|
Carole LaBonne
Carole LaBonne is a Developmental and Stem Cell Biologist at Northwestern University. She is the Erastus O. Haven Professor of Life Sciences, and Chair of the Department of Molecular Biosciences. Education and early career LaBonne received her bachelor's degree from the University of Rochester, doing research with Sayeeda Zain on the molecular basis of Alzheimer's disease. Inspired by the work of famed embryologist and Rochester emeritus professor Johannes Holtfreter, LaBonne pursued doctoral work at Harvard University studying germ layer formation using ''Xenopus'' as a model. As a National Science Foundation pre-doctoral Fellow working with Malcolm Whitman, LaBonne characterized the role of FGF signaling in formation of the mesendoderm. During her doctoral study, LaBonne discovered that activin-mediated mesoderm induction required FGF signaling and elucidated the role of RAS-Map Kinase signaling in this process. Following her graduate work, LaBonne pursued post-doctoral ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Rochester
The University of Rochester (U of R, UR, or U of Rochester) is a private university, private research university in Rochester, New York. The university grants Undergraduate education, undergraduate and graduate degrees, including Doctorate, doctoral and professional degrees. The University of Rochester enrolls approximately 6,800 undergraduates and 5,000 graduate students. Its 158 buildings house over 200 academic majors. According to the National Science Foundation, Rochester spent more than $397 million on research and development in 2020, ranking it 66th in the nation. With approximately 28,000 full-time employees, the university is the largest private employer in Upstate New York and the 7th largest in all of New York (state), New York State. The University of Rochester College of Arts Sciences and Engineering, College of Arts, Sciences, and Engineering is home to departments and divisions of note. The Institute of Optics was founded in 1929 through a grant from Eastm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SNAI2
Zinc finger protein SNAI2 is a transcription factor that in humans is encoded by the ''SNAI2'' gene. It promotes the differentiation and migration of certain cells and has roles in initiating gastrulation. Function This gene encodes a member of the Snail superfamily of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcription (genetics), transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has apoptosis, antiapoptotic activity. It regulates differentiation and migration of neural crest cells along with other genes (e.g. FOXD3, SOX9 and SOX10, Bone morphogenetic protein, BMPs) in embryonic life. Mutations in this gene may be associated with sporadic cases of neural tube neural tube defects, defects. SNAI2 downregulates expression of E-cadherin in premigratory neural crest cells; thus, SNAI2 induces tightly b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Weinberg College Of Arts And Sciences
Northwestern University is a private research university in Evanston, Illinois. Founded in 1851, Northwestern is the oldest chartered university in Illinois and is ranked among the most prestigious academic institutions in the world. Chartered by the Illinois General Assembly in 1851, Northwestern was established to serve the former Northwest Territory. The university was initially affiliated with the Methodist Episcopal Church but later became non-sectarian. By 1900, the university was the third largest university in the United States. In 1896, Northwestern became a founding member of the Big Ten Conference, and joined the Association of American Universities as an early member in 1917. The university is composed of eleven undergraduate, graduate, and professional schools, which include the Kellogg School of Management, the Pritzker School of Law, the Feinberg School of Medicine, the Weinberg College of Arts and Sciences, the Bienen School of Music, the McCormick School o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne McLaren
Dame Anne Laura Dorinthea McLaren, (26 April 1927 – 7 July 2007) was a British scientist who was a leading figure in developmental biology. Her work helped lead to human in vitro fertilisation (IVF),''The Telegraph'' obituary for Prof. Dame Anne McLaren 9 July 2007 and she received many honours for her contributions to science, including election as fellow of the . Early life McLaren was the daughter of SirHenry McLaren, 2nd Baron Aberconw ...
[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histone Deacetylase
Histone deacetylases (, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins. HDAC super family Together with the acetylpolyamine amidohydrolases and the acetoin utilization proteins, the histone deacetylases form an ancient protein superfamily known as the histone deacetylase superfamily. Classes of HDACs in higher eukaryotes HDACs, are classified in four classes depending on sequence homology to the yeast original enzymes and domain organization: HDAC (except class III) contain zinc and are known as Zn2+-dependent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetics
In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, but the term can also be used to describe any heritable phenotypic change. Such effects on cellular and physiological phenotypic traits may result from external or environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Gene express ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endoderm
Endoderm is the innermost of the three primary germ layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer). Cells migrating inward along the archenteron form the inner layer of the gastrula, which develops into the endoderm. The endoderm consists at first of flattened cells, which subsequently become columnar. It forms the epithelial lining of multiple systems. In plant biology, endoderm corresponds to the innermost part of the cortex (bark) in young shoots and young roots often consisting of a single cell layer. As the plant becomes older, more endoderm will lignify. Production The following chart shows the tissues produced by the endoderm. The embryonic endoderm develops into the interior linings of two tubes in the body, the digestive and respiratory tube. Liver and pancreas cells are believed to derive from a common precursor. In humans, the endoderm can differentiate into distinguishable organs after 5 wee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pluripotent
Pluripotency: These are the cells that can generate into any of the three Germ layers which imply Endodermal, Mesodermal, and Ectodermal cells except tissues like the placenta. According to Latin terms, Pluripotentia means the ability for many things. We can generate Induced Pluripotent cells by using the Induced pluripotency technique by triggering or expressing the genes or the transcription factors of the normal somatic cells. They are abbreviated as iPSC or IPS. We can forcefully express the transcription factors like Oct4, Sox2, Klf4, and c- Myc of a non-pluripotent cell and convert them into a stem cell. This procedure is first studied in a Mouse fibroblast cell in 2006 and followed the same instructions in developing a Human pluripotent cell from a Human epidermal fibroblast cell. The technique is called Regeneration. Though the iPSC has similar properties to embryonic stem cells they were never approved for clinical stage research because they are highly Tumerogenic, h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ID3 (gene)
DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ''ID3'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b .... Function Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA. upplied by OMIMref name="entrez" /> Interactions ID3 (gene) has been shown to interact with TCF3. Repressors of ID3 BTG2 binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons. See also * Inhibitor of DNA-binding protein References Further reading * * * * * * * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yamanaka Factors
is a Japanese stem cell researcher and a Nobel Prize laureate. He serves as the director of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyoto University; as a senior investigator at the UCSF-affiliated Gladstone Institutes in San Francisco, California; and as a professor of anatomy at University of California, San Francisco (UCSF). Yamanaka is also a past president of the International Society for Stem Cell Research (ISSCR). He received the 2010 BBVA Foundation Frontiers of Knowledge Award in the biomedicine category, the 2011 Wolf Prize in Medicine with Rudolf Jaenisch, and the 2012 Millennium Technology Prize together with Linus Torvalds. In 2012, he and John Gurdon were awarded the Nobel Prize for Physiology or Medicine for the discovery that mature cells can be converted to stem cells. In 2013, he was awarded the $3 million Breakthrough Prize in Life Sciences for hi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ontogeny
Ontogeny (also ontogenesis) is the origination and development of an organism (both physical and psychological, e.g., moral development), usually from the time of fertilization of the egg to adult. The term can also be used to refer to the study of the entirety of an organism's lifespan. Ontogeny is the developmental history of an organism within its own lifetime, as distinct from phylogeny, which refers to the evolutionary history of a species. Another way to think of ontogeny is that it is the process of an organism going through all of the developmental stages over its lifetime. The developmental history includes all the developmental events that occur during the existence of an organism, beginning with the changes in the egg at the time of fertilization and events from the time of birth or hatching and afterward (i.e., growth, remolding of body shape, development of secondary sexual characteristics, etc.). While developmental (i.e., ontogenetic) processes can influence ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marine Biological Laboratory
The Marine Biological Laboratory (MBL) is an international center for research and education in biological and environmental science. Founded in Woods Hole, Massachusetts, in 1888, the MBL is a private, nonprofit institution that was independent for most of its history, but became officially affiliated with the University of Chicago on July 1, 2013. It also collaborates with numerous other institutions. As of 2022, 60 Nobel Prize winners have been affiliated with MBL as students, faculty members or researchers. In addition since 1960, there have been, 137 Howard Hughes Medical Institute investigators, early career scientists, international researchers, and professors; 306 members of the National Academy of Sciences; and 236 Members of the American Academy of Arts and Sciences who have been affiliated with the lab. History 19th century The Marine Biological Laboratory grew from the vision of several Bostonians and Spencer Fullerton Baird, the United States' first Fish Commiss ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
