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Combretum Leprosum
''Combretum leprosum'', the mofumbo in Portuguese and the asucaró in eastern Bolivian Spanish, is a plant species in the genus ''Combretum ''Combretum'', the bushwillows or combretums, make up the type genus of the family Combretaceae. The genus comprises about 272 species of trees and shrubs, most of which are native to tropical and southern Africa, about 5 to Madagascar, but th ...'' found throughout the Amazon Basin. This plant contains combretastatin A-4. In many areas of the eastern Bolivian countryside, people have traditionally maintained specimens of these trees and encouraged their proliferation because they are perceived to be useful providers of shade. References External links leprosum Flora of Brazil Plants described in 1841 {{Myrtales-stub ...
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Carl Friedrich Philipp Von Martius
Carl Friedrich Philipp (Karl Friedrich Philipp) von Martius (17 April 1794 – 13 December 1868) was a German botanist and explorer. Life Martius was born at Erlangen, the son of Prof Ernst Wilhelm Martius, court apothecary. He graduated PhD from Erlangen University in 1814, publishing as his thesis a critical catalogue of plants in the university's botanical garden. After that he continued to devote himself to botanical study, and in 1817 he and Johann Baptist von Spix were sent to Brazil by Maximilian I Joseph, the king of Bavaria. They travelled from Rio de Janeiro through several of the southern and eastern provinces of Brazil and travelled up the Amazon River to Tabatinga, as well as exploring some of its larger tributaries. On his return to Europe in 1820 Martius was appointed as the keeper of the botanic garden at Munich, including the herbarium at the Munich Botanical Collection, and in 1826 as professor of botany in the university there, and he held both offices unti ...
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Combretum
''Combretum'', the bushwillows or combretums, make up the type genus of the family Combretaceae. The genus comprises about 272 species of trees and shrubs, most of which are native to tropical and southern Africa, about 5 to Madagascar, but there are others that are native to tropical Asia, New Guinea and the Bismarck Archipelago, Australia, and tropical America. Though somewhat reminiscent of willows (''Salix'') in their habitus, they are not particularly close relatives of these. Ecology Bushwillow trees often are important plants in their habitat. Savannahs in Africa, in particular those growing on granitic soils, are often dominated by ''Combretum'' and its close relative ''Terminalia''. For example, ''C. apiculatum'' is a notable tree in the Angolan mopane woodlands ecoregion in the Kunene River basin in southern Africa. Other species of this genus are a major component of Southwestern Amazonian moist forests. This genus contains several species that are pollinated by ma ...
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Amazon Basin
The Amazon basin is the part of South America drained by the Amazon River and its tributaries. The Amazon drainage basin covers an area of about , or about 35.5 percent of the South American continent. It is located in the countries of Bolivia, Brazil, Colombia, Ecuador, Guyana, Peru, Suriname, and Venezuela. Most of the basin is covered by the Amazon rainforest, also known as Amazonia. With a area of dense tropical forest, this is the largest rainforest in the world.   Geography The Amazon River begins in the Andes Mountains at the west of the basin with its main tributary the Marañón River and Apurimac River in Peru. The highest point in the watershed of the Amazon is the second biggest peak of Yerupajá at . With a length of about before it drains into the Atlantic Ocean, it is one of the two longest rivers in the world. A team of scientists has claimed that the Amazon is longer than the Nile, but debate about its exact length continues. The Amazon system ...
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Combretastatin A-4
Combretastatin A-4 is a combretastatin and a stilbenoid. It can be isolated from '' Combretum caffrum'', the Eastern Cape South African bushwillow tree or in '' Combretum leprosum'', the mofumbo, a species found in Brazil. Function Tubulin represents a potent target in cancer chemotherapy, given its role in cell division. Combretastatin is a naturally occurring well known tubulin polymerization inhibitor. Combretastatin A-4 comes in two stereoisomers (cis (shown top right), and trans); The cis form binds much better to the 'colchicine' site on tubulin to inhibit polymerization. Derivatives Combretastatin A-4 is the active component of combretastatin A-4 phosphate, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. A large number of synthetic derivatives have been reported, including beta-lactam A beta-lactam (β-lactam) ring is a four-membered lactam. A ''lactam'' is a cyclic amide, and ''beta''-lactams are named so be ...
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Flora Of Brazil
The wildlife of Brazil comprises all naturally occurring animals, plants, and fungi in the South American country. Home to 60% of the Amazon Rainforest, which accounts for approximately one-tenth of all species in the world, Brazil is considered to have the greatest biodiversity of any country on the planet. It has the most known species of plant Plants are predominantly photosynthetic eukaryotes of the kingdom Plantae. Historically, the plant kingdom encompassed all living things that were not animals, and included algae and fungi; however, all current definitions of Plantae exclud ...s (55,000), freshwater fish (3,000), and mammals (over 689). It also ranks third on the list of countries with the most bird species (1,832) and second with the most reptile species (744). The number of fungal species is unknown but is large.Da Silva, M. and D.W. Minter. 1995. ''Fungi from Brazil recorded by Batista and Co-workers''. Myc ...
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