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CLDN15
Claudin-15 is a protein that in humans is encoded by the ''CLDN15'' gene. It belongs to the group of claudins. Among its related pathways are Blood–brain barrier, Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signal transduction, Signaling Pathways and Tight junction. GO annotations related to this gene include ''identical protein binding'' and ''structural molecule activity''. An important paralog of this gene is CLDN10. References External links * Further reading * * * * * * * * * * * * {{protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Claudin
Claudins are a family of proteins which, along with occludin, are the most important components of the tight junctions ( zonulae occludentes). Tight junctions establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Structure Claudins are small (20–24/27 kilodalton (kDa)) transmembrane proteins which are found in many organisms, ranging from nematodes to human beings. They all have a very similar structure. Claudins span the cellular membrane 4 times, with the N-terminal end and the C-terminal end both located in the cytoplasm, and two extracellular loops which show the highest degree of conservation. Claudins have both cis and trans interactions between cell membranes. Cis-interactions is when claudins on the same membrane interact, one way they interact is by transmembrane domain having molecular intera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
