Congenital Sensorineural Deafness In Cats
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Congenital Sensorineural Deafness In Cats
Congenital sensorineural deafness occurs commonly in domestic cats with a white coat. It is a congenital deafness caused by a degeneration of the inner ear. Deafness is far more common in white cats than in those with other coat colours. According to the ASPCA Complete Guide to Cats, "17 to 20 percent of white cats with nonblue eyes are deaf; 40 percent of "odd-eyed" white cats with one blue eye are deaf; and 65 to 85 percent of blue-eyed white cats are deaf." Charles Darwin mentions this phenomenon in his book, ''On the Origin of Species'', to explain correlated variation. Domesticated cats with blue eyes and white coats are often completely deaf. Deafness can occur in white cats with yellow, green or blue irises, although it is mostly likely in white cats with blue irises. In white cats with mixed-coloured eyes (odd-eyed cats), it has been found that deafness is more likely to affect the ear on the blue-eyed side. White cats can have blue, gold, green or copper coloured odd ey ...
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A Completely Deaf, Pure White Blue-eyed Cat
A, or a, is the first Letter (alphabet), letter and the first vowel of the Latin alphabet, Latin alphabet, used in the English alphabet, modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is English alphabet#Letter names, ''a'' (pronounced ), plural English alphabet#Letter names, ''aes''. It is similar in shape to the Greek alphabet#History, Ancient Greek letter alpha, from which it derives. The Letter case, uppercase version consists of the two slanting sides of a triangle, crossed in the middle by a horizontal bar. The lowercase version can be written in two forms: the double-storey a and single-storey ɑ. The latter is commonly used in handwriting and fonts based on it, especially fonts intended to be read by children, and is also found in italic type. In English grammar, "English articles, a", and its variant "English articles#Indefinite article, an", are Article (grammar)#Indefinite article, indefinite arti ...
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Minks
Mink are dark-colored, semiaquatic, carnivorous mammals of the genera ''Neogale'' and '' Mustela'' and part of the family Mustelidae, which also includes weasels, otters, and ferrets. There are two extant species referred to as "mink": the American mink and the European mink. The extinct sea mink was related to the American mink but was much larger. The American mink's fur has been highly prized for use in clothing. Their treatment on fur farms has been a focus of animal rights and animal welfare activism. American mink have established populations in Europe (including Great Britain and Denmark) and South America. Some people believe this happened after the animals were released from mink farms by animal rights activists, or otherwise escaped from captivity. In the UK, under the Wildlife and Countryside Act 1981, it is illegal to release mink into the wild. In some countries, any live mink caught in traps must be humanely killed. American mink are believed by some to have c ...
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Cat Diseases
The cat (''Felis catus'') is a domestic species of small carnivorous mammal. It is the only domesticated species in the family Felidae and is commonly referred to as the domestic cat or house cat to distinguish it from the wild members of the family. Cats are commonly kept as house pets but can also be farm cats or feral cats; the feral cat ranges freely and avoids human contact. Domestic cats are valued by humans for companionship and their ability to kill rodents. About 60 cat breeds are recognized by various cat registries. The cat is similar in anatomy to the other felid species: they have a strong flexible body, quick reflexes, sharp teeth, and retractable claws adapted to killing small prey. Their night vision and sense of smell are well developed. Cat communication includes vocalizations like meowing, purring, trilling, hissing, growling, and grunting as well as cat-specific body language. Although the cat is a social species, they are a solitary hunter. As a pre ...
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Waardenburg Syndrome
Waardenburg syndrome is a group of rare genetic conditions characterised by at least some degree of congenital hearing loss and pigmentation deficiencies, which can include bright blue eyes (or Heterochromia iridum, one blue eye and one brown eye), a white forelock or patches of light skin. These basic features constitute type 2 of the condition; in type 1, there is also a wider gap between the inner corners of the eyes called telecanthus, telecanthus, or dystopia canthorum. In type 3, which is rare, the arms and hands are also malformed, with Camptodactyly, permanent finger contractures or fused fingers, while in type 4, the person also has Hirschsprung's disease. There also exist at least two types (2E and PCWH) that can result in central nervous system (CNS) symptoms such as developmental delay and muscle tone abnormalities. The syndrome is caused by mutations in any of several genes that affect the Cell division, division and Cell migration, migration of neural crest cells d ...
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Van Cat
The Van cat ( tr, Van kedisi; ; Eastern ; ku, pisîka Wanê, script=Latn, italic=yes) is a distinctive landrace of the domestic cat found in the Lake Van area of the Armenian Highlands in Turkey. Van cats are relatively large, have a chalky white coat, sometimes with ruddy coloration on the head and hindquarters, and have blue or amber eyes or have heterochromia (one eye of each colour). Like many sources, this one conflates the Turkish Van standarised breed, which is actually British, with the local Van cat landrace of Turkey, and so must be interpreted with caution. /www.microsofttranslator.com/bv.aspx?from=tr&to=en&a=http://www.vankedisi.net/ Machine translation into English The variety has been referred to as "the swimming cat", and has been observed to swim in Lake Van. The naturally occurring Van cat type is popularly believed to be the basis of the Turkish Van breed, as standardised and recognised by many cat fancier organizations; it has been internationally ...
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Pleiotropy
Pleiotropy (from Greek , 'more', and , 'way') occurs when one gene influences two or more seemingly unrelated phenotypic traits. Such a gene that exhibits multiple phenotypic expression is called a pleiotropic gene. Mutation in a pleiotropic gene may have an effect on several traits simultaneously, due to the gene coding for a product used by a myriad of cells or different targets that have the same signaling function. Pleiotropy can arise from several distinct but potentially overlapping mechanisms, such as gene pleiotropy, developmental pleiotropy, and selectional pleiotropy. Gene pleiotropy occurs when a gene product interacts with multiple other proteins or catalyzes multiple reactions. Developmental pleiotropy occurs when mutations have multiple effects on the resulting phenotype. Selectional pleiotropy occurs when the resulting phenotype has many effects on fitness (depending on factors such as age and gender). An example of pleiotropy is phenylketonuria, an inherited d ...
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Merle (dog Coat)
Merle is a genetic pattern that can be in a dog's coat. Merle comes in different colors and patterns and can affect all coat colors. The merle gene creates mottled patches of color in a solid or piebald coat, blue or odd-colored eyes, and can affect skin pigment as well. There are two general types of colored patches that will appear in a merle coat: liver (red merle) and black (blue merle). Some breeds that can be affected by this genetic trait are Carea Leonés, Australian Shepherds and Catahoula Leopard Dogs. This genetic trait should be taken seriously when breeding merles. Health issues are more typical and more severe when two merles are bred together, so it is recommended that a merle be bred with a non-merle dog of any other color. Description Merle can affect all coat colors. The merle forms of brown and black are usually called "red" (though this is not correct; red and brown are genetically different) and "blue" as patches of blue are formed throughout the coat. ...
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Cat Coat Genetics
Cat coat genetics determine the coloration, pattern, length, and texture of feline fur. Understanding how can be challenging because many genes are involved. The variations among cat coats are physical properties and should not be confused with cat breeds. A cat may display the coat of a certain breed without actually being that breed. For example, a Siberian cat, Siberian could wear point coloration, the stereotypical coat of a Siamese cat, Siamese. Solid colors Eumelanin The browning gene ''B/b/bl'' codes for TYRP1 (), an enzyme involved in the metabolic pathway for eumelanin pigment production. Its dominant form, ''B'', will produce black eumelanin. It has two recessive variants, ''b'' (chocolate) and ''bl'' (cinnamon), with ''bl'' being recessive to both ''B'' and ''b''. Chocolate is a rich dark brown color, and is referred to as chestnut in some breeds. Cinnamon is a light reddish brown, but is sometimes not reddish at all. Sex-linked orange/red The sex-linked ' ...
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A Dangerous Path
''A Dangerous Path'' is a fantasy novel, the fifth book in the ''Warriors'' series, written under the pseudonym of Erin Hunter. This individual book was written by Cherith Baldry. The story centers around Fireheart, deputy of ThunderClan, as he attempts to keep his Clan safe with the help of his ailing leader, while fighting off outside threats such as dogs and enemy Clans. The book was first published in the US as a hardcover on 1 June 2004. It has since been published as a paperback and as an e-book, and been published in other countries. ''A Dangerous Path'' has also been published in foreign languages, including French and Chinese. The book received positive reviews from reviewers such as ''Booklist'' and '' Horn Book Review'', who praised the tensions and fast pace. Synopsis Setting The story takes place in a fictional forest populated by four groups of feral cats, ThunderClan, RiverClan, WindClan and ShadowClan. Each Clan has their own territory in which they live an ...
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Cat Coat Genetics
Cat coat genetics determine the coloration, pattern, length, and texture of feline fur. Understanding how can be challenging because many genes are involved. The variations among cat coats are physical properties and should not be confused with cat breeds. A cat may display the coat of a certain breed without actually being that breed. For example, a Siberian cat, Siberian could wear point coloration, the stereotypical coat of a Siamese cat, Siamese. Solid colors Eumelanin The browning gene ''B/b/bl'' codes for TYRP1 (), an enzyme involved in the metabolic pathway for eumelanin pigment production. Its dominant form, ''B'', will produce black eumelanin. It has two recessive variants, ''b'' (chocolate) and ''bl'' (cinnamon), with ''bl'' being recessive to both ''B'' and ''b''. Chocolate is a rich dark brown color, and is referred to as chestnut in some breeds. Cinnamon is a light reddish brown, but is sometimes not reddish at all. Sex-linked orange/red The sex-linked ' ...
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KIT (gene)
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich in 1987 as the cellular homolog of the feline sarcoma viral oncogene v-kit. Function KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor , also known as "steel factor" or "c-kit ligand". When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. After ac ...
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Allele
An allele (, ; ; modern formation from Greek ἄλλος ''állos'', "other") is a variation of the same sequence of nucleotides at the same place on a long DNA molecule, as described in leading textbooks on genetics and evolution. ::"The chromosomal or genomic location of a gene or any other genetic element is called a locus (plural: loci) and alternative DNA sequences at a locus are called alleles." The simplest alleles are single nucleotide polymorphisms (SNP). but they can also be insertions and deletions of up to several thousand base pairs. Popular definitions of 'allele' typically refer only to different alleles within genes. For example, the ABO blood grouping is controlled by the ABO gene, which has six common alleles (variants). In population genetics, nearly every living human's phenotype for the ABO gene is some combination of just these six alleles. Most alleles observed result in little or no change in the function of the gene product it codes for. However, ...
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