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Curare Poisoning
Curare ( /kʊˈrɑːri/ or /kjʊˈrɑːri/; ''koo-rah-ree'' or ''kyoo-rah-ree'') is a common name for various alkaloid arrow poisons originating from plant extracts. Used as a paralyzing agent by indigenous peoples in Central and South America for hunting and for therapeutic purposes, curare only becomes active when it contaminates a wound. These poisons cause weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm. Curare is prepared by boiling the bark of one of the dozens of plant sources, leaving a dark, heavy paste that can be applied to arrow or dart heads. In medicine, curare has been used as a treatment for tetanus or strychnine poisoning and as a paralyzing agent for surgical procedures. History The word 'curare' is derived from ''wurari'', from the Carib language of the Macusi of Guyana. It has its origins in the Carib phrase "mawa cure" meaning of the Mawa vine, scien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acacia Tetragonophylla
''Acacia tetragonophylla'', commonly known as curara, kurara or dead finish, is a tree in the family Fabaceae that is endemic to arid and semi-arid parts of central and western Australia. Description Curara grows as a tall shrub or small tree up to a height of and has an intricate and often straggly habit with glabrous branchlets. Like most ''Acacia'' species, it has phyllodes rather than true leaves. These are slender and needle-like with a length of up and a width of . When young they are soft and pliable, but as they mature they become hard, rigid and very sharp. The glabrous phyllodes are formed in groups of two to six on dwarf, knotty and lateral branchlets or singly on new shoots. The phyllodes have a slender linear shape ending in a sharp point and are mostly pentagonal to compressed in cross-section with five to seven prominent nerves. In Western Australia it blooms between May and October producing yellow flowers. The flowers are yellow, and held in spherical clusters. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lesser Antilles
The Lesser Antilles ( es, link=no, Antillas Menores; french: link=no, Petites Antilles; pap, Antias Menor; nl, Kleine Antillen) are a group of islands in the Caribbean Sea. Most of them are part of a long, partially volcanic island arc between the Greater Antilles to the north-west and the continent of South America."West Indies." ''Merriam-Webster's Geographical Dictionary'', 3rd ed. 2001. () Springfield, MA: Merriam-Webster Inc., p. 1298. The islands of the Lesser Antilles form the eastern boundary of the Caribbean Sea where it meets the Atlantic Ocean. Together, the Lesser Antilles and the Greater Antilles make up the Antilles. (Somewhat confusingly, the word Caribbean is sometimes used to refer only to the Antilles, and sometimes used to refer to a much larger region.) The Lesser and Greater Antilles, together with the Lucayan Archipelago, are collectively known as the West Indies. History after European arrival The Spanish were the first Europeans to arrive on the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Island Caribs
The Kalinago, also known as the Island Caribs or simply Caribs, are an indigenous people of the Lesser Antilles in the Caribbean. They may have been related to the Mainland Caribs (Kalina) of South America, but they spoke an unrelated language known as Island Carib. They also spoke a pidgin language associated with the Mainland Caribs. At the time of Spanish contact, the Kalinago were one of the dominant groups in the Caribbean, which owes its name to them. They lived throughout northeastern South America, Trinidad and Tobago, Barbados, the Windward Islands, Dominica, and possibly the southern Leeward Islands. Historically, it was thought their ancestors were mainland peoples who had conquered the islands from their previous inhabitants, the Igneri. However, linguistic and archaeological evidence contradicts the notion of a mass emigration and conquest; the Kalinago language appears not to have been Cariban, but like that of their neighbors, the Taíno. Irving Rouse and o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blowgun
A blowgun (also called a blowpipe or blow tube) is a simple ranged weapon consisting of a long narrow tube for shooting light projectiles such as darts. It operates by having the projectile placed inside the pipe and using the force created by forced exhalation ("blow") to pneumatically propel the projectile. The propulsive power is limited by the strength of the user's respiratory muscles and the vital capacity of their lungs. History Many cultures have used such a weapon, but various indigenous peoples of Eastern Asia, Southeast Asia, Western Europe, North America, Central America (the Huehuetenango region of Guatemala), and South America (the Amazon Basin and the Guianas) are best known for its historical usage. Projectiles include seeds, clay pellets, and darts. Some cultures dip the tip of the darts in curare or other arrow poisons in order to paralyze the target. Blowguns were very rarely used by these tribes as anti-personnel weapons, but primarily to hunt small ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of California, Los Angeles
The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California State Normal School (now San José State University). This school was absorbed with the official founding of UCLA as the Southern Branch of the University of California in 1919, making it the second-oldest of the 10-campus University of California system (after UC Berkeley). UCLA offers 337 undergraduate and graduate degree programs in a wide range of disciplines, enrolling about 31,600 undergraduate and 14,300 graduate and professional students. UCLA received 174,914 undergraduate applications for Fall 2022, including transfers, making the school the most applied-to university in the United States. The university is organized into the College of Letters and Science and 12 professional schools. Six of the schools offer undergraduate degre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxiferine
Toxiferine (C-toxiferine I) is a curare toxin. It is a bisindole alkaloid derived from ''Strychnos toxifera'' and a nicotinic acetylcholine receptor antagonist. This alkaloid is the main toxic component of Calabash curare, and one of the most toxic plant alkaloids known. The lethal dose (LD50) for mice has been determined as 10 - 60 µg/kg by intravenous administration. It is a muscle relaxant that causes paralysis of skeletal muscle, which takes approximately 2 hours to recovery for a moderate dose, and 8 hours of total paralysis with a 20-fold paralytic dose. The paralysis can be antagonized by neostigmine Neostigmine, sold under the brand name Bloxiverz, among others, is a medication used to treat myasthenia gravis, Ogilvie syndrome, and urinary retention without the presence of a blockage. It is also used in anaesthesia to end the effects of n ... References Indole alkaloids Nicotinic antagonists Quaternary ammonium compounds Neuromuscular blockers Neurotox ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calabash
Calabash (; ''Lagenaria siceraria''), also known as bottle gourd, white-flowered gourd, long melon, birdhouse gourd, New Guinea bean, Tasmania bean, and opo squash, is a vine grown for its fruit. It can be either harvested young to be consumed as a vegetable, or harvested mature to be dried and used as a utensil, container, or a musical instrument. When it is fresh, the fruit has a light green smooth skin and white flesh. Calabash fruits have a variety of shapes: they can be huge and rounded, small and bottle-shaped, or slim and serpentine, and they can grow to be over a metre long. Rounder varieties are typically called calabash gourds. The gourd was one of the world's first cultivated plants grown not primarily for food, but for use as containers. The bottle gourd may have been carried from Asia to Africa, Europe, and the Americas in the course of human migration, or by seeds floating across the oceans inside the gourd. It has been proven to have been globally domesticated (an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Crescentia Cujete
''Crescentia cujete'', commonly known as the calabash tree, is a species of flowering plant native to the Americas, that is grown in Africa, Central America, South America, the West Indies and extreme southern Florida. It is the national tree of St. Lucia. It is a dicotyledonous plant with simple leaves, which are alternate or in fascicles (clusters) on short shoots. It is naturalized in India. The tree shares its common name with that of the vine calabash, or bottle gourd (''Lagenaria siceraria''). In Cuba, this tree is known to grow in both disturbed habitat and areas of poor drainage. It can grow up to 10 meters tall. Uses Caribbean A calabash is primarily used to make utensils such as cups, bowls, and basins in rural areas. It can be used for carrying water, or for transporting fish, when fishing. In some Caribbean countries, it is worked, painted, and decorated and turned into items by artisans, and sold to tourists. As a cup, bowl, or even a water-pipe or "bong", the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Terra Cotta
Terracotta, terra cotta, or terra-cotta (; ; ), in its material sense as an earthenware substrate, is a clay-based unglazed or glazed ceramic where the fired body is porous. In applied art, craft, construction, and architecture, terracotta is the term normally used for sculpture made in earthenware and also for various practical uses, including vessels (notably flower pots), water and waste water pipes, roofing tiles, bricks, and surface embellishment in building construction. The term is also used to refer to the natural brownish orange color of most terracotta. In archaeology and art history, "terracotta" is often used to describe objects such as figurines not made on a potter's wheel. Vessels and other objects that are or might be made on a wheel from the same material are called earthenware pottery; the choice of term depends on the type of object rather than the material or firing technique. Unglazed pieces, and those made for building construction and industry, are ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Loganiaceae
The Loganiaceae are a family of flowering plants classified in order Gentianales. The family includes up to 13 genera, distributed around the world's tropics. There are not any great morphological characteristics to distinguish these taxa from others in the order Gentianales. Many members of the Loganiaceae are extremely poisonous, causing death by convulsion. Poisonous properties are largely due to alkaloids such as those found in ''Strychnos''. Glycosides are also present as loganin in ''Strychnos''.Flowering Plants of the World by consultant editor Vernon H. Heywood, 1978, Oxford University Press, Walton Street, Oxford OX2 6DP, England, Earlier treatments of the family have included up to 29 genera. Phylogenetic studies have demonstrated that this broadly defined Loganiaceae was a polyphyletic assemblage, and numerous genera have been removed from Loganiaceae to other families (sometimes in other orders), e.g., Gentianaceae, Gelsemiaceae, Plocospermataceae, Tetrachondrac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Median Lethal Dose
In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a toxin, radiation, or pathogen. The value of LD50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD50 is indicative of increased toxicity. The test was created by J.W. Trevan in 1927. The term semilethal dose is occasionally used in the same sense, in particular with translations of foreign language text, but can also refer to a sublethal dose. LD50 is usually determined by tests on animals such as laboratory mice. In 2011, the U.S. Food and Drug Administration approved alternative methods to LD50 for testing the cosmetic drug Botox without animal tests. Conventions The LD50 is usually expressed as the mass of substance administered per unit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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