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Cocaine
Cocaine (from , from , ultimately from Quechua: ''kúka'') is a central nervous system (CNS) stimulant. As an extract it is mainly used recreationally and often illegally for its euphoric effects. It is also used in medicine by Indigenous South Americans for various purposes and rarely as a local anaesthetic elsewhere. It is primarily obtained from the leaves of two Coca species native to South America: ''Erythroxylum coca'' and '' E. novogranatense''. After extraction from the plant, and further processing into cocaine hydrochloride (powdered cocaine), the drug is administered by being either snorted, applied topically to the mouth, or dissolved and injected into a vein. It can also then be turned into free base form ( crack cocaine), in which it can be heated until sublimated and then the vapours can be inhaled. Cocaine stimulates the reward pathway in the brain. Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Topical
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. The word ''topical'' derives from Greek τοπικός ''topikos'', "of a place". Justification Topical drug delivery is a route of administering drugs via the skin to provide topical therapeutic effects. As skin is one of the largest and most superficial organs in the human body, pharmacists utilise it to deliver various drugs. This ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coca
Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. The plant is grown as a cash crop in the Argentine Northwest, Bolivia, Alto Rio Negro Territory in Brazil, Colombia, Venezuela, Ecuador, and Peru, even in areas where its cultivation is unlawful. There are some reports that the plant is being cultivated in the south of Mexico, by using seeds imported from South America, as an alternative to smuggling its recreational product cocaine. It also plays a role in many traditional Amazonian and Andean cultures as well as the Sierra Nevada de Santa Marta in northern Colombia. The cocaine alkaloid content of dry ''Erythroxylum coca'' var. ''coca'' leaves was measured ranging from 0.23% to 0.96%. Coca-Cola used coca leaf extract in its products from 1885 until about 1903, when it began using decocainized leaf extract. Extraction of cocaine from coca requires several sol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Route Of Administration
A route of administration in pharmacology and toxicology is the way by which a medication, drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral administration, oral and intravenous therapy, intravenous administration. Routes can also be classified based on where the target of action is. Action may be topical medication, topical (local), enteral administration, enteral (system-wide effect, but delivered through the gastrointestinal tract), or #Parenteral, parenteral (systemic action, but delivered by routes other than the GI tract). Route of administration and dosage form are aspects of drug delivery. Classification Routes of administration are usually classified by application location (or exposition). The route or course the active substance takes from application location to the location where it has its target effect is usually rather ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative name is muriate, derived from hydrochloric acid's ancient name: muriatic acid. Uses Converting amines into their hydrochlorides is a common way to improve their water solubility, which can be desirable for substances used in medications. The European Pharmacopoeia lists more than 200 hydrochlorides as active ingredients in medications. These hydrochlorides, compared to free bases, may more readily dissolve in the gastrointestinal tract and be absorbed into the bloodstream more quickly. Additionally, many hydrochlorides of amines have a longer shelf-life than their respective free bases. Amine hydrochlorides represent latent forms of a more reactive free base. In this regard, formation of an amine hydrochloride confers protection. This eff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythroxylum Novogranatense
''Erythroxylum novogranatense'' is a neotropical species of ''Erythroxylum'' (Erythroxylaceae). Cocaine is produced from the leaves. Name "Novogranatense" is derived from Latin: ''novo'' (new) and ''granatense'' (Granada). It was named by William Turner Thiselton-Dyer, the third director of Royal Botanic Gardens, Kew, because its country of origin was the Spanish colonial Viceroyalty of New Granada—present day Colombia. Subspecies ''Erythroxylum novogranatense'' contains 2 subspecies: *''Erythroxylum novogranatense'' var. ''novogranatense'' (D.Morris) Hieron *''Erythroxylum novogranatense'' var. ''truxillense'' (Rusby) Plowman These two subspecies are phenotypically similar, but morphologically distinguishable. Taxonomy Among the genus ''Erythroxylum'', cocaine-rich leaves are obtained from 4 taxa: *''Erythroxylum coca'' var. ''coca'' *''Erythroxylum coca'' var. '' ipadu'' *''Erythroxylum novogranatense'' var. ''novogranatense'' *''Erythroxylum novogranatense'' var. ''truxi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Erythroxylum Coca
''Erythroxylum coca'' is one of two species of cultivated coca. Description The coca plant resembles a blackthorn bush, and grows to a height of . The branches are straight, and the leaves, which have a green tint, are thin, opaque, oval, and taper at the extremities. A marked characteristic of the leaf is an areolated portion bounded by two longitudinal curved lines, one line on each side of the midrib, and more conspicuous on the underside of the leaf. The flowers are small, and disposed in little clusters on short stalks; the corolla is composed of five yellowish-white petals, the anthers are heart-shaped, and the pistil consists of three carpels united to form a three-chambered ovary. The flowers mature into red berries. Unlike ''Erythroxylum novogranatense'', ''Erythroxylum coca'' requires very acidic soil conditions. Soil acidity and water acidity need to be below pH 5.5, with the optimal value being pH 3.5, similar to that of ''Rhododendron'' potting soils. At pH 6.5 and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coca
Coca is any of the four cultivated plants in the family Erythroxylaceae, native to western South America. Coca is known worldwide for its psychoactive alkaloid, cocaine. The plant is grown as a cash crop in the Argentine Northwest, Bolivia, Alto Rio Negro Territory in Brazil, Colombia, Venezuela, Ecuador, and Peru, even in areas where its cultivation is unlawful. There are some reports that the plant is being cultivated in the south of Mexico, by using seeds imported from South America, as an alternative to smuggling its recreational product cocaine. It also plays a role in many traditional Amazonian and Andean cultures as well as the Sierra Nevada de Santa Marta in northern Colombia. The cocaine alkaloid content of dry ''Erythroxylum coca'' var. ''coca'' leaves was measured ranging from 0.23% to 0.96%. Coca-Cola used coca leaf extract in its products from 1885 until about 1903, when it began using decocainized leaf extract. Extraction of cocaine from coca requires several sol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Local Anaesthetic
A local anesthetic (LA) is a medication that causes absence of pain sensation. In the context of surgery, a local anesthetic creates an absence of pain in a specific location of the body without a loss of consciousness, as opposed to a general anesthetic. When it is used on specific nerve pathways (local anesthetic nerve block), paralysis (loss of muscle power) also can be achieved. Examples Short Duration & Low Potency Procaine Chloroprocaine Medium Duration & Potency Lidocaine Prilocaine High Duration & Potency Tetracaine Bupivacaine Cinchocaine Ropivacaine Clinical LAs belong to one of two classes: aminoamide and aminoester local anesthetics. Synthetic LAs are structurally related to cocaine. They differ from cocaine mainly in that they have a very low abuse potential and do not produce hypertension or (with few exceptions) vasoconstriction. They are used in various techniques of local anesthesia such as: * Topical anesthesia (surface) * Topical administration o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indigenous South Americans
The Indigenous peoples of South America or South American Indigenous peoples, are the pre-Colombian peoples of South America and their descendants. These peoples contrast with South Americans of European ancestry and those of African descent. In Spanish, Indigenous people are often referred to as ''indígenas'' or ''pueblos indígenas'' (lit. Indigenous peoples). They may also be called ''pueblos nativos'' or ''nativos'' (lit. Native peoples). The term ''aborigen'' (lit. aborigine) is used in Argentina and ''pueblos aborígenes'' (lit. aboriginal peoples) is commonly used in Colombia. The English term "Amerindian" (short for "Indians of the Americas") is often used in the Guianas. Latin Americans of mixed European and Indigenous descent are usually referred to as mestizos (Spanish) and mestiços (Portuguese). While those of mixed African and Indigenous ancestry are referred to as zambos. It is believed that the first human populations of South America either arrived from As ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicine
Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others. Medicine has been practiced since prehistoric times, and for most of this time it was an art (an area of skill and knowledge), frequently having connections to the religious and philosophical beliefs of local culture. For example, a medicine man would apply herbs and say prayers for healing, o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Euphoria
Euphoria ( ) is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music and dancing, can induce a state of euphoria. Euphoria is also a symptom of certain neurological or neuropsychiatric disorders, such as mania. Romantic love and components of the human sexual response cycle are also associated with the induction of euphoria. Certain drugs, many of which are addictive, can cause euphoria, which at least partially motivates their recreational use. Hedonic hotspots – i.e., the pleasure centers of the brain – are functionally linked. Activation of one hotspot results in the recruitment of the others. Inhibition of one hotspot results in the blunting of the effects of activating another hotspot. Therefore, the simultaneous activation of every hedonic hotspot within the reward system is believed to be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recreational Drug Use
Recreational drug use indicates the use of one or more psychoactive drugs to induce an altered state of consciousness either for pleasure or for some other casual purpose or pastime by modifying the perceptions and emotions of the user. When a psychoactive drug enters the user's body, it induces an intoxicating effect. Generally, recreational drugs are divided into three categories: depressants (drugs that induce a feeling of relaxation and calmness); stimulants (drugs that induce a sense of energy and alertness); and hallucinogens (drugs that induce perceptual distortions such as hallucination). In popular practice, recreational drug use generally is a tolerated social behaviour, rather than perceived as the medical condition of self-medication. However, heavy use of some drugs is socially stigmatized. Many people also use prescribed and controlled depressants such as opioids, as well as opiates and benzodiazepines. Common recreational drugs include caffeine, commonly foun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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