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Camurati–Engelmann Disease
Camurati–Engelmann disease (CED) is a very rare autosomal dominant genetic disorder that causes characteristic anomalies in the skeleton. It is also known as progressive diaphyseal dysplasia. It is a form of dysplasia. Patients typically have heavily thickened bones, especially along the shafts of the long bones (called diaphyseal dysplasia). The skull bones may be thickened so that the passages through the skull that carry nerves and blood vessels become narrowed, possibly leading to sensory deficits, blindness, or deafness. This disease often appears in childhood and is considered to be inherited, however many patients have no previous history of CED within their family. The disease is slowly progressive and, while there is no cure, there is treatment. It is named for M. Camurati and G. Engelmann. Signs and symptoms Patients with CED complain of chronic bone pain in the legs or arms, muscle weakness (myopathy) and experience a waddling gait. Other clinical problems associate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autosomal Dominant
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and the second recessive. This state of having two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new (''de novo'') or inherited. The terms autosomal dominant or autosomal recessive are used to describe gene variants on non-sex chromosomes ( autosomes) and their associated traits, while those on sex chromosomes (allosomes) are termed X-linked dominant, X-linked recessive or Y-linked; these have an inheritance and presentation pattern that depends on the sex of both the parent and the child (see Sex linkage). Since there is only one copy of the Y chromosome, Y-linked traits cannot be dominant or recessive. Additionally, there are other forms of dominance such as incomplete d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tibia
The tibia (; ), also known as the shinbone or shankbone, is the larger, stronger, and anterior (frontal) of the two bones in the leg below the knee in vertebrates (the other being the fibula, behind and to the outside of the tibia); it connects the knee with the ankle. The tibia is found on the medial side of the leg next to the fibula and closer to the median plane. The tibia is connected to the fibula by the interosseous membrane of leg, forming a type of fibrous joint called a syndesmosis with very little movement. The tibia is named for the flute ''tibia''. It is the second largest bone in the human body, after the femur. The leg bones are the strongest long bones as they support the rest of the body. Structure In human anatomy, the tibia is the second largest bone next to the femur. As in other vertebrates the tibia is one of two bones in the lower leg, the other being the fibula, and is a component of the knee and ankle joints. The ossification or formation of the bone ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Skeletal Disorders
Bone disease refers to the medical conditions which affect the bone. Terminology A bone disease is also called an "osteopathy", but because the term osteopathy is often used to refer to an alternative health-care philosophy, use of the term can cause some confusion. Bone and cartilage disorders Osteochondrodysplasia is a general term for a disorder of the development of bone and cartilage. List A * Ambe * Avascular necrosis or Osteonecrosis * Arthritis B * Bone spur (Osteophytes) C * Craniosynostosis * Coffin–Lowry syndrome * Copenhagen disease F * Fibrodysplasia ossificans progressiva * Fibrous dysplasia * Fong disease (or Nail–patella syndrome) * Fracture G * Giant cell tumor of bone * Greenstick fracture * Gout H * Hypophosphatasia * Hereditary multiple exostoses K * Klippel–Feil syndrome M * Metabolic bone disease * Multiple myeloma N * Nail–patella syndrome O * Osteitis * Osteitis deformans (or Paget's disease of bone) * Osteitis fibr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extracellular Ligand Disorders
This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms. It is intended as introductory material for novices; for more specific and technical definitions from sub-disciplines and related fields, see Glossary of genetics, Glossary of evolutionary biology, Glossary of ecology, and Glossary of scientific naming, or any of the organism-specific glossaries in :Glossaries of biology. A B C D E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ghost Whisperer
''Ghost Whisperer'' is an American supernatural television series, which ran on CBS from September 23, 2005, to May 21, 2010. The series follows the life of Melinda Gordon ( Jennifer Love Hewitt), who has the ability to see and communicate with ghosts. While trying to live as normal a life as possible—she is married and owns an antique store—Melinda helps earthbound spirits resolve their problems and cross over into the light, or the spirit world. Her tasks are difficult and at times she struggles with people who push her away and do not believe in her gift. In addition, the ghosts are mysterious and sometimes menacing at first, and Melinda must use the clues available to her to understand the spirits' needs and help them. The show was created by John Gray and was produced by Sander/Moses Productions, executive producer, and Jennifer Love Hewitt in association with ABC Studios and CBS Television Studios. On May 18, 2010, CBS canceled the series after five seasons. Premise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John Belluso
John Belluso (November 13, 1969 – February 10, 2006) was an American playwright best known for his works focusing on the lives of disabled people. He also directed a writing program for disabled people. Early life and education Born in Warwick, Rhode Island, he began using a wheelchair at the age of 13 due to a bone disease, Camurati-Engelmann syndrome. He completed both Bachelors and Masters degrees at New York University's Tisch School of the Arts Dramatic Writing program. Career In 2001, he wrote ''The Body of Bourne'', based on the life of Randolph Bourne, a World War I pacifist and author. It was produced in Los Angeles by the Mark Taper Forum. He also directed the Forum's Other Voices program for writers with a disability. After that, he wrote ''Pyretown'', which criticises America's managed care health system through a romance between a divorced mother and a young, wheelchair-using man. Belluso joined the crew of the HBO western drama '' Deadwood'' as a writer f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Winter
Winter is the coldest season of the year in polar and temperate climates. It occurs after autumn and before spring. The tilt of Earth's axis causes seasons; winter occurs when a hemisphere is oriented away from the Sun. Different cultures define different dates as the start of winter, and some use a definition based on weather. When it is winter in the Northern Hemisphere, it is summer in the Southern Hemisphere, and vice versa. In many regions, winter brings snow and freezing temperatures. The moment of winter solstice is when the Sun's elevation with respect to the North or South Pole is at its most negative value; that is, the Sun is at its farthest below the horizon as measured from the pole. The day on which this occurs has the shortest day and the longest night, with day length increasing and night length decreasing as the season progresses after the solstice. The earliest sunset and latest sunrise dates outside the polar regions differ from the date of the winte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glucocorticosteroid
Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebrate animal cell. The name "glucocorticoid" is a portmanteau (glucose + cortex + steroid) and is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure (see structure below). Glucocorticoids are part of the feedback mechanism in the immune system, which reduces certain aspects of immune function, such as inflammation. They are therefore used in medicine to treat diseases caused by an overactive immune system, such as allergies, asthma, autoimmune diseases, and sepsis. Glucocorticoids have many diverse (pleiotropic) effects, including potentially harmful side effects. They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spleen
The spleen is an organ found in almost all vertebrates. Similar in structure to a large lymph node, it acts primarily as a blood filter. The word spleen comes .σπλήν Henry George Liddell, Robert Scott, ''A Greek-English Lexicon'', on Perseus Digital Library The spleen plays very important roles in regard to s (erythrocytes) and the . It removes old red blood cells and holds a reserve of blood, which can be valuable in case of |
Liver
The liver is a major Organ (anatomy), organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of proteins and biochemicals necessary for digestion and growth. In humans, it is located in the quadrant (anatomy), right upper quadrant of the abdomen, below the thoracic diaphragm, diaphragm. Its other roles in metabolism include the regulation of Glycogen, glycogen storage, decomposition of red blood cells, and the production of hormones. The liver is an accessory digestive organ that produces bile, an alkaline fluid containing cholesterol and bile acids, which helps the fatty acid degradation, breakdown of fat. The gallbladder, a small pouch that sits just under the liver, stores bile produced by the liver which is later moved to the small intestine to complete digestion. The liver's highly specialized biological tissue, tissue, consisting mostly of hepatocytes, regulates a w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Osteosclerosis
Osteosclerosis is a disorder that is characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone. Plain radiographs are a valuable tool for detecting and classifying osteosclerotic disorders. It can manifest in localized or generalized osteosclerosis. Localized osteosclerosis can be caused by Legg–Calvé–Perthes disease, sickle-cell disease and osteoarthritis among others. Osteosclerosis can be classified in accordance with the causative factor into acquired and hereditary. Types Acquired osteosclerosis * Osteogenic bone metastasis caused by carcinoma of prostate and breast * Paget's disease of bone * Myelofibrosis (primary disorder or secondary to intoxication or malignancy) * Osteosclerosing types of chronic osteomyelitis * Hypervitaminosis D * hyperparathyroidism * Schnitzler syndrome * Mastocytosis Skeletal fluorosis * Monoclonal IgM Kappa cryoglobulinemia * Hepatitis C. Heredita ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
