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Conversion Of CBD To THC
Conversion (chemistry), Conversion of cannabidiol (CBD) to tetrahydrocannabinol (THC) can occur through a ring-closing reaction. This cyclization can be acid-catalyzed or brought about by pyrolysis, heating. Known methods Comparison of phytocannabinoids, Phytocannabinoids exist like precursors to their pharmacologically active counterparts. At least three independent methods have successfully converted CBD to THC. * Despite the CBD and THC having the same molecular weight, multiple analytical methods are able to differentiate them. * "on the recovery of both THC (86.7−90.0%) and CBD (92.3−95.6%). The slightly lower recovery of THC can be explained by the fact that THC is less polar than CBD and more likely to remain in the nonpolar sunflower oil." By heat CBD heated to 175, or 250–300 °C may partially be converted into THC. Even at room temperature, trace amounts of THC can be formed as a contaminant in CBD stored for long periods in the presence of moisture and carbo ...
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Conversion (chemistry)
Conversion and its related terms yield and selectivity are important terms in chemical reaction engineering. They are described as ratios of how much of a reactant has reacted (''X'' — conversion, normally between zero and one), how much of a desired product was formed (''Y'' — yield, normally also between zero and one) and how much desired product was formed in ratio to the undesired product(s) (''S'' — selectivity). There are conflicting definitions in the literature for selectivity and yield, so each author's intended definition should be verified. Conversion can be defined for (semi-)batch and continuous reactors and as instantaneous and overall conversion. Assumptions The following assumptions are made: * The following chemical reaction takes place: : \sum_^n \nu_i A_i = \sum_^m \mu_j B_j, where \nu_ and \mu_ are the stoichiometric coefficients. For multiple parallel reactions, the definitions can also be applied, either per reaction or using the limiting react ...
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Zeolites
Zeolites are a group of several Microporous material, microporous, crystalline aluminosilicate minerals commonly used as commercial adsorption, adsorbents and Catalysis, catalysts. They mainly consist of silicon, aluminium, oxygen, and have the general formula ・y where is either a metal ion or H+. The term was originally coined in 1756 by Sweden, Swedish mineralogy, mineralogist Axel Fredrik Cronstedt, who observed that rapidly heating a material, believed to have been stilbite, produced large amounts of steam from water that had been Adsorption, adsorbed by the material. Based on this, he called the material ''zeolite'', from the Greek language, Greek , meaning "to boil" and , meaning "stone". Zeolites occur naturally, but are also produced industrially on a large scale. , 253 unique zeolite frameworks have been identified, and over 40 naturally occurring zeolite frameworks are known. Every new zeolite structure that is obtained is examined by the International Zeolite Associa ...
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Metabolism
Metabolism (, from ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their Structures#Biological, structures, and respond to their environments. The word ''metabolism'' can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. Metabolic reactions may be categorized as ''catabolic''—the ''breaking down'' of compounds (for example, of glucose to pyruvate by c ...
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Oral Administration
Oral administration is a route of administration whereby a substance is taken through the Human mouth, mouth, swallowed, and then processed via the digestive system. This is a common route of administration for many medications. Oral administration can be easier and less painful than other routes of administration, such as Injection (medicine), injection. However, the onset of action is relatively low, and the effectiveness is reduced if it is not absorbed properly in the digestive system, or if it is broken down by digestive enzymes before it can reach the bloodstream. Some medications may cause gastrointestinal side effects, such as nausea or vomiting, when taken orally. Oral administration can also only be applied to conscious patients, and patients able to swallow. Terminology ''Per os'' (; ''P.O.'') is an adverbial phrase meaning literally from Latin "through the mouth" or "by mouth". The expression is used in medicine to describe a treatment that is taken orally (but not ...
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Chromatography
In chemical analysis, chromatography is a laboratory technique for the Separation process, separation of a mixture into its components. The mixture is dissolved in a fluid solvent (gas or liquid) called the ''mobile phase'', which carries it through a system (a column, a capillary tube, a plate, or a sheet) on which a material called the ''stationary phase'' is fixed. Because the different constituents of the mixture tend to have different affinities for the stationary phase and are retained for different lengths of time depending on their interactions with its surface sites, the constituents travel at different apparent velocities in the mobile fluid, causing them to separate. The separation is based on the differential partitioning between the mobile and the stationary phases. Subtle differences in a compound's partition coefficient result in differential retention on the stationary phase and thus affect the separation. Chromatography may be ''preparative'' or ''analytical' ...
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Lucas' Reagent
"Lucas' reagent" is a solution of anhydrous zinc chloride in concentrated hydrochloric acid. This solution is used to classify alcohols of low molecular weight. The reaction is a substitution in which the chloride replaces a hydroxyl group. A positive test is indicated by a change from clear and colourless to turbid, signalling formation of a chloroalkane. Also, the best results for this test are observed in tertiary alcohols, as they form the respective alkyl halides fastest due to higher stability of the intermediate tertiary carbocation. The test was reported in 1930 and became a standard method in qualitative organic chemistry. The test has since become somewhat obsolete with the availability of various spectroscopic and chromatographic methods of analysis. It was named after Howard Lucas (1885–1963). Lucas test The Lucas test in alcohols is a test to differentiate between primary, secondary, and tertiary alcohols. It is based on the difference in reactivity of the th ...
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Dehydrohalogenation
In chemistry, dehydrohalogenation is an elimination reaction which removes a hydrogen halide from a substrate (chemistry), substrate. The reaction is usually associated with the synthesis of alkenes, but it has wider applications. Dehydrohalogenation from alkyl halides Traditionally, alkyl halides are substrates for dehydrohalogenations. The alkyl halide must be able to form an alkene, thus halides having no C–H bond on an adjacent carbon are not suitable substrates. Aryl halides are also unsuitable. Upon treatment with strong base, chlorobenzene dehydrohalogenates to give phenol#Hydrolysis of chlorobenzene, phenol via a benzyne intermediate. Base-promoted reactions to alkenes When treated with a strong base many alkyl chlorides convert to corresponding alkene. It is also called a β-elimination reaction and is a type of elimination reaction. Some prototypes are shown below: :\begin \ce\ &\ce \\ \ce\ &\ce \\ \ce\ &\ce \end Here ethyl chloride reacts with potassium hydroxide, ty ...
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Hydrogen Chloride
The Chemical compound, compound hydrogen chloride has the chemical formula and as such is a hydrogen halide. At room temperature, it is a colorless gas, which forms white fumes of hydrochloric acid upon contact with atmospheric water vapor. Hydrogen chloride gas and hydrochloric acid are important in technology and industry. Hydrochloric acid, the aqueous solution of hydrogen chloride, is also commonly given the formula HCl. Reactions Hydrogen chloride is a diatomic molecule, consisting of a hydrogen atom H and a chlorine atom Cl connected by a Polar-covalent bond, polar covalent bond. The chlorine atom is much more Electronegativity, electronegative than the hydrogen atom, which makes this bond polar. Consequently, the molecule has a large Molecular dipole moment, dipole moment with a negative partial charge (δ−) at the chlorine atom and a positive partial charge (δ+) at the hydrogen atom. In part because of its high polarity, HCl is very soluble in water (and in other ...
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Ferrierite
The ferrierite group of zeolite minerals (the FER structure) consists of four very similar species: ferrierite-magnesium, Mg, ferrierite-sodium, Na, ferrierite-ammonium, NH4 and ferrierite-potassium, K, based on the dominant cation in the A location. ferrierite-Mg and ferrierite-K are orthorhombic minerals and ferrierite-Na is monoclinic with highly variable cationic composition . Calcium and other ions are often also present. They are found in vitreous to pearly, often radiating, spherical aggregates of thin blade-shaped transparent to translucent crystals. Ferrierite typically occurs as an alteration mineral in basaltic rocks and in tuffaceous sediments. In North America, it is found at Kamloops Lake, Kamloops Lake, BC, Canada (the original Type locality (geology), type locality) and Leavitt, California, Leavitt Lake, California. Ferrierite was named for Canadian geologist and mining engineer Walter Frederick Ferrier (1865–1950). Synthetic ferrierite Synthetic ferrierites hav ...
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Phillipsite
Phillipsite is a mineral series of the zeolite group; a hydrated potassium, calcium and aluminium silicate, approximating to . The members of the series are phillipsite-K, phillipsite-Na and phillipsite-Ca. The crystals are monoclinic, but only complex cruciform twins are known, these being exactly like twins of harmotome which also forms a series with phillipsite-Ca. Crystals of phillipsite are, however, usually smaller and more transparent and glassy than those of harmotome. Spherical groups with a radially fibrous structure and bristled with crystals on the surface are not uncommon. The Mohs hardness is 4.5, and the specific gravity is 2.2. The species was established by Armand Lévy in 1825 and named after William Phillips. French authors use the name Christianite (after Christian VIII of Denmark), given by A. Des Cloizeaux in 1847. Phillipsite is a mineral of secondary origin, and occurs with other zeolites in the amygdaloidal cavities of mafic volcanic rocks: for exampl ...
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Mordenite
Mordenite is a zeolite mineral with the chemical formula . and it is one of the six most abundant zeolites and is used commercially. It was first described in 1864 by Henry How. He named it after the small community of Morden, Nova Scotia, Canada, along the Bay of Fundy, where it was first found. Mordenite is orthorhombic (a,b,c unequal & all angles 90 degree). It crystallizes in the form of fibrous aggregates, masses, and vertically striated prismatic crystals. It may be colorless, white, or faintly yellow or pink. It has Mohs hardness of 5 and a density of 2.1 g/cm3. When it forms well developed crystals they are hairlike; very long, thin, and delicate. Mordenite’s molecular structure is a framework containing chains of five-membered rings of linked silicate and aluminate tetrahedra (four oxygen atoms arranged at the points of a triangular pyramid about a central silicon or aluminium atom). Its high ratio of silicon to aluminum atoms makes it more resistant to attack b ...
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Erionite
Erionite is a naturally occurring fibrous mineral that belongs to a group of minerals called zeolites. It usually is found in volcanic ash that has been altered by weathering and ground water. Erionite forms brittle, wool-like fibrous masses in the hollows of rock formations and has an internal molecular structure similar to chabazite. This mineral is likely as toxic as asbestos; however, erionite is not currently regulated by the U.S. Environmental Protection Agency and there are no occupational exposure limits for erionite fibers. Erionite was first described by A.S. Eakle in 1898, as white woolly fibrous masses in cavities in rhyolite lava near Durkee, Oregon. It was originally thought to be another relatively rare zeolite named offretite, which is very similar to erionite in appearance and chemical composition. Properties The chemical composition of erionite is approximately represented by the formula . It can be differentiated into Erionite-Na, Erionite-K, and Erionite ...
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