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Corwin Hansch
Corwin Herman Hansch (October 6, 1918 – May 8, 2011) was a Professor of Chemistry at Pomona College in California. He became known as the 'father of computer-assisted molecule design.' Education and Career Hansch was born on October 6, 1918 in Kenmare, North Dakota. He earned a BS from the University of Illinois in 1940 and a PhD from New York University in 1944. He briefly worked as a postdoc at the University of Illinois Chicago. Hansch worked on the Manhattan Project at the University of Chicago and as a group leader at DuPont Nemours in Richland, Washington. In February 1946 he received an academic position at Pomona College, where he taught until 1988. Hansch completed sabbaticals at ETH Zurich with Vladimir Prelog and at University of Munich with Rolf Huisgen. Hansch taught Organic Chemistry for many years at Pomona College, and was known for giving complex lectures without using notes. His course in Physical Bio-Organic Medicinal Chemistry was ground-breaking at an und ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kenmare, North Dakota
Kenmare is a city in Ward County, North Dakota, United States. The population was 961 at the 2020 census. Kenmare is part of the Minot Micropolitan Statistical Area. History Kenmare was platted in 1897. The city most likely was named after Kenmare, in Ireland. Geography Kenmare is located at (48.675015, −102.078709). According to the United States Census Bureau, the city has a total area of , all land. Demographics 2010 census As of the census of 2010, there were 1,096 people, 480 households, and 281 families living in the city. The population density was . There were 558 housing units at an average density of . The racial makeup of the city was 95.9% White, 0.2% African American, 0.6% Native American, 0.7% Asian, 1.2% from other races, and 1.4% from two or more races. Hispanic or Latino of any race were 2.6% of the population. There were 480 households, of which 25.0% had children under the age of 18 living with them, 48.8% were married couples living together, 6 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DuPont
DuPont de Nemours, Inc., commonly shortened to DuPont, is an American multinational chemical company first formed in 1802 by French-American chemist and industrialist Éleuthère Irénée du Pont de Nemours. The company played a major role in the development of Delaware and first arose as a major supplier of gunpowder. DuPont developed many polymers such as Vespel, neoprene, nylon, Corian, Teflon, Mylar, Kapton, Kevlar, Zemdrain, M5 fiber, Nomex, Tyvek, Sorona, Corfam and Lycra in the 20th century, and its scientists developed many chemicals, most notably Freon (chlorofluorocarbons), for the refrigerant industry. It also developed synthetic pigments and paints including ChromaFlair. In 2015, DuPont and the Dow Chemical Company agreed to a reorganization plan in which the two companies would merge and split into three. As a merged entity, DuPont simultaneously acquired Dow and renamed itself to DowDuPont on August 31, 2017, and after 18 months spin off the merged entity' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2011 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day The following pages, corresponding to the Gregorian calendar, list the historical events, births, deaths, and holidays and observances of the specified day of the year: Footnotes See also * Leap year * List of calendars * List of non-standard ... * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan Project People
Manhattan (), known regionally as the City, is the most densely populated and geographically smallest of the five boroughs of New York City. The borough is also coextensive with New York County, one of the original counties of the U.S. state of New York. Located near the southern tip of New York State, Manhattan is based in the Eastern Time Zone and constitutes both the geographical and demographic center of the Northeast megalopolis and the urban core of the New York metropolitan area, the largest metropolitan area in the world by urban landmass. Over 58 million people live within 250 miles of Manhattan, which serves as New York City’s economic and administrative center, cultural identifier, and the city’s historical birthplace. Manhattan has been described as the cultural, financial, media, and entertainment capital of the world, is considered a safe haven for global real estate investors, and hosts the United Nations headquarters. New York City is the headquarters of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Pharmacologists
American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, people who self-identify their ancestry as "American" ** American English, the set of varieties of the English language native to the United States ** Native Americans in the United States, indigenous peoples of the United States * American, something of, from, or related to the Americas, also known as "America" ** Indigenous peoples of the Americas * American (word), for analysis and history of the meanings in various contexts Organizations * American Airlines, U.S.-based airline headquartered in Fort Worth, Texas * American Athletic Conference, an American college athletic conference * American Recordings (record label), a record label previously known as Def American * American University, in Washington, D.C. Sports teams Soccer * B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Craig Plot
The Craig plot, named after Paul N. Craig, is a plot of two substituent parameters (e.g. Hansch-Fujita π constant and sigma constant) used in rational drug design. Two most used forms of a Craig plot are * plotting the sigma constants of the Hammett equation versus hydrophobicity * plotting the steric terms of the Taft equation against hydrophobicity See also * Quantitative structure-activity relationship * pKa PKA may refer to: * Professionally known as: ** Pen name ** Stage persona * p''K''a, the symbol for the acid dissociation constant at logarithmic scale * Protein kinase A, a class of cAMP-dependent enzymes * Pi Kappa Alpha, the North-American so ... References Further reading * Medicinal chemistry {{medicinal-chem-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hammett Equation
The Hammett equation in organic chemistry describes a linear free-energy relationship relating reaction rates and equilibrium constants for many reactions involving benzoic acid derivatives with meta- and para-substituents to each other with just two parameters: a substituent constant and a reaction constant. This equation was developed and published by Louis Plack Hammett in 1937 as a follow-up to qualitative observations in a 1935 publication. The basic idea is that for any two reactions with two aromatic reactants only differing in the type of substituent, the change in free energy of activation is proportional to the change in Gibbs free energy.''Advanced Organic Chemistry Part A'' Second Edition F.A. Carey, R.J. Sundberg Plenum Press This notion does not follow from elemental thermochemistry or chemical kinetics and was introduced by Hammett intuitively. The basic equation is: :\log \frac = \sigma\rho relating the equilibrium constant, ''K'', for a given equilibrium re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nobel Prize In Chemistry
) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "MDCCCXXXIII" above, followed by (smaller) "OB•" then "MDCCCXCVI" below. , awarded_for = Outstanding contributions in chemistry , presenter = Royal Swedish Academy of Sciences , location = Stockholm, Sweden , reward = 9 million SEK (2017) , year = 1901 , holder = Carolyn R. Bertozzi, Morten P. Meldal and Karl Barry Sharpless (2022) , most_awards = Frederick Sanger and Karl Barry Sharpless (2) , website nobelprize.org, previous = 2021 , year2=2022, main=2022, next=2023 The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cynthia R
Cynthia is a feminine given name of Greek origin: , , "from Mount Cynthus" on Delos island. The name has been in use in the Anglosphere since the 1600s. There are various spellings for this name, and it can be abbreviated to Cindy, Cyndi, Cyndy, or occasionally to Thea or Thia. Cynthia was originally an epithet of the Greek goddess Artemis, who according to legend was born on Mount Cynthus. Selene, the Greek personification of the moon, and the Roman Diana were also sometimes called "Cynthia". Usage It has ranked among the 1,000 most used names for girls in the United States since 1880 and among the top 100 names between 1945 and 1993. It peaked in usage between 1956 and 1963, when it was among the 10 most popular names for American girls. It has since declined in use in the United States and ranked in 806th position on the popularity chart there in 2021. It was also among the top 100 names in use for girls in Canada between 1949 and 1978, among the top 100 names in use for g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Activity
In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter. When a drug is a complex chemical mixture, this activity is exerted by the substance's active ingredient or pharmacophore but can be modified by the other constituents. Among the various properties of chemical compounds, pharmacological/biological activity plays a crucial role since it suggests uses of the compounds in the medical applications. However, chemical compounds may show some adverse and toxic effects which may prevent their use in medical practice. Activity is generally dosage-dependent. Further, it is common to have effects ranging from beneficial to adverse for one substance when going from low to high doses. Activity depends critically on fulfillment of the ADME criteria. To be an effective drug, a compound not only must be active against a target, but also possess the appropriate ADME (Absorption, Distribution, Metabolism, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rolf Huisgen
Rolf Huisgen (; 13 June 1920 – 26 March 2020) was a German chemist. His importance in synthetic organic chemistry extends to the enormous influence he had in post-war chemistry departments in Germany and Austria, due to a large number of his Habilitation, habilitants becoming professors. His major achievement was the development of the 1,3-dipolar cycloaddition reaction, also called the Azide-alkyne Huisgen cycloaddition, Huisgen cycloaddition. Life Huisgen was born in Gerolstein in Rhineland-Palatinate and studied in Munich under the supervision of Heinrich Otto Wieland. He completed his Ph.D. in 1943 with a thesis about a strychnine alkaloid. He completed his habilitation in 1947, and was appointed professor at the University of Tübingen in 1949. He returned to the University of Munich in 1952, succeeding Wieland, and he remained dedicated to research long after attaining emeritus status there in 1988. One of his major achievements was the development of the 1,3-dipolar c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Munich
The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's List of universities in Germany, sixth-oldest university in continuous operation. Originally University of Ingolstadt, established in Ingolstadt in 1472 by Louis IX, Duke of Bavaria, Duke Ludwig IX of Bavaria-Landshut, the university was moved in 1800 to Landshut by Maximilian I Joseph of Bavaria, King Maximilian I of Bavaria when the city was threatened by the French, before being relocated to its present-day location in Munich in 1826 by Ludwig I of Bavaria, King Ludwig I of Bavaria. In 1802, the university was officially named Ludwig-Maximilians-Universität by King Maximilian I of Bavaria in honor of himself and Ludwig IX. LMU is currently the second-largest university in Germany in terms of student population; in the 2018/19 winter semester, the university had a total of 51,606 m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
