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Cubosomes
Cubosomes are discrete, sub-micron, nanostructured particles of the bicontinuous cubic liquid crystalline phase. The term "bicontinuous" refers to two distinct hydrophilic regions separated by the bilayer. Bicontinuous cubic crystalline materials have been an active research topic because their structure lends itself well to controlled-release applications. Cubosomes are liquid crystalline nano-structures formed from the cubic phase of lipids, such as monooleate, or any other amphiphilic macromolecules with the unique property to be dispersed into particles. Nano-vehicles are generated from a self-assembled lipid mixture and studied by means of high-resolution cryogenic transmission electron microscope (cryo-TEM). These structures have been observed to naturally occur in mitochondrial membranes and in stressed cells. Cubosomes are formed at controlled temperatures into lipid bi-layer twisted into three dimension with minimal surface forming a tightly packed structure with bic ...
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Liquid Crystal
Liquid crystal (LC) is a state of matter whose properties are between those of conventional liquids and those of solid crystals. For example, a liquid crystal may flow like a liquid, but its molecules may be oriented in a crystal-like way. There are many types of LC phases, which can be distinguished by their optical properties (such as textures). The contrasting textures arise due to molecules within one area of material ("domain") being oriented in the same direction but different areas having different orientations. LC materials may not always be in a LC state of matter (just as water may be ice or water vapor). Liquid crystals can be divided into 3 main types: * thermotropic, *lyotropic, and * metallotropic. Thermotropic and lyotropic liquid crystals consist mostly of organic molecules, although a few minerals are also known. Thermotropic LCs exhibit a phase transition into the LC phase as temperature changes. Lyotropic LCs exhibit phase transitions as a function of b ...
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Hydrophile
A hydrophile is a molecule or other molecular entity that is attracted to water molecules and tends to be dissolved by water.Liddell, H.G. & Scott, R. (1940). ''A Greek-English Lexicon'' Oxford: Clarendon Press. In contrast, hydrophobes are not attracted to water and may seem to be repelled by it. Hygroscopics ''are'' attracted to water, but are not dissolved by water. Molecules A hydrophilic molecule or portion of a molecule is one whose interactions with water and other polar substances are more thermodynamically favorable than their interactions with oil or other hydrophobic solvents. They are typically charge-polarized and capable of hydrogen bonding. This makes these molecules soluble not only in water but also in other polar solvents. Hydrophilic molecules (and portions of molecules) can be contrasted with hydrophobic molecules (and portions of molecules). In some cases, both hydrophilic and hydrophobic properties occur in a single molecule. An example of these amphiph ...
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Transmission Electron Microscope
Transmission electron microscopy (TEM) is a microscopy technique in which a beam of electrons is transmitted through a specimen to form an image. The specimen is most often an ultrathin section less than 100 nm thick or a suspension on a grid. An image is formed from the interaction of the electrons with the sample as the beam is transmitted through the specimen. The image is then magnified and focused onto an imaging device, such as a fluorescent screen, a layer of photographic film, or a sensor such as a scintillator attached to a charge-coupled device. Transmission electron microscopes are capable of imaging at a significantly higher resolution than light microscopes, owing to the smaller de Broglie wavelength of electrons. This enables the instrument to capture fine detail—even as small as a single column of atoms, which is thousands of times smaller than a resolvable object seen in a light microscope. Transmission electron microscopy is a major analytical method in ...
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Mitochondrial Membrane
A mitochondrion (; ) is an organelle found in the cells of most Eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects. The term ''mitochondrion'' was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase coined by Philip Siekevitz in a 1957 article of the same name. Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells). A large number of unicellular organisms, such as microsporidia, parabasalids and diplomonads, have reduced or transformed their mitochondria into other structures. One eukaryote, ''Monocercomonoides'', is known to have completely lost its mitochondria, and one multicellular organism, '' Henn ...
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Gyroid
A gyroid is an infinitely connected Triply periodic minimal surface, triply periodic minimal surface discovered by Alan Schoen in 1970. History and properties The gyroid is the unique non-trivial embedded member of the associate family of the Schwarz minimal surface#Schwarz P .28.22Primitive.22.29, Schwarz P and Schwarz minimal surface#Schwarz D .28.22Diamond.22.29, D surfaces. Its angle of association with respect to the D surface is approximately 38.01°. The gyroid is similar to the lidinoid. The gyroid was discovered in 1970 by NASA scientist Alan Schoen. He calculated the angle of association and gave a convincing demonstration of pictures of intricate plastic models, but did not provide a proof of embeddedness. Schoen noted that the gyroid contains neither straight lines nor planar symmetries. Karcher gave a different, more contemporary treatment of the surface in 1989 using conjugate surface construction. In 1996 Große-Brauckmann and Wohlgemuth proved that it is embed ...
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Biodegradability
Biodegradation is the breakdown of organic matter by microorganisms, such as bacteria and fungi. It is generally assumed to be a natural process, which differentiates it from composting. Composting is a human-driven process in which biodegradation occurs under a specific set of circumstances. The process of biodegradation is threefold: first an object undergoes biodeterioration, which is the mechanical weakening of its structure; then follows biofragmentation, which is the breakdown of materials by microorganisms; and finally assimilation, which is the incorporation of the old material into new cells. In practice, almost all chemical compounds and materials are subject to biodegradation, the key element being time. Things like vegetables may degrade within days, while glass and some plastics take many millennia to decompose. A standard for biodegradability used by the European Union is that greater than 90% of the original material must be converted into , water and minerals by ...
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Liquid Crystals
Liquid crystal (LC) is a state of matter whose properties are between those of conventional liquids and those of solid crystals. For example, a liquid crystal may flow like a liquid, but its molecules may be oriented in a crystal-like way. There are many types of LC phases, which can be distinguished by their optical properties (such as textures). The contrasting textures arise due to molecules within one area of material ("domain") being oriented in the same direction but different areas having different orientations. LC materials may not always be in a LC state of matter (just as water may be ice or water vapor). Liquid crystals can be divided into 3 main types: * thermotropic, *lyotropic, and * metallotropic. Thermotropic and lyotropic liquid crystals consist mostly of organic molecules, although a few minerals are also known. Thermotropic LCs exhibit a phase transition into the LC phase as temperature changes. Lyotropic LCs exhibit phase transitions as a function of bo ...
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