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CLNS1A
Methylosome subunit pICln is a protein that in humans is encoded by the ''CLNS1A'' gene. Interactions CLNS1A has been shown to interact with: * ITGA2B, * PRMT5, * SNRPD1, and * SNRPD3. See also * Chloride channel Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration ''in vivo'' is much higher than other anions. Several ... References Further reading * * * * * * * * * * * * * * * External links * * Ion channels {{gene-11-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Arginine Methyltransferase 5
Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the ''PRMT5'' gene. PRMT5 symmetrically dimethylates H2AR3, H4R3, H3R2, and H3R8 in vivo, all of which are linked to a range of transcriptional regulatory events. PRMT5 is a highly conserved arginine methyltransferase that translocated from the cytoplasm to the nucleus at embryonic day ~E8.5, and during preimplantation development at the ~4-cell stage. Model organisms Model organisms have been used in the study of PRMT5 function. A conditional knockout mouse line, called ''Prmt5tm2a(EUCOMM)Wtsi'' was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on mutant mice and two significant abnormalities were observed. No homozy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ITGA2B
Integrin alpha-IIb is a protein that in humans is encoded by the ''ITGA2B'' gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Interactions ITGA2B has been shown to interact with AUP1 and CLNS1A. See also * Cluster of differentiation * Glycoprotein IIb/IIIa In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and vo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Nuclear Ribonucleoprotein D1
Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the ''SNRPD1'' gene. Function This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Interactions Small nuclear ribonucleoprotein D1 has been shown to interact with: * CDC5L, * CLNS1A, * DDX20, * SMN1, and * Small nuclear ribonucleoprotein D2 Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the ''SNRPD2'' gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein b ... References Further reading * * * * * * * * * * * * * * * * * * {{Ribonucleoproteins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SNRPD3
Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the ''SNRPD3'' gene. Function The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Interactions SNRPD3 has been shown to interact with: * CDC5L, * CLNS1A, * DDX20, and * Protein arginine methyltransferase 5 Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the ''PRMT5'' gene. PRMT5 symmetrically dimethylates H2AR3, H4R3, H3R2, and H3R8 in vivo, all of which are linked to a range of transcriptional regulatory events. PR .... References Further reading * * * * * * * * * * * * * * * * * * {{Gene-22-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Juri Rappsilber
Juri Rappsilber (born 1971) is a German chemist in the area of mass spectrometry and proteomics. Career Rappsilber studied chemistry at the Technical University of Berlin, University of Strathclyde, and with Tom Rapoport, Harvard Medical School. In 2001, he earned his Ph.D. in Proteomics jointly from EMBL Heidelberg and the Goethe University Frankfurt working in the laboratory of Matthias Mann on the mass spectrometric analysis of protein complexes, externally supervised by Michael Karas. He followed Mann to the University of Southern Denmark and completed a postdoctoral fellowship before starting his independent career at IFOM - FIRC Institute for Molecular Oncology, Milan in 2003. In 2006, he joined the Wellcome Trust Centre for Cell Biology in the Institute of Cell Biology at the University of Edinburgh. In 2009, he became a senior research fellow of the Wellcome Trust, in 2010 he was appointed Professor of Proteomics in Edinburgh. Since 2011, he has been Full Professor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloride Channel
Chloride channels are a superfamily of poorly understood ion channels specific for chloride. These channels may conduct many different ions, but are named for chloride because its concentration ''in vivo'' is much higher than other anions. Several families of voltage-gated channels and ligand-gated channels (e.g., the CaCC families) have been characterized in humans. Voltage-gated chloride channels display a variety of important physiological and cellular roles that include regulation of pH, volume homeostasis, organic solute transport, cell migration, cell proliferation and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups. General functions Voltage-gated chloride channels are important for setting cell resting membrane potential and maintaining proper cell volume. These channels conduct or other anions such as . The structure of these channels are not like other known channels. The chloride channel subunits contain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
