Chronic radiation syndrome (CRS), or chronic radiation enteritis,
is a constellation of
health effects of radiation that occur after months or years of chronic exposure to high amounts of radiation. Chronic radiation syndrome develops with a speed and severity proportional to the
radiation dose
Ionizing radiation (or ionising radiation), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them. Some particles can travel ...
received (i.e., it is a deterministic effect of exposure to
ionizing radiation
Ionizing radiation (or ionising radiation), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them. Some particles can travel ...
), unlike
radiation-induced cancer
Exposure to ionizing radiation is known to increase the future incidence of cancer, particularly leukemia. The mechanism by which this occurs is well understood, but quantitative models predicting the level of risk remain controversial. The most wi ...
. It is distinct from
acute radiation syndrome, in that it occurs at dose rates low enough to permit natural repair mechanisms to compete with the radiation damage during the exposure period. Dose rates high enough to cause the acute form (> ~0.1 Gy/h) are fatal long before onset of the chronic form. The lower threshold for chronic radiation syndrome is between 0.7 and 1.5
Gy, at dose rates above 0.1 Gy/yr.
This condition is primarily known from the
Kyshtym disaster
The Kyshtym disaster, sometimes referred to as the Mayak disaster or Ozyorsk disaster in newer sources, was a radioactive contamination accident that occurred on 29 September 1957 at Mayak, a plutonium production site for nuclear weapons and nu ...
, where 66 cases were diagnosed. It has received little mention in Western literature;
but see the ICRP’s 2012 Statement.
[ Compare the published draft () and note dose thresholds.
]
In 2013, Alexander V. Akleyev described the chronology of the clinical course of CRS while presenting at ConRad in
Munich, Germany
Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the third-largest city in Germany, after Berlin and Ha ...
. In his presentation, he defined the latent period as being 1-5 years, and the formation coinciding with the period of maximum radiation dose. The recovery period was described as being 3-12 months after exposure ceased. He concluded that "CRS represents a systemic response of the body as a whole to the chronic total body exposure in man." In 2014, Akleyev's book "Comprehensive analysis of chronic radiation syndrome, covering epidemiology, pathogenesis, pathoanatomy, diagnosis and treatment" was published by
Springer
Springer or springers may refer to:
Publishers
* Springer Science+Business Media, aka Springer International Publishing, a worldwide publishing group founded in 1842 in Germany formerly known as Springer-Verlag.
** Springer Nature, a multinationa ...
.
Symptoms of chronic radiation syndrome would include, at an early stage, impaired sense of touch and smell and disturbances of the vegetative functions. At a later stage, muscle and skin atrophy and eye cataract follow, with possible fibrous formations on the skin, in case of previous radiation burns. Solid cancer or
leukemia
Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...
due to genetic damage may appear at any time.
References
{{reflist
Radiation health effects