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Coumarins
Coumarin () or 2''H''-chromen-2-one is an aromatic organic chemical compound with formula . Its molecule can be described as a benzene molecule with two adjacent hydrogen atoms replaced by a lactone-like chain , forming a second six-membered heterocycle that shares two carbons with the benzene ring. It can be placed in the benzopyrone chemical class and considered as a lactone. Coumarin is a colorless crystalline solid with a sweet odor resembling the scent of vanilla and a bitter taste. It is found in many plants, where it may serve as a chemical defense against predators. By inhibiting synthesis of vitamin K, a related compound is used as the prescription drug warfarin – an anticoagulant – to inhibit formation of blood clots, deep vein thrombosis, and pulmonary embolism. Etymology Coumarin is derived from ''coumarou'', the French word for the tonka bean. The word ''tonka'' for the tonka bean is taken from the Galibi (Carib) tongue spoken by natives of French Guia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Warfarin
Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). It is commonly used to prevent blood clots such as deep vein thrombosis and pulmonary embolism, and to prevent stroke in people who have atrial fibrillation, valvular heart disease, or artificial heart valves. Less commonly, it is used following ST-segment elevation myocardial infarction and orthopedic surgery. It is generally taken by mouth, but may also be used intravenously. The common side effect is bleeding. Less common side effects may include areas of tissue damage and purple toes syndrome. Use is not recommended during pregnancy. The effects of warfarin typically should be monitored by checking prothrombin time (INR) every one to four weeks. Many other medications and dietary factors can interact with warfarin, either increasing or decreasing its effectiveness. The effects of warfarin may be reversed with phytomenadione (vitamin K1), fresh f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticoagulant
Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, heart–lung machines, and dialysis equipment. One of the first anticoagulants, warfarin, was initially approved as a rodenticide. Anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation. Specifically, antiplatelet drugs inhibit platelet agg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitamin K
Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation (K from ''Koagulation'', German for "coagulation") or for controlling binding of calcium in bones and other tissues. The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor. Vitamin K is used in the liver as the intermediate VKH2 to deprotonate a glutamate residue and then is reprocessed into vitamin K through a vitamin K oxide intermediate. The presence of uncarboxylated proteins indicates a vitamin K deficiency. Carboxylation allows them to bind (chelate) calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs. Research suggests that deficiency of v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fougère
''Fougère'', , is one of the main olfactive families of perfumes. The name comes from the French language word for "fern". ''Fougère'' perfumes are made with a blend of fragrances: top-notes are sweet, with the scent of lavender flowers; as the more volatile components evaporate, the scents of oakmoss, derived from a species of lichen and described as woody, sharp and slightly sweet, and coumarin, similar to the scent of new-mown hay, become noticeable. Aromatic ''fougère'', a derivative of this class, contains additional notes of herbs, spice and/or wood. The name originated with Houbigant Parfum's ''Fougère Royale''. This perfume, created by Houbigant owner Paul Parquet, was later added to the scent archives known as the Osmothèque, in Versailles, France. Houbigant re-introduced this fragrance in 2010. Perfumes of this type are especially popular as fragrances for men. Many modern fougère perfumes have various citrus, herbaceous, green, floral and animalic notes in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Henry Perkin
Sir William Henry Perkin (12 March 1838 – 14 July 1907) was a British chemist and entrepreneur best known for his serendipitous discovery of the first commercial synthetic organic dye, mauveine, made from aniline. Though he failed in trying to synthesise quinine for the treatment of malaria, he became successful in the field of dyes after his first discovery at the age of 18. Perkin set up a factory to produce the dye industrially. Lee Blaszczyk, professor of business history at the University of Leeds, states, "By laying the foundation for the synthetic organic chemicals industry, Perkin helped to revolutionize the world of fashion." Early years William Perkin was born in the East End of London, the youngest of the seven children of George Perkin, a successful carpenter. His mother, Sarah, was of Scottish descent and moved to East London as a child.UXL Encyclopedia of World Biography (2003). Accessed 18 March 2008. He was baptized in the Anglican parish church of St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Académie Nationale De Médecine
Situated at 16 Rue Bonaparte in the 6th arrondissement of Paris, the Académie nationale de médecine (National Academy of Medicine) was created in 1820 by King Louis XVIII at the urging of baron Antoine Portal. At its inception, the institution was known as the Académie royale de médecine (or ''Royal Academy of Medicine''). This academy was endowed with the legal status of two institutions which preceded it—the Académie royale de chirurgie (or ''Royal Academy of Surgery''), which was created in 1731 and of the Société royale de médecine (or ''Royal Society of Medicine''), which was created in 1776. Background Academy members initially convened at the ''Paris Faculty of Medicine (or Faculté de Médecine de Paris)''. Four years later, the academy acquired its own headquarters, in the form of a mansion in the rue de Poitiers, where it was located until 1850. The office was then relocated to a vaulted hall of the Hospital of Charity on rue Saint Pierre. Their current f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzoic Acid
Benzoic acid is a white (or colorless) solid organic compound with the formula , whose structure consists of a benzene ring () with a carboxyl () substituent. It is the simplest aromatic carboxylic acid. The name is derived from gum benzoin, which was for a long time its only source. Benzoic acid occurs naturally in many plants and serves as an intermediate in the biosynthesis of many secondary metabolites. Salts of benzoic acid are used as food preservatives. Benzoic acid is an important precursor for the industrial synthesis of many other organic substances. The salts and esters of benzoic acid are known as benzoates . History Benzoic acid was discovered in the sixteenth century. The dry distillation of gum benzoin was first described by Nostradamus (1556), and then by Alexius Pedemontanus (1560) and Blaise de Vigenère (1596). Justus von Liebig and Friedrich Wöhler determined the composition of benzoic acid. These latter also investigated how hippuric acid is related ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tonka Beans
''Dipteryx odorata'' (commonly known as "cumaru", "kumaru", or "Brazilian teak") is a species of flowering tree in the pea family, Fabaceae. The tree is native to Central America and northern South America and is semi-deciduous. Its seeds are known as tonka beans (sometimes tonkin beans or tonquin beans). They are black and wrinkled and have a smooth, brown interior. They have a strong fragrance similar to sweet woodruff due to their high content of coumarin. The word ''tonka'' is taken from the Galibi (Carib) tongue spoken by natives of French Guiana; it also appears in Tupi, another language of the same region, as the name of the tree. The old genus name, ''Coumarouna'', was formed from another Tupi name for tree, ''kumarú''. Many anticoagulant prescription drugs, such as warfarin, are based on 4-hydroxycoumarin, a chemical derivative of coumarin initially isolated from this bean. Coumarin, however, does not have anticoagulant properties. Biology of the tree The tree grow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coumarouna
''Dipteryx'' is a genus containing a number of species of large trees and possibly shrubs. It belongs to the "papilionoid" subfamily – Faboideae – of the family Fabaceae. This genus is native to South and Central America and the Caribbean. Formerly, the related genus ''Taralea'' was included in ''Dipteryx''. Description The largest members of ''Dipteryx'' are canopy-emergent trees of tropical rainforests. The tonka bean (''D. odorata'') is grown for its fragrant seeds. ''Baru'' (''D. alata'') is the only species which found in drier, seasonal areas, growing in the cerrado of Brazil; its fruit and seeds are used as food and fodder. Several species are used for timber, of which almendro (''D. oleifera'') wood is considered desirable, especially locally. ''Dipteryx'' can be distinguished from other members of the Dipterygeae by its compound leaves with asymmetric leaflets caused due to an eccentric primary vein, a drupaceous fruit, seeds with a leathery skin, a hilum ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Old Tupi
Old Tupi, Ancient Tupi or Classical Tupi (also spelled as Tupí) is an extinct Tupian language which was spoken by the aboriginal Tupi people of Brazil, mostly those who inhabited coastal regions in South and Southeast Brazil. It belongs to the Tupi–Guarani language family, and has a written history spanning the 16th, 17th, and early 18th centuries. In the early colonial period, Tupi was used as a ''lingua franca'' throughout Brazil by Europeans and aboriginal Americans, and had literary usage, but it was later suppressed almost to extinction. Today, only one modern descendant is living, the Nheengatu language. The names Old Tupi or classical Tupi are used for the language in English and by modern scholars (it is referred to as in Portuguese), but native speakers called it variously "the good language", "common language", "human language", in Old Tupi, or, in Portuguese, "general language", "Amazonian general language", "Brazilian language". History Old Tupi was firs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
French Guiana
French Guiana ( or ; french: link=no, Guyane ; gcr, label=French Guianese Creole, Lagwiyann ) is an overseas departments and regions of France, overseas department/region and single territorial collectivity of France on the northern Atlantic Ocean, Atlantic coast of South America in the Guianas. It borders Brazil to the east and south and Suriname to the west. With a land area of , French Guiana is the second-largest Regions of France, region of France (more than one-seventh the size of Metropolitan France) and the largest Special member state territories and the European Union, outermost region within the European Union. It has a very low population density, with only . (Its population is less than that of Metropolitan France.) Half of its 294,436 inhabitants in 2022 lived in the metropolitan area of Cayenne, its Prefectures in France, capital. 98.9% of the land territory of French Guiana is covered by forests, a large part of which is Old-growth forest, primeval Tropical r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Galibi
The Kalina, also known as the Caribs or mainland Caribs and by several other names, are an indigenous people native to the northern coastal areas of South America. Today, the Kalina live largely in villages on the rivers and coasts of Venezuela, Guyana, Suriname, French Guiana, and Brazil. They speak a Cariban language known as Carib. They may be related to the Island Caribs of the Caribbean, though their languages are unrelated. Name The exonym ''Caribe'' was first recorded by Christopher Columbus. One hypothesis for the origin of ''Carib'' is that it means "brave warrior". Its variants, including the English ''Carib'', were then adopted by other European languages. Early Spanish explorers and administrators used the terms ''Arawak'' and ''Caribs'' to distinguish the peoples of the Caribbean, with ''Carib'' reserved for indigenous groups that they considered hostile and ''Arawak'' for groups that they considered friendly. The Kalina call themselves ''Kalina'' or ''Karìna'' , ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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