Soviet Biological Weapons Program
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Soviet Biological Weapons Program
The Soviet Union covertly operated the world's largest, longest, and most sophisticated biological weapons program, thereby violating its obligations as a party to the 1972 Biological Weapons Convention.Leitenberg, M., Zilinskas, R., & Kuhn, J. (2012). Conclusion. In ''The Soviet Biological Weapons Program'' (pp. 698-712). Cambridge, Massachusetts; London, England: Harvard University Press. Retrieved February 7, 2021, from http://www.jstor.org/stable/j.ctt2jbscf.30 The program began in the 1920s and lasted until at least September 1992 but has possibly been continued by Russia after that. During World War II, Joseph Stalin was forced to move his biological warfare (BW) operations out of the way of advancing German forces and may have used tularemia against German troops in 1942 near Stalingrad. By 1960, numerous BW research facilities existed throughout the Soviet Union. Although the USSR also signed the 1972 Biological Weapons Convention (BWC), the Soviets subsequently augment ...
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Soviet Union
The Soviet Union,. officially the Union of Soviet Socialist Republics. (USSR),. was a transcontinental country that spanned much of Eurasia from 1922 to 1991. A flagship communist state, it was nominally a federal union of fifteen national republics; in practice, both its government and its economy were highly centralized until its final years. It was a one-party state governed by the Communist Party of the Soviet Union, with the city of Moscow serving as its capital as well as that of its largest and most populous republic: the Russian SFSR. Other major cities included Leningrad (Russian SFSR), Kiev (Ukrainian SSR), Minsk ( Byelorussian SSR), Tashkent (Uzbek SSR), Alma-Ata (Kazakh SSR), and Novosibirsk (Russian SFSR). It was the largest country in the world, covering over and spanning eleven time zones. The country's roots lay in the October Revolution of 1917, when the Bolsheviks, under the leadership of Vladimir Lenin, overthrew the Russian Provisional Government ...
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Brucellosis
Brucellosis is a highly contagious zoonosis caused by ingestion of unpasteurized milk or undercooked meat from infected animals, or close contact with their secretions. It is also known as undulant fever, Malta fever, and Mediterranean fever. The bacteria causing this disease, ''Brucella'', are small, Gram-negative, nonmotile, nonspore-forming, rod-shaped ( coccobacilli) bacteria. They function as facultative intracellular parasites, causing chronic disease, which usually persists for life. Four species infect humans: ''B. abortus'', ''B. canis'', ''B. melitensis'', and ''B. suis''. ''B. abortus'' is less virulent than ''B. melitensis'' and is primarily a disease of cattle. ''B. canis'' affects dogs. ''B. melitensis'' is the most virulent and invasive species; it usually infects goats and occasionally sheep. ''B. suis'' is of intermediate virulence and chiefly infects pigs. Symptoms include profuse sweating and joint and muscle pain. Brucellosis has been recognized in animals and ...
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Kanatjan Alibekov
Kanatzhan "Kanat" Alibekov ( kk, Қанатжан Байзақұлы Әлібеков, Qanatjan Baizaqūly Älıbekov; russian: Канатжан Алибеков, Kanatzhan Alibekov; born 1950), known as Kenneth "Ken" Alibek since 1992, is a Kazakhstani-American microbiologist, and biological warfare (BW) administrative management expert. He rose rapidly in the ranks of the Soviet Army to become the First Deputy Director of Biopreparat, with a rank of Colonel, during which time he claimed to oversee a vast program of 40 BW facilities with 32,000 employees. During his career as a Soviet bioweaponeer, in the late 1970s and 1980s, Alibekov managed projects that included weaponizing glanders and Marburg hemorrhagic fever, and created Russia's first tularemia bomb. Jacobsen, Annie (2015), ''The Pentagon's Brain: An Uncensored History of DARPA, America's Top Secret Military Research Agency''; New York: Little, Brown and Company, pg 293. His most prominent accomplishment was the cre ...
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Vladimir Pasechnik
Vladimir Artemovich Pasechnik (12 October 1937 Stalingrad, USSR – 21 November 2001, Wiltshire, England) was a senior Soviet biologist and bioweaponeer who defected to the United Kingdom in 1989, alerting Western intelligence to the vast scope of Moscow's clandestine biological warfare (BW) programme, known as Biopreparat. His revelations that the program was ten times larger than previously suspected were confirmed in 1992 with the defection to the United States of Colonel Kanatjan Alibekov, the No. 2 scientist for the program. Biography A native of Leningrad, many members of Pasechnik's family, including his parents, perished in the Nazi siege of that city during World War II. Pasechnik studied at the Leningrad Polytechnical Institute, where he was one of the institute's brightest stars, graduating at the top of his class. Pasechnik initially specialised in the study of polymers for biological uses at the Institute of High Molecular Compounds in Leningrad. The intent was ...
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Sverdlovsk Anthrax Leak
On 2 April 1979, spores of '' Bacillus anthracis'' (the causative agent of anthrax) were accidentally released from a Soviet military research facility in the city of Sverdlovsk, Soviet Union (now Yekaterinburg, Russia). The ensuing outbreak of the disease resulted in the deaths of at least 66 people, although the exact number of victims remains unknown. The cause of the outbreak was denied for years by the Soviet authorities, which blamed the deaths on consumption of tainted meat from the area, and subcutaneous exposure due to butchers handling the tainted meat. The accident was the first major indication in the Western world that the Soviet Union had embarked upon an offensive programme aimed at the development and large-scale production of biological weapons. Background Sverdlovsk had been a major production center of the Soviet military-industrial complex since World War II. By the 1970s, 87 per cent of the city's industrial production was military; only 13 per cent fo ...
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Boris Yeltsin
Boris Nikolayevich Yeltsin ( rus, Борис Николаевич Ельцин, p=bɐˈrʲis nʲɪkɐˈla(j)ɪvʲɪtɕ ˈjelʲtsɨn, a=Ru-Boris Nikolayevich Yeltsin.ogg; 1 February 1931 – 23 April 2007) was a Soviet and Russian politician who served as the first president of the Russian Federation from 1991 to 1999. He was a member of the Communist Party of the Soviet Union from 1961 to 1990. He later stood as a Political Independent, political independent, during which time he was viewed as being ideologically aligned with liberalism and Russian nationalism. Yeltsin was born in Butka, Russia, Butka, Ural Oblast. He grew up in Kazan and Berezniki. After studying at the Ural State Technical University, he worked in construction. After joining the Communist Party, he rose through its ranks, and in 1976 he became First Secretary of the party's Sverdlovsk Oblast committee. Yeltsin was initially a supporter of the ''perestroika'' reforms of Soviet leader Mikhail Gorbachev. He lat ...
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Smallpox
Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making it the only human disease to be eradicated. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash. Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was spread between people or via contaminated objects. Prevention was achieved mainly through the smallpox vaccine. Once the disease had developed, certain antiviral medication may have helped. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their ...
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Orthopoxvirus
''Orthopoxvirus'' is a genus of viruses in the family ''Poxviridae'' and subfamily ''Chordopoxvirinae''. Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. Diseases associated with this genus include smallpox, cowpox, horsepox, camelpox, and monkeypox. The most widely known member of the genus is '' Variola virus'', which causes smallpox. It was eradicated globally by 1977, through the use of ''Vaccinia virus'' as a vaccine. The most recently described species is the ''Alaskapox virus'', first isolated in 2015. Microbiology Structure Orthopoxviruses are enveloped with brick-shaped geometries and virion dimensions around 200 nm wide and 250 nm long. Genome Member viruses have linear DNA genomes around 170–250 kb in length. Lifecycle Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs), which mediate cellula ...
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Marburg Virus
Marburg virus (MARV) is a hemorrhagic fever virus of the ''Filoviridae'' family of viruses and a member of the species '' Marburg marburgvirus'', genus ''Marburgvirus''. It causes Marburg virus disease in primates, a form of viral hemorrhagic fever. The virus is considered to be extremely dangerous. The World Health Organization (WHO) rates it as a Risk Group 4 Pathogen (requiring biosafety level 4-equivalent containment). In the United States, the National Institute of Allergy and Infectious Diseases ranks it as a Category A Priority Pathogen and the Centers for Disease Control and Prevention lists it as a Category A Bioterrorism Agent. It is also listed as a biological agent for export control by the Australia Group. The virus can be transmitted by exposure to one species of fruit bats or it can be transmitted between people via body fluids through unprotected sex and broken skin. The disease can cause haemorrhage, fever, and other symptoms similar to Ebola, which belongs t ...
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Smallpox
Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making it the only human disease to be eradicated. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash. Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was spread between people or via contaminated objects. Prevention was achieved mainly through the smallpox vaccine. Once the disease had developed, certain antiviral medication may have helped. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their ...
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Staphylococcal Enterotoxin B
In the field of molecular biology, enterotoxin type B, also known as Staphylococcal enterotoxin B (SEB), is an enterotoxin produced by the gram-positive bacteria ''Staphylococcus aureus''. It is a common cause of food poisoning, with severe diarrhea, nausea and intestinal cramping often starting within a few hours of ingestion. Being quite stable, the toxin may remain active even after the contaminating bacteria are killed. It can withstand boiling at 100 °C for a few minutes. Gastroenteritis occurs because SEB is a superantigen, causing the immune system to release a large amount of cytokines that lead to significant inflammation. Additionally, this protein is one of the causative agents of toxic shock syndrome. Function The function of this protein is to facilitate the infection of the host organism. It is a virulence factor designed to induce pathogenesis. One of the major virulence exotoxins is the toxic shock syndrome toxin (TSST), which is secreted by the organis ...
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Botulinum Toxin
Botulinum toxin, or botulinum neurotoxin (BoNT), is a neurotoxic protein produced by the bacterium ''Clostridium botulinum'' and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. The toxin causes the disease botulism. The toxin is also used commercially for medical and cosmetic purposes. The seven main types of botulinum toxin are named types A to G (A, B, C1, C2, D, E, F and G). New types are occasionally found. Types A and B are capable of causing disease in humans, and are also used commercially and medically. Types C–G are less common; types E and F can cause disease in humans, while the other types cause disease in other animals. Botulinum toxins are among the most potent toxins known. Intoxication can occur naturally as a result of either wound or intestinal infection or by ingesting formed toxin in food. The estimated human lethal dose of type A toxin is 1.3 ...
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