Carmen Birchmeier-Kohler (born July 6, 1955, in

Waldshut-Tiengen Waldshut-Tiengen (; gsw, label= Alemannic, Waldshuet-Düenge, italic=no), commonly known as Waldshut, is a city in southwestern Baden-Württemberg right at the Swiss border. It is the district seat and at the same time the biggest city in Waldsh ...

) is a German

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processes ...

and

developmental biologist Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem c ...

. The focus of her research group is the development of embryonic tissues and the

nervous system In biology, the nervous system is the highly complex part of an animal that coordinates its actions and sensory information by transmitting signals to and from different parts of its body. The nervous system detects environmental changes ...

. The model organism for her investigations is the mouse.

Life and work

Birchmeier-Kohler studied

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

at the

University of Konstanz The University of Konstanz (german: Universität Konstanz) is a university in the city of Konstanz in Baden-Württemberg, Germany. Its main campus was opened on the Gießberg in 1972 after being founded in 1966. The university is Germany's ...

, the

University of California, San Diego The University of California, San Diego (UC San Diego or colloquially, UCSD) is a public land-grant research university in San Diego, California. Established in 1960 near the pre-existing Scripps Institution of Oceanography, UC San Diego is t ...

and the ETH Zurich from 1974 to 1979. She completed her PhD thesis with

Max Birnstiel Max Luciano Birnstiel (12 July 1933 – 15 November 2014) was a Swiss molecular biologist who held a number of positions in scientific leadership in Europe, including the chair of the Institute of Molecular Biology at the University of Zurich from ...

in 1984 at the Institute of Molecular Biology II at the

University of Zurich The University of Zürich (UZH, german: Universität Zürich) is a public research university located in the city of Zürich, Switzerland. It is the largest university in Switzerland, with its 28,000 enrolled students. It was founded in 1833 f ...

. After a stay abroad as a postdoctoral fellow with

Michael Wigler Michael Howard Wigler (born September 3, 1947, in New York) is an American molecular biologist who has directed a laboratory at Cold Spring Harbor Laboratory since 1978 and is a member of the National Academy of Sciences. He is best known for d ...

and as a scientist at the

Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory (CSHL) is a private, non-profit institution with research programs focusing on cancer, neuroscience, plant biology, genomics, and quantitative biology. It is one of 68 institutions supported by the Cancer Centers ...

on Long Island (USA) from 1984 to 1989, she took over the direction of a working group in the

Max Planck Institute for Plant Breeding Research The Max Planck Institute for Plant Breeding Research was founded in Müncheberg, Germany in 1928 as part of the Kaiser-Wilhelm-Gesellschaft. The founding director, Erwin Baur, initiated breeding programmes with fruits and berries, and basic resear ...

in Cologne. There she completed her habilitation in 1993. Since 1995 she works at the

Max Delbrück Center for Molecular Medicine Max or MAX may refer to: Animals * Max (dog) (1983–2013), at one time purported to be the world's oldest living dog * Max (English Springer Spaniel), the first pet dog to win the PDSA Order of Merit (animal equivalent of OBE) * Max (gorilla) ...

(MDC) in Berlin. In 2002 she received a C4-professorship at the Faculty of Medicine of

Freie Universität Berlin The Free University of Berlin (, often abbreviated as FU Berlin or simply FU) is a public research university in Berlin, Germany. It is consistently ranked among Germany's best universities, with particular strengths in political science and t ...

, now Charité. Carmen Birchmeier is married to developmental biologist and cancer researcher Walter Birchmeier.

Research interests

Birchmeier-Kohler is concerned with the molecular biology of embryogenesis and

organogenesis Organogenesis is the phase of embryonic development that starts at the end of gastrulation and continues until birth. During organogenesis, the three germ layers formed from gastrulation (the ectoderm, endoderm, and mesoderm) form the internal org ...

in mammals and their significance for abnormal development of the nervous system, in skeletal muscle and heart diseases as well as in cancer. With the help of knockout mice, Birchmeier-Kohler and co-workers were able to elucidate the role of various

growth factor A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. Usually it is a secreted protein or a steroid hormone. Growth factors are important for regul ...

s or their

receptors Receptor may refer to: *Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ...

and the

transcription factor In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...

s they control for the development of the organism.

Awards and honors

In 2002 she was awarded the Gottfried Wilhelm Leibniz Prize for her research on signal transduction between cells during embryonic and organ development of mammals.

Memberships (selection)

Since 2013 she is a member of the

Academia Europaea The Academia Europaea is a pan-European Academy of Humanities, Letters, Law, and Sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europea ...

. In 2018 she was elected a member of the German

Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (german: Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften), short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded ...

.Prof. Dr. Carmen Birchmeier
at the Leopoldina.

External links

Website of Carmen Birchmeier-Kohler's group

Press release of the MDC on receiving the Leibniz prize

References

{{DEFAULTSORT:Birchmeier-Kohler, Carmen German biochemists German women biochemists Living people 1955 births Members of the German National Academy of Sciences Leopoldina Members of Academia Europaea