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Carmen Birchmeier-Kohler
Carmen Birchmeier-Kohler (born July 6, 1955, in Waldshut-Tiengen) is a German geneticist and developmental biologist. The focus of her research group is the development of embryonic tissues and the nervous system. The model organism for her investigations is the mouse. Life and work Birchmeier-Kohler studied biochemistry at the University of Konstanz, the University of California, San Diego and the ETH Zurich from 1974 to 1979. She completed her PhD thesis with Max Birnstiel in 1984 at the Institute of Molecular Biology II at the University of Zurich. After a stay abroad as a postdoctoral fellow with Michael Wigler and as a scientist at the Cold Spring Harbor Laboratory on Long Island (USA) from 1984 to 1989, she took over the direction of a working group in the Max Planck Institute for Plant Breeding Research in Cologne. There she completed her habilitation in 1993. Since 1995 she works at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin. In 2002 she received ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Waldshut-Tiengen
Waldshut-Tiengen (; gsw, label= Alemannic, Waldshuet-Düenge, italic=no), commonly known as Waldshut, is a city in southwestern Baden-Württemberg right at the Swiss border. It is the district seat and at the same time the biggest city in Waldshut district and a "middle centre" in the area of the "high centre" Lörrach/ Weil am Rhein to whose middle area most towns and communities in Waldshut district belong (with the exception of seven communities that belong to Bad Säckingen's area). There are furthermore complexities arising from cross-border traffic between this area and the Swiss cantons of Aargau, Schaffhausen and Zürich. This classification relates to Walter Christaller's Central Place Theory, however, and not to any official administrative scheme. The city, which was newly created in the framework of the 1975 municipal reform, at that time passed the 20,000 mark in population. City council then applied to have the city raised to '' Große Kreisstadt'', which the gover ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Freie Universität Berlin
The Free University of Berlin (, often abbreviated as FU Berlin or simply FU) is a public research university in Berlin, Germany. It is consistently ranked among Germany's best universities, with particular strengths in political science and the humanities. It is recognised as a leading university in international university rankings. The Free University of Berlin was founded in West Berlin in 1948 with American support during the early Cold War period as a Western continuation of the Friedrich Wilhelm University, or the University of Berlin, whose traditions and faculty members it retained. The Friedrich Wilhelm University (which was renamed the Humboldt University), being in East Berlin, faced strong communist repression; the Free University's name referred to West Berlin's status as part of the Western Free World, in contrast to communist-controlled East Berlin. In 2008, as part of a joint effort, the Free University of Berlin, along with the Hertie School of Governanc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
German Biochemists
German(s) may refer to: * Germany (of or related to) **Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Germanic peoples (Roman times) * German language **any of the Germanic languages * German cuisine, traditional foods of Germany People * German (given name) * German (surname) * Germán, a Spanish name Places * German (parish), Isle of Man * German, Albania, or Gërmej * German, Bulgaria * German, Iran * German, North Macedonia * German, New York, U.S. * Agios Germanos, Greece Other uses * German (mythology), a South Slavic mythological being * Germans (band), a Canadian rock band * "German" (song), a 2019 song by No Money Enterprise * ''The German'', a 2008 short film * "The Germans", an episode of ''Fawlty Towers'' * ''The German'', a nickname for Congolese rebel André Kisase Ngandu See also * Germanic (other) * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Of Sciences Leopoldina
The German National Academy of Sciences Leopoldina (german: Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften), short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on January 1, 1652, based on academic models in Italy, it was originally named the ''Academia Naturae Curiosorum'' until 1687 when Emperor Leopold I raised it to an academy and named it after himself. It was since known under the German name ''Deutsche Akademie der Naturforscher Leopoldina'' until 2007, when it was declared to be Germany's National Academy of Sciences. History ' The Leopoldina was founded in the imperial city of Schweinfurt on 1 January 1652 under the Latin name sometimes translated into English as "Academy of the Curious as to Nature." It was founded by four local physicians- Johann Laurentius Bausch, the first president of the society, Johann Michael Fehr, Georg Balthasar Metzger, and Georg Balthasar Wohlfarth; and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academia Europaea
The Academia Europaea is a pan-European Academy of Humanities, Letters, Law, and Sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of European interests in national research agencies. History The concept of a 'European Academy of Sciences' was raised at a meeting in Paris of the European Ministers of Science in 1985. The initiative was taken by the Royal Society (United Kingdom) which resulted in a meeting in London in June 1986 of Arnold Burgen (United Kingdom), Hubert Curien (France), Umberto Colombo (Italy), David Magnusson (Sweden), Eugen Seibold (Germany) and Ruurd van Lieshout (the Netherlands) – who agreed to the need for a new body. The two key purposes of Academia Europaea are: * express ideas and opinions of individual scientists from Europe * act as co-ordinator of European interests in national research agencies It does not aim to replace existing national ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response. Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. The changes elicited by ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a signaling pathway. When signaling pathways interact with one another they form networks, which allow cellular responses to be coordinated, often by combinatorial signaling events. At the molecular level, such responses include changes in the transcription or translation of genes, and post-translational and conformational changes in proteins, as well as changes in their location. These molecular events are the basic mechanisms controlling cell gro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gottfried Wilhelm Leibniz Prize
The Gottfried Wilhelm Leibniz Prize (german: link=no, Förderpreis für deutsche Wissenschaftler im Gottfried Wilhelm Leibniz-Programm der Deutschen Forschungsgemeinschaft), in short Leibniz Prize, is awarded by the German Research Foundation to "exceptional scientists and academics for their outstanding achievements in the field of research". Since 1986, up to ten prizes are awarded annually to individuals or research groups working at a research institution in Germany or at a German research institution abroad. It is considered the most important research award in Germany. The prize is named after the German polymath and philosopher Gottfried Wilhelm Leibniz (1646–1716). It is one of the highest endowed research prizes in Germany with a maximum of €2.5 million per award. Past prize winners include Stefan Hell (2008), Gerd Faltings (1996), Peter Gruss (1994), Svante Pääbo (1992), Theodor W. Hänsch (1989), Erwin Neher (1987), Bert Sakmann (1987), Jürgen Habermas (198 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription Factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the desired cells at the right time and in the right amount throughout the life of the cell and the organism. Groups of TFs function in a coordinated fashion to direct cell division, cell growth, and cell death throughout life; cell migration and organization ( body plan) during embryonic development; and intermittently in response to signals from outside the cell, such as a hormone. There are up to 1600 TFs in the human genome. Transcription factors are members of the proteome as well as regulome. TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor (biochemistry)
In biochemistry and pharmacology, receptors are chemical structures, composed of protein, that receive and transduce signals that may be integrated into biological systems. These signals are typically chemical messengers which bind to a receptor and cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. There are three main ways the action of the receptor can be classified: relay of signal, amplification, or integration. Relaying sends the signal onward, amplification increases the effect of a single ligand, and integration allows the signal to be incorporated into another biochemical pathway. Receptor proteins can be classified by their location. Transmembrane receptors include ligand-gated ion channels, G protein-coupled receptors, and enzyme-linked hormone receptors. Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors. A molecule that binds to a receptor is called a ligan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Growth Factor
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. Usually it is a secreted protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells. They often promote cell differentiation and maturation, which varies between growth factors. For example, epidermal growth factor (EGF) enhances osteogenic differentiation, while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation (angiogenesis). Comparison to cytokines ''Growth factor'' is sometimes used interchangeably among scientists with the term ''cytokine.'' Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune syste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Knockout Mice
A knockout mouse, or knock-out mouse, is a genetically modified mouse (''Mus musculus'') in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are important animal models for studying the role of genes which have been sequenced but whose functions have not been determined. By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function. Mice are currently the laboratory animal species most closely related to humans for which the knockout technique can easily be applied. They are widely used in knockout experiments, especially those investigating genetic questions that relate to human physiology. Gene knockout in rats is much harder and has only been possible since 2003. The first recorded knockout mouse was created by Mario R. Capecchi, Martin Evans, and Oliver Smithies in 1989, for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organogenesis
Organogenesis is the phase of embryonic development that starts at the end of gastrulation and continues until birth. During organogenesis, the three germ layers formed from gastrulation (the ectoderm, endoderm, and mesoderm) form the internal organs of the organism. The cells of each of the three germ layers undergo differentiation, a process where less-specialized cells become more-specialized through the expression of a specific set of genes. Cell differentiation is driven by cell signaling cascades. Differentiation is influenced by extracellular signals such as growth factors that are exchanged to adjacent cells which is called juxtracrine signaling or to neighboring cells over short distances which is called paracrine signaling. Intracellular signals consist of a cell signaling itself ( autocrine signaling), also play a role in organ formation. These signaling pathways allow for cell rearrangement and ensure that organs form at specific sites within the organism. The organ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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