Juri Rappsilber (born 1971) is a German

chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...

in the area of

mass spectrometry Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a ''mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is use ...

and proteomics.

Career

Rappsilber studied chemistry at the Technical University of Berlin,

University of Strathclyde The University of Strathclyde ( gd, Oilthigh Shrath Chluaidh) is a public research university located in Glasgow, Scotland. Founded in 1796 as the Andersonian Institute, it is Glasgow's second-oldest university, having received its royal chart ...

, and with

Tom Rapoport Tom Abraham Rapoport (born June 17, 1947) is a German-American cell biologist who studies protein transport in cells. Currently, he is a professor at Harvard Medical School and a Howard Hughes Medical Institute investigator. Born in Cincinnati, OH ...

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

. In 2001, he earned his

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is ...

in Proteomics jointly from EMBL Heidelberg and the

Goethe University Frankfurt Goethe University (german: link=no, Johann Wolfgang Goethe-Universität Frankfurt am Main) is a university located in Frankfurt am Main, Germany. It was founded in 1914 as a citizens' university, which means it was founded and funded by the wealt ...

working in the laboratory of Matthias Mann on the mass spectrometric analysis of protein complexes, externally supervised by Michael Karas. He followed Mann to the

University of Southern Denmark The University of Southern Denmark ( da, Syddansk Universitet, lit=South Danish University, abbr. SDU) is a university in Denmark that has campuses located in Southern Denmark and on Zealand. The university offers a number of joint programmes in ...

and completed a

postdoctoral A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

fellowship before starting his independent career at IFOM - FIRC Institute for Molecular Oncology,

Milan Milan ( , , Lombard: ; it, Milano ) is a city in northern Italy, capital of Lombardy, and the second-most populous city proper in Italy after Rome. The city proper has a population of about 1.4 million, while its metropolitan city h ...

in 2003. In 2006, he joined the

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...

Centre for Cell Biology in the Institute of Cell Biology at the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...

. In 2009, he became a senior research fellow of the Wellcome Trust, in 2010 he was appointed Professor of Proteomics in Edinburgh. Since 2011, he has been

Full Professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professors ...

and head of the Chair of Bioanalytics at the Technical University of Berlin.

Research

Rappsilber’s interests are focused on combining chemistry and

computer science Computer science is the study of computation, automation, and information. Computer science spans theoretical disciplines (such as algorithms, theory of computation, information theory, and automation) to Applied science, practical discipli ...

with biological mass spectrometry to expand the current knowledge on how cells work. His lab is working on novel methods for identifying and quantifying the interactions and the accurate sites of interaction of

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

s with other proteins, DNA and

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

. As a central tool they have pioneered crosslinking mass spectrometry. Technologically, they bridge

organic chemistry Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...

nucleotide Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules wi ...

chemistry,

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

, separation sciences, mass spectrometry,

data visualisation Data and information visualization (data viz or info viz) is an interdisciplinary field that deals with the graphic representation of data and information. It is a particularly efficient way of communicating when the data or information is nu ...

, programming and

machine learning Machine learning (ML) is a field of inquiry devoted to understanding and building methods that 'learn', that is, methods that leverage data to improve performance on some set of tasks. It is seen as a part of artificial intelligence. Machine ...

. Their vision is to reveal the dynamic structure and interactions of every protein in a cell, in a time-resolved manner.

Awards

* 2021 Elected

EMBO Member Membership of the European Molecular Biology Organization (EMBO) is an award granted by the European Molecular Biology Organization (EMBO) in recognition of "research excellence and the outstanding achievements made by a life scientist". , 88 EMB ...

* 2009 Senior Research Fellow of the Wellcome Trust * 2005 Marie Curie Excellence Fellow * 2001 Marie Curie Fellow

References

External links

* *
Website
at

Unifying Systems in Catalysis The Cluster of Excellence Unifying Systems in Catalysis (UniSysCat) is an interdisciplinary research network funded by the German Research Foundation (DFG) as part of the federal and state excellence strategy of Germany (Exzellenzstrategie). ...

(UniSysCat) {{DEFAULTSORT:Rappsilber, Juri Academics of the University of Edinburgh Technical University of Berlin faculty Technical University of Berlin alumni Goethe University Frankfurt alumni German chemists German biochemists Mass spectrometrists Living people 1971 births Members of the European Molecular Biology Organization