiple comparisons. It is intended to control the family-wise error rate (FWER) and offers a simple test uniformly more powerful than the Bonferroni correction. It is named after Sture Holm, who codified the method, and Carlo Emilio Bonferroni. Motivation When considering several hypotheses, the problem of multiplicity arises: the more hypotheses are checked, the higher the probability of obtaining Type I errors (false positives). The Holm–Bonferroni method is one of many approaches for controlling the FWER, i.e., the probability that one or more Type I errors will occur, by adjusting the rejection criteria for each of the individual hypotheses. Formulation The method is as follows: * Suppose you have m p-values, sorted into order lowest-to-highest P_1,\ldots,P_m, and their corresponding hypotheses H_1,\ldots,H_m(null hypotheses). Yo ...
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Stat Med
'' Statistics in Medicine'' is a peer-reviewed statistics journal published by Wiley. Established in 1982, the journal publishes articles on medical statistics. The journal is indexed by ''Mathematical Reviews'' and SCOPUS. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 2.497. References External links * Mathematics journals Publications established in 1982 English-language journals Wiley (publisher) academic journals {{math-journal-stub ...
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Multiple Comparisons
In statistics, the multiple comparisons, multiplicity or multiple testing problem occurs when one considers a set of statistical inferences simultaneously or infers a subset of parameters selected based on the observed values. The more inferences are made, the more likely erroneous inferences become. Several statistical techniques have been developed to address that problem, typically by requiring a stricter significance threshold for individual comparisons, so as to compensate for the number of inferences being made. History The problem of multiple comparisons received increased attention in the 1950s with the work of statisticians such as Tukey and Scheffé. Over the ensuing decades, many procedures were developed to address the problem. In 1996, the first international conference on multiple comparison procedures took place in Israel. Definition Multiple comparisons arise when a statistical analysis involves multiple simultaneous statistical tests, each of which has a poten ...
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Bonferroni Correction
In statistics, the Bonferroni correction is a method to counteract the multiple comparisons problem. Background The method is named for its use of the Bonferroni inequalities. An extension of the method to confidence intervals was proposed by Olive Jean Dunn. Statistical hypothesis testing is based on rejecting the null hypothesis if the likelihood of the observed data under the null hypotheses is low. If multiple hypotheses are tested, the probability of observing a rare event increases, and therefore, the likelihood of incorrectly rejecting a null hypothesis (i.e., making a Type I error) increases. The Bonferroni correction compensates for that increase by testing each individual hypothesis at a significance level of \alpha/m, where \alpha is the desired overall alpha level and m is the number of hypotheses. For example, if a trial is testing m = 20 hypotheses with a desired \alpha = 0.05, then the Bonferroni correction would test each individual hypothesis at \alpha = 0.05/20 ...
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Statistical Tests
A statistical hypothesis test is a method of statistical inference used to decide whether the data at hand sufficiently support a particular hypothesis. Hypothesis testing allows us to make probabilistic statements about population parameters. History Early use While hypothesis testing was popularized early in the 20th century, early forms were used in the 1700s. The first use is credited to John Arbuthnot (1710), followed by Pierre-Simon Laplace (1770s), in analyzing the human sex ratio at birth; see . Modern origins and early controversy Modern significance testing is largely the product of Karl Pearson ( ''p''-value, Pearson's chi-squared test), William Sealy Gosset ( Student's t-distribution), and Ronald Fisher ("null hypothesis", analysis of variance, " significance test"), while hypothesis testing was developed by Jerzy Neyman and Egon Pearson (son of Karl). Ronald Fisher began his life in statistics as a Bayesian (Zabell 1992), but Fisher soon grew disenchanted wit ...
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