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Cell Survival Curve
A cell survival curve is a curve used in radiobiology. It depicts the relationship between the fraction of cells retaining their reproductive integrity and the absorbed dose of radiation. Conventionally, the surviving fraction is depicted on a logarithmic scale, and is plotted on the y-axis against dose on the x-axis. The linear quadratic model is now most often used to describe the cell survival curve, assuming that there are two mechanisms to cell death by radiation: A single lethal event or an accumulation of harmful but non-lethal events. Cell survival fractions are exponential functions with a dose-dependent term in the exponent due to the Poisson statistics underlying the stochastic process. Whereas single lethal events lead to an exponent that is linearly related to dose, the survival fraction function for a two-stage mechanism carries an exponent proportional to the square of dose. The coefficients must be inferred from measured data, such as the Hiroshima Leukemia data ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiobiology
Radiobiology (also known as radiation biology, and uncommonly as actinobiology) is a field of clinical and basic medical sciences that involves the study of the action of ionizing radiation on living things, especially health effects of radiation. Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Its most common impact is the induction of cancer with a latent period of years or decades after exposure. High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled doses are used for medical imaging and radiotherapy. Health effects In general, ionizing radiation is harmful and potentially lethal to living beings but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Most adverse health effects of radiation exposure may be grouped in two general categori ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (biology)
The cell is the basic structural and functional unit of life forms. Every cell consists of a cytoplasm enclosed within a membrane, and contains many biomolecules such as proteins, DNA and RNA, as well as many small molecules of nutrients and metabolites.Cell Movements and the Shaping of the Vertebrate Body in Chapter 21 of Molecular Biology of the Cell '' fourth edition, edited by Bruce Alberts (2002) published by Garland Science. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos. It is also common to describe small molecules such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Absorbed Dose
Absorbed dose is a dose quantity which is the measure of the energy deposited in matter by ionizing radiation per unit mass. Absorbed dose is used in the calculation of dose uptake in living tissue in both radiation protection (reduction of harmful effects), and radiology (potential beneficial effects for example in cancer treatment). It is also used to directly compare the effect of radiation on inanimate matter such as in radiation hardening. The SI unit of measure is the gray (Gy), which is defined as one Joule of energy absorbed per kilogram of matter. The older, non-SI CGS unit rad, is sometimes also used, predominantly in the USA. Deterministic effects Conventionally, in radiation protection, unmodified absorbed dose is only used for indicating the immediate health effects due to high levels of acute dose. These are tissue effects, such as in acute radiation syndrome, which are also known as deterministic effects. These are effects which are certain to happen in a short ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Logarithmic Scale
A logarithmic scale (or log scale) is a way of displaying numerical data over a very wide range of values in a compact way—typically the largest numbers in the data are hundreds or even thousands of times larger than the smallest numbers. Such a scale is nonlinear: the numbers 10 and 20, and 60 and 70, are not the same distance apart on a log scale. Rather, the numbers 10 and 100, and 60 and 600 are equally spaced. Thus moving a unit of distance along the scale means the number has been ''multiplied'' by 10 (or some other fixed factor). Often exponential growth curves are displayed on a log scale, otherwise they would increase too quickly to fit within a small graph. Another way to think about it is that the ''number of digits'' of the data grows at a constant rate. For example, the numbers 10, 100, 1000, and 10000 are equally spaced on a log scale, because their numbers of digits is going up by 1 each time: 2, 3, 4, and 5 digits. In this way, adding two digits ''multiplies'' the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiation-induced Cancer
Exposure to ionizing radiation is known to increase the future incidence of cancer, particularly leukemia. The mechanism by which this occurs is well understood, but quantitative models predicting the level of risk remain controversial. The most widely accepted model posits that the incidence of cancers due to ionizing radiation increases linearly with effective radiation dose at a rate of 5.5% per sievert; if correct, natural background radiation is the most hazardous source of radiation to general public health, followed by medical imaging as a close second. Additionally, the vast majority of non-invasive cancers are non-melanoma skin cancers caused by ultraviolet radiation (which lies on the boundary between ionizing and non-ionizing radiation). Non-ionizing radio frequency radiation from mobile phones, electric power transmission, and other similar sources have been investigated as a possible carcinogen by the WHO's International Agency for Research on Cancer, but to date, no e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poisson Distribution
In probability theory and statistics, the Poisson distribution is a discrete probability distribution that expresses the probability of a given number of events occurring in a fixed interval of time or space if these events occur with a known constant mean rate and Statistical independence, independently of the time since the last event. It is named after France, French mathematician Siméon Denis Poisson (; ). The Poisson distribution can also be used for the number of events in other specified interval types such as distance, area, or volume. For instance, a call center receives an average of 180 calls per hour, 24 hours a day. The calls are independent; receiving one does not change the probability of when the next one will arrive. The number of calls received during any minute has a Poisson probability distribution with mean 3: the most likely numbers are 2 and 3 but 1 and 4 are also likely and there is a small probability of it being as low as zero and a very smal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stochastic Process
In probability theory and related fields, a stochastic () or random process is a mathematical object usually defined as a family of random variables. Stochastic processes are widely used as mathematical models of systems and phenomena that appear to vary in a random manner. Examples include the growth of a bacterial population, an electrical current fluctuating due to thermal noise, or the movement of a gas molecule. Stochastic processes have applications in many disciplines such as biology, chemistry, ecology, neuroscience, physics, image processing, signal processing, control theory, information theory, computer science, cryptography and telecommunications. Furthermore, seemingly random changes in financial markets have motivated the extensive use of stochastic processes in finance. Applications and the study of phenomena have in turn inspired the proposal of new stochastic processes. Examples of such stochastic processes include the Wiener process or Brownian motion process, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dose Fractionation
Dose fractionation effects are utilised in the treatment of cancer with radiation therapy. When the total dose of radiation is divided into several, smaller doses over a period of several days, there are fewer toxic effects on healthy cells. This maximizes the effect of radiation on cancer and minimizes the negative side effects. A typical fractionation scheme divides the dose into 30 units delivered every weekday over six weeks. Hypofractionation is a treatment regimen that delivers higher doses of radiation in fewer visits, which tends to lower the effects of accelerated tumor growth that typically occurs during the later stages of radiotherapy. Hyperfractionation is dividing the same total dose into more deliveries, so that treatments are given more than once a day. Hyperfractionated radiation therapy is given over the same period of time (days or weeks) as standard radiation therapy. Accelerated fractionation (two deliveries per day and/or deliveries on weekends as well) has also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dose–response Relationship
The dose–response relationship, or exposure–response relationship, describes the magnitude of the response of an organism, as a function of exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time. Dose–response relationships can be described by dose–response curves. This is explained further in the following sections. A stimulus response function or stimulus response curve is defined more broadly as the response from any type of stimulus, not limited to chemicals. Motivation for studying dose–response relationships Studying dose response, and developing dose–response models, is central to determining "safe", "hazardous" and (where relevant) beneficial levels and dosages for drugs, pollutants, foods, and other substances to which humans or other organisms are exposed. These conclusions are often the basis for public policy. The U.S. Environmental Protection Agency has developed extensive guidance and reports on dose–respon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic Radiation Syndrome
Chronic radiation syndrome (CRS), or chronic radiation enteritis, is a constellation of health effects of radiation that occur after months or years of chronic exposure to high amounts of radiation. Chronic radiation syndrome develops with a speed and severity proportional to the radiation dose received (i.e., it is a deterministic effect of exposure to ionizing radiation), unlike radiation-induced cancer. It is distinct from acute radiation syndrome, in that it occurs at dose rates low enough to permit natural repair mechanisms to compete with the radiation damage during the exposure period. Dose rates high enough to cause the acute form (> ~0.1 Gy/h) are fatal long before onset of the chronic form. The lower threshold for chronic radiation syndrome is between 0.7 and 1.5 Gy, at dose rates above 0.1 Gy/yr. This condition is primarily known from the Kyshtym disaster, where 66 cases were diagnosed. It has received little mention in Western literature; but see the ICRP’s 2012 Stat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Curves
A curve is a geometrical object in mathematics. Curve(s) may also refer to: Arts, entertainment, and media Music * Curve (band), an English alternative rock music group * ''Curve'' (album), a 2012 album by Our Lady Peace * "Curve" (song), a 2017 song by Gucci Mane featuring The Weeknd * ''Curve'', a 2001 album by Doc Walker * "Curve", a song by John Petrucci from ''Suspended Animation'', 2005 * "Curve", a song by Cam'ron from the album '' Crime Pays'', 2009 Periodicals * ''Curve'' (design magazine), an industrial design magazine * ''Curve'' (magazine), a U.S. lesbian magazine Other uses in arts, entertainment, and media * ''Curve'' (film), a 2015 film * BBC Two 'Curve' idents, various animations based around a curve motif Brands and enterprises *Curve (payment card), a payment card that aggregates multiple payment cards * Curve (theatre), a theatre in Leicester, United Kingdom * Curve, fragrance by Liz Claiborne * BlackBerry Curve, a series of phones from Research in Motio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
