Computational Anatomy Toolbox
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Computational Anatomy Toolbox
CAT (computational anatomy toolbox) is a free and open source software package used for the analysis of structural brain imaging data, in particular magnetic resonance imaging (MRI). Developed by Christian Gaser and Robert Dahnke of the Structural Brain Mapping Group at the University of Jena, CAT is an extension of the SPM software. Functionality CAT provides tools for voxel-based morphometry (VBM), cortical thickness, folding, and gyrification analysis, as well as volume or surface estimates within predefined brain regions of interest. Related software * SPM * FSL (FMRIB Software Library) * AFNI * Freesurfer * Caret Caret () is the name used familiarly for the character provided on most QWERTY keyboards by typing . The symbol has a variety of uses in programming and mathematics. The name "caret" arose from its visual similarity to the original proofre ... References {{reflist Biostatistics Neuroimaging Computing in medical imaging ...
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Matlab
MATLAB (an abbreviation of "MATrix LABoratory") is a proprietary multi-paradigm programming language and numeric computing environment developed by MathWorks. MATLAB allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages. Although MATLAB is intended primarily for numeric computing, an optional toolbox uses the MuPAD symbolic engine allowing access to symbolic computing abilities. An additional package, Simulink, adds graphical multi-domain simulation and model-based design for dynamic and embedded systems. , MATLAB has more than four million users worldwide. They come from various backgrounds of engineering, science, and economics. , more than 5000 global colleges and universities use MATLAB to support instruction and research. History Origins MATLAB was invented by mathematician and computer programmer Cleve Moler. The idea for MATLAB was base ...
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University Of Jena
The University of Jena, officially the Friedrich Schiller University Jena (, abbreviated FSU, shortened form ''Uni Jena''), is a public research university located in Jena, Thuringia, Germany. The university was established in 1558 and is counted among the ten oldest universities in Germany. It is affiliated with six Nobel Prize winners, most recently in 2000 when Jena graduate Herbert Kroemer won the Nobel Prize for physics. It was renamed after the poet Friedrich Schiller who was teaching as professor of philosophy when Jena attracted some of the most influential minds at the turn of the 19th century. With Karl Leonhard Reinhold, Johann Gottlieb Fichte, G. W. F. Hegel, F. W. J. Schelling and Friedrich Schlegel on its teaching staff, the university was at the centre of the emergence of German idealism and early Romanticism. , the university has around 19,000 students enrolled and 375 professors. Its current president, Walter Rosenthal, has held the role since 2014. Hi ...
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Biostatistics
Biostatistics (also known as biometry) is a branch of statistics that applies statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results. History Biostatistics and genetics Biostatistical modeling forms an important part of numerous modern biological theories. Genetics studies, since its beginning, used statistical concepts to understand observed experimental results. Some genetics scientists even contributed with statistical advances with the development of methods and tools. Gregor Mendel started the genetics studies investigating genetics segregation patterns in families of peas and used statistics to explain the collected data. In the early 1900s, after the rediscovery of Mendel's Mendelian inheritance work, there were gaps in understanding between genetics and evolutionary Darwinism. Francis Galton tried to expand Mendel's ...
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Caret (software)
CARET (Computerized Anatomical Reconstruction Toolkit) is a software application for the structural and functional analysis of the cerebral and cerebellar cortex. CARET is developed in the Van Essen Laboratory in the Department of Anatomy and Neurobiology at the Washington University School of Medicine in St. Louis, Missouri. CARET is a free, open-source application distributed in both binary and source formats under the GNU General Public License. CARET runs on FreeBSD, Linux, Mac OS X, and Microsoft Windows. CARET's capabilities * Analysis of group anatomical differences using sulcal depth morphometry. * Display of activation foci. * Generation of flat, inflated, spherical surfaces. * Mapping of fMRI volumes onto surfaces. * Surface reconstruction from anatomical MRI volumes using the SureFit algorithm. * Surface reconstruction from contours. * Surface-based registration. * Visualization of contours, surfaces, and volumes. Related Software SuMS Database and WebCaretprovid ...
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FreeSurfer
FreeSurfer is brain List of neuroimaging software, imaging software originally developed by Bruce Fischl, Anders Dale, Martin Sereno, and Doug Greve. Development and maintenance of FreeSurfer is now the primary responsibility of the Laboratory for Computational Neuroimaging at the Athinoula A. Martinos Center for Biomedical Imaging. FreeSurfer contains a set of programs with a common focus of analyzing magnetic resonance imaging (MRI) scans of brain tissue. It is an important tool in functional brain mapping and contains tools to conduct both volume based and surface based analysis. FreeSurfer includes tools for the reconstruction of topologically correct and geometrically accurate models of both the gray/white and Pia mater, pial surfaces, for measuring cortical thickness, surface area and folding, and for computing inter-subject registration based on the pattern of cortical folds. 57,541 copies of the FreeSurfer software package have been registered for use as of April 2022 and ...
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AFNI
Analysis of Functional NeuroImages (AFNI) is an open-source environment for processing and displaying functional MRI data—a technique for mapping human brain activity. AFNI is an agglomeration of programs that can be used interactively or flexibly assembled for batch processing using shell script. The term ''AFNI'' refers both to the entire suite and to a particular interactive program often used for visualization. AFNI is actively developed by the NIMH Scientific and Statistical Computing Core and its capabilities are continually expanding. AFNI runs under many Unix-like operating systems that provide X11 and Motif libraries, including IRIX, Solaris, Linux, FreeBSD and OS X. Precompiled binaries are available for some platforms. AFNI is available for research use under the GNU General Public License, the included SVM-light component is non-commercial and non-distributable. AFNI now comprises over 300,000 lines of C source code, and a skilled C programmer can add interactiv ...
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FMRIB Software Library
The FMRIB Software Library, abbreviated FSL, is a software library containing image analysis and statistical tools for functional, structural and diffusion MRI brain imaging data. FSL is available as both precompiled binaries and source code for Apple and PC (Linux) computers. It is freely available for non-commercial use. FSL Functionality History and development FSL is written mainly by members of the FMRIB (Functional Magnetic Resonance Imaging of the Brain) Analysis Group, Oxford University, UK. The first release of FSL was in 2000; there has been approximately one major new release each year to date. The FMRIB Analysis Group is primarily funded by the Wellcome Trust and the UK EPSRC and MRC Research Councils. See also * AFNI * FreeSurfer * Computational anatomy toolbox * SPM * Neuroimaging Neuroimaging is the use of quantitative (computational) techniques to study the neuroanatomy, structure and function of the central nervous system, developed as an objective way ...
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Region Of Interest
A region of interest (often abbreviated ROI) is a sample within a data set identified for a particular purpose. The concept of a ROI is commonly used in many application areas. Existing as a vicinity, or within one. For example, in medical imaging, the boundaries of a tumor may be defined on an image or in a volume, for the purpose of measuring its size. The endocardial border may be defined on an image, perhaps during different phases of the cardiac cycle, for example, end-systole and end-diastole, for the purpose of assessing cardiac function. In geographical information systems (GIS), a ROI can be taken literally as a polygonal selection from a 2D map. In computer vision and optical character recognition, the ROI defines the edge detection, borders of an object under consideration. In many applications, symbolic (textual) labels are added to a ROI, to describe its content in a compact manner. Within a ROI may lie individual ''point of interest, points of interest'' (POIs). Exam ...
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Voxel-based Morphometry
Voxel-based morphometry is a computational approach to neuroanatomy that measures differences in local concentrations of brain tissue, through a voxel-wise comparison of multiple brain images. In traditional morphometry, volume of the whole brain or List of regions in the human brain, its subparts is measured by drawing regions of interest (ROIs) on images from brain scanning and calculating the volume enclosed. However, this is time consuming and can only provide measures of rather large areas. Smaller differences in volume may be overlooked. The value of VBM is that it allows for comprehensive measurement of differences, not just in specific structures, but throughout the entire brain. VBM Image registration, registers every brain to a template, which gets rid of most of the large differences in brain anatomy among people. Then the brain images are smoothed so that each voxel represents the average of itself and its neighbors. Finally, the image volume is compared across brains a ...
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Statistical Parametric Mapping
Statistical parametric mapping (SPM) is a statistical technique for examining differences in brain activity recorded during functional neuroimaging experiments. It was created by Karl Friston. It may alternatively refer to software created by the Wellcome Department of Imaging Neuroscience at University College London to carry out such analyses. Approach Unit of measurement Functional neuroimaging is one type of 'brain scanning'. It involves the measurement of brain activity. The measurement technique depends on the imaging technology (e.g., fMRI and PET). The scanner produces a 'map' of the area that is represented as voxels. Each voxel represents the activity of a specific volume in three-dimensional space. The exact size of a voxel varies depending on the technology. fMRI voxels typically represent a volume of 27 mm3 in an equilateral cuboid. Experimental design Researchers examine brain activity linked to a specific mental process or processes. One approach involves as ...
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Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and radio waves to form images of the organs in the body. MRI does not involve X-rays or the use of ionizing radiation, which distinguishes it from computed tomography (CT) and positron emission tomography (PET) scans. MRI is a medical application of nuclear magnetic resonance (NMR) which can also be used for imaging in other NMR applications, such as NMR spectroscopy. MRI is widely used in hospitals and clinics for medical diagnosis, staging and follow-up of disease. Compared to CT, MRI provides better contrast in images of soft tissues, e.g. in the brain or abdomen. However, it may be perceived as less comfortable by patients, due to the usually longer and louder measurements with the subject in a long, confining tube, although ...
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C (programming Language)
C (''pronounced'' '' – like the letter c'') is a general-purpose programming language. It was created in the 1970s by Dennis Ritchie and remains very widely used and influential. By design, C's features cleanly reflect the capabilities of the targeted Central processing unit, CPUs. It has found lasting use in operating systems code (especially in Kernel (operating system), kernels), device drivers, and protocol stacks, but its use in application software has been decreasing. C is commonly used on computer architectures that range from the largest supercomputers to the smallest microcontrollers and embedded systems. A successor to the programming language B (programming language), B, C was originally developed at Bell Labs by Ritchie between 1972 and 1973 to construct utilities running on Unix. It was applied to re-implementing the kernel of the Unix operating system. During the 1980s, C gradually gained popularity. It has become one of the most widely used programming langu ...
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